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Synthesis and Antiaggregant and Anticoagulant Activity of Amino-Acid Salts and Computer Simulation of the Interaction of Their Structures with the Surface of Cyclooxygenase
Effective drugs with antiaggregant and anticoagulant activity are known to possess side effects. It was hypothesized that compounds synthesized from...
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Synthesis and Antiplatelet and Anticoagulant Activity of Thietane-Containing 2-(5-Bromo-2,4-Dihydro-3-Oxo-1,2,4-Triazolyl-4)Acetate Salts
Sulfone II was synthesized via oxidation of ethyl 2-[5-bromo-2,4-dihydro-3-oxo-2-(thietanyl-3)-1,2,4-triazolyl- 4]acetate ( I ) by H 2 O 2 . Hydrolysis of...
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Synthesis and Antiaggregant and Anticoagulant Activity of New 1-(4-Alkyloxybenzyl)-1H-Azoles and 1-(Adamantyl-1)-2-[4-(1H-Azol-1-Ylmethyl)-Phenoxy]Ethanones
The development and optimization of synthetic methods for alkyl esters of 4-[(1 H -azol-1-yl)methyl]phenols enabled the expansion of organic synthesis...
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Antithrombotic Activity of the Steroids and ent-Kaurane Diterpenoids from Canna indica Rhizomes
Canna indica L . Cannaceae, is a valuable plant used for the treatment of many conditions. However, the scientific evidence to support the traditional...
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Molecular Weight Characteristics and Anticoagulant Activity of Low-Molecular-Weight Heparin Obtained By Nitrous Acid Depolymerization
Low-molecular-weight heparin was synthesized by depolymerization of high-molecular-weight heparin with nitrous acid. Preparative chromatography was...
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Synthesis and Biological Activity of 2-(3,3-Dimethyl-6,7-Diethoxy-3,4-Dihydroisoquinolin-1-yl)Carboxylic Acid Hydrochlorides and Their Benzo[f]-Analogs
Ritter reactions of 1-(3,4-diethoxyphenyl)-2-methylpropanol-2 with 2-alkylcyanoacetamides (alkyl = Et, n -Pr, n -Bu, n -Am, i -Am) were used to...
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Synthesis and Biological Activity of 5-alkoxy- and 5-amino-substituted 3-bromo-4-nitro-1-(thietan-3-yl)-1H-pyrazoles
5-Alkoxy- and 5-amino-substituted 3-bromo-4-nitro-1-(thietan-3-yl)-1 H -pyrazoles were synthesized by reactions of...
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Synthesis and In Vitro Study of the Anticoagulation and Antiplatelet Activity of Abietic and Maleopimaric Acid Amides
The main goal of applying antiplatelet drugs is a reduced probability of thrombosis so that active substances that are superior to reference drugs in...
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Nanoemulsion Improves the Anti-inflammatory Activity of Carvacrol upon Oral Administration
Carvacrol is the main phenolic monoterpene isolated from the essential oils of plants from the genus Origanum L., Lamiaceae. Carvacrol has several...
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BIOLOGICAL ACTIVITY OF COMPOUNDS OF PLANT ORIGIN
Due to their structural diversity and specific biological effects, natural substances play an important role in medication. Many of the medicines...
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Method for Obtaining and Hypolipidemic Activity Assay of a Lipolytic Enzyme from Nigella sativa Seeds
A lipolytic enzyme was isolated from seeds of Nigella sativa after pressing the oil to develop a waste-free technology. An enzyme with a maximum...
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Wound-Healing Activity and Acute and Chronic Toxicity of a Gel Based on Guanidine-Containing Pectin Derivatives
Results of an investigation of the wound-healing activity and toxicity parameters of a gel based on guanidine-containing pectin derivatives are...
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Structure and Biological Activity of Galactomannans from Seed Pods of Two Crotalaria Species
Water-soluble polysaccharides and pectinic substances from seed pods of Crotalaria alata L. (Uzbekistan) and Crotalaria sp. (India) were studied. The...
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Synthesis of 3,3-Dimethyl- and 3,3-Diethyl-Substituted 2-(3,4-Dihydroisoquinolin-1-yl)Carboxylic Acid Amide Hydrochlorides and Their Anti-Arrhythmic, Hemostatic, Anthelmintic, and Larvicidal Activity
Series of 3,3-dimethyl- and 3,3-diethyl-substituted 2-R-(3,4-dihydroisoquinolin-1-yl)acetamides were synthesized via Ritter reactions of...
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Synthesis, Anti-Arrhythmic, Hemostatic, Anthelmintic, and Larvicidal Activity of 2-(3-spiro-cycloalkyl-3,4-dihydroisoquinolin-1-yl)-Carboxylic Acid Amide Hydrochlorides
A series of nine 2-(3-spiro-cycloalkyl-3,4-dihydroisoquinolin-1-yl)carboxylic acid amide hydrochlorides were synthesized using Ritter cyclization of...
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Inhibition of Metalloproteinase from Bitis arietans Venom In Vitro by the Ethyl Acetate Fraction of Moringa oleifera and Its Chemical Profile
Moringa oleifera Lam., Moringaceae, ethyl acetate soluble fraction has been documented to contain bioactive antivenom chemicals against Bitis arietans ...
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Antiarrhythmic, Hemostatic, Anthelmintic, and Larvicidal Activity of 3,3-Dialkyl-Substituted Drotaverine Analogs
Previously obtained hydrochlorides of 1-[3,4-(R 1 ) 2 -benzyl]-3,3-(R 2 ) 2 -6,7-(R 3 ) 2 -3,4-dihydroisoquinolines (R 1 = H, MeO, EtO; R 2 = Alk; R 3 = MeO, EtO)...
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Synthesis, Antimicrobial Activity, α-Amylase Inhibitory Tests and Molecular Docking Studies of Thiazole Based Hydrazones Derived from 2-acyl-(1H)-indene-1,3(2H)-diones
A series of new thiazole based hydrazones have been synthesized and their antimicrobial and α-amylase (type-II diabetes) inhibitory activities have...
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Synthesis and Antiarrhythmic, Hemostatic, Anthelmintic, and Larvicidal Activity of (3,3-Dialkyl-6,7-Diethoxy-3,4-Dihydroisoquinolin-1(2H)-Ylidene)Acetamide Hydrochlorides
A series of (3,3-dialkyl-6,7-diethoxy-3,4-dihydroisoquinolin-1(2 H )-ylidene)acetamide hydrochlorides were synthesized via Ritter cyclocondensation of...
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Synthesis of New N-Mono- and N,N-Dialkylated Imidazole Derivatives and Their Antiplatelet and Anticoagulation Activity
Currently there are several effective synthetic methods for preparing various N -mono- and N , N -dialkylated imidazole derivatives with a very wide...
