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Synthesis and Antiproliferative Activity of 2-Oxo-4-Cyano-1,2-Dihydropyridine-3-Carboxamides
2-Oxo-4-cyano-1,2-dihydropyridine-3-carboxamides were synthesized. Their antiproliferative activity was studied. They were shown to inhibit slightly...
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Synthesis and Antiproliferative Activity of 2-oxo-1,2-dihydropyridine-3,4-dicarbonitriles
A series of 2-oxo-1,2-dihydropyridine-3,4-dicarbonitriles were synthesized. Their antiproliferative activity was studied. Substituents in the...
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Design, Synthesis and Biological Evaluation of 7-Azaindole Analogues as Novel Antiproliferative Agent and Tyrosine Protein Kinase SRC Inhibitors
A new series of SRC inhibitors based on 7-azaindole core were designed, synthesized and evaluated for antiproliferative and antioxidant activities....
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One-Pot Multicomponent Synthesis, Antibacterial and Antiproliferative Evaluation of Indole Derivatives
Aseries of indole derivatives 1—3 have been synthesized in moderate to good yields by a one-pot, three-component cyclocondensation reaction of...
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Synthesis, Antiproliferative and Antioxidant Activity of 3-Mercapto-1,2,4-Triazole Derivatives as Combretastatin A-4 Analogues
Two series of 3-mercapto-1,2,4-triazole derivatives containing alkoxy substituents different in size and position were synthesized and their...
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Synthesis, Antiproliferative, and Molecular Docking Studies of 3-Mercapto-1,2,4-Triazole Derivatives as Combretastatin A-4 Analogs
In the present work, a series of 1,2,4-triazole derivatives are designed as combretastatin A-4 analogs with the 4-nitrophenyl group and different...
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Comparative Study on Phytochemical Profiles, Antiproliferative, Antimicrobial and Antioxidant Activities of Adonis Species from Turkey
The present study aimed to determine antiproliferative, antimicrobial, antioxidant activities and also phytochemical composition of different nine...
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Antiproliferative Activity of 3-Cyanocoumarins and 2-Aminochromeno[2,3-b ]Pyridine-3-Carbonitriles, Derivatives of 2-Amino-4H-Chromene-3-Carbonitrile
The antiproliferative activity of the previously synthesized 2-amino-4 H -chromene-3-carbonitrile derivatives 4,7-disubstituted 3-cyanocoumarins and...
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Antiproliferative Activity Missing in 6-Substituted Polycarbonitrile Derivatives of 3-Azabicyclo[3.1.0]Hexane
The antiproliferative activity of 6-substituted polycarbonitrile derivatives of 3-azabicyclo[3.1.0]hexane was studied. It was established that the...
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Antiproliferative Activity of Extracts Containing Flavonoids from In Vitro Callus Cultures of Astragalus onobrychis
Astragalus onobrychis L., Fabaceae, is a perennial herbaceous plant with a strong taproot and reaches a height of 10–60 cm. The stems have a woody...
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Antiproliferative Activity of the Cyclization Products of 1-(2-Oxocyclohexyl)Ethane-1,1,2,2-Tetracarbonitrile and α,β-Unsaturated Aldehydes
The antiproliferative activity of previously obtained 3- R -6-imino-2,7-dioxabicyclo[3.2.1.]octane-4,4,5-tricarbonitriles was tested on 59 cell lines...
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Synthesis, Structure, and Antiproliferative Activities of Complexes of Some Transition Metals with 5,7-Dichloro-8-Hydroxyquinoline-2-Carboxaldehyde-4-Phenyl-3-Thiosemicarbazone
A new quinoline–thiosemicarbazone derivative, 5,7-dichloro-8-hydroxyquinoline-2-carboxaldehyde-4-phenyl-3-thiosemicarbazone (QPS) and seven complexes...
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Antiproliferative Activity of N-Substituted 2,4-Diamino-5-Aryl-5,6,7,8,9,10-Hexahydrobenzo[B][1,8]Naphthyridine-3-Carbonitriles
Th antiproliferative activity of N -substituted 2,4-diamino-5-aryl-5,6,7,8,9,10-hexahydrobenzo[ b ][1,8]naphthyridine-3-carbonitriles was studied....
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Synthesis and Antiproliferative Activity of New N-Acylhydrazone Derivatives Containing Benzothiazole and Indole Based Moiety
Through a structure-based molecular hybridization strategy, a series of new N -acylhydrazone derivatives containing the benzothiazole and indole based...
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Synthesis of Some 2-Substituted-5-(Benzothiazol-2-yl)-1H-Benzimidazole Derivatives and Investigation of Their Antiproliferative Effects
In addition to methods such as radiotherapy and surgery, another effective way that is preferred for the treatment of cancer is based on the use of...
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Anticancer Activity–Structure Relationship of Quinolinone-Core Compounds: An Overall Review
Quinolinone/quinoline is one of the most unique structures in the discovery of heterocycles that have attracted much attention in the field of...
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Cytotoxic Activity of Pimpinella isaurica and In Silico Analysis of Flavonoids
Pimpinella L., Apiaceae, is one of the largest genera and has a broad spectrum of biological or pharmacological activities including...
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Synthesis and Antiproliferative Activity of Isolongifolanone Pyrazoline Derivatives Inducing Intracellular ROS Accumulation
A series of new isolongifolanone pyrazoline derivatives were synthesized and characterized by 1H NMR and HRMS methods. The compounds were assessed...
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Antiproliferative Activity of 2-Halo-5,6-Dihydropyridine- and 2-Halo-4A,5,6,7-Tetrhydroquinoline-3,4,4(1H )-Tricarbonitriles
The antiproliferative activity of 2-halo-5,5-dialkyl-6-methoxy(hydroxy)-5,6-dihydropyridine-3,3,4(1 H )-tricarbonitriles and their analogs...
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Antiproliferative Activity of 2-Aroyland 2-Heteroyl-1,1,3,3-Tetracyanoprop-2-en-1-ides
The influence of previously synthesized 2-aroyl-1,1,3,3-tetracyanoprop-2-en-1-ides on the growth of conditionally normal and tumor cells was studied...
