Search
Search Results
-
Anticancer effect of terpenes: focus on malignant melanoma
Melanoma is a highly aggressive and life-threatening form of skin cancer that accounts for a significant proportion of cancer-related deaths...
-
Ubiquitin–proteasome system as a target for anticancer treatment—an update
As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the dysregulation or aberrant expression of the UPS components...
-
Ginsenoside Rg5 as an anticancer drug: a comprehensive review on mechanisms, structure–activity relationship, and prospects for clinical advancement
Cancer remains one of the leading causes of death in the world. Despite the considerable success of conventional treatment strategies, the incidence...
-
Anticancer Activity–Structure Relationship of Quinolinone-Core Compounds: An Overall Review
Quinolinone/quinoline is one of the most unique structures in the discovery of heterocycles that have attracted much attention in the field of...
-
Galangin, as a Potential Anticancer Agent
Cancer is a major global health issue and one of the main causes of mortality worldwide. In recent years, cancer mortality and morbidity rates have...
-
A pharmacist check of patients’ infection-related condition prior to drug preparation reduces anticancer drug wastage after mixing: a retrospective study
BackgroundWe previously reported that a standardized pharmacist check of medical orders related to the administration criteria of anticancer drugs...
-
Piperazine Heterocycles as Potential Anticancer Agents: A Review
Cancer is a rapid, out of control, and proliferation pathology of ordinary cells, which has become one of the most infamous and aggressive health...
-
Latest research progress on anticancer effect of baicalin and its aglycone baicalein
Cancer, which is a leading cause of deaths around the world, is characterized by genetic mutations and epigenetic changes. Baicalin and its aglycone...
-
Synthesis of Au–Ag bimetallic nanoparticles using Korean red ginseng (Panax ginseng Meyer) root extract for chemo-photothermal anticancer therapy
Green synthesis strategies have been widely applied for the preparation of versatile nanomaterials. Gold nanospheres with an average size of...
-
RETRACTED ARTICLE: Synthesis, Pharmacological Evaluation, and Molecular Modeling Studies of New Isatin Hybrids as Potential Anticancer Agents
A new series of isatin hybrids ( 5a–5g ) were designed, synthesized, and characterized spectroscopically. The synthesized compounds were evaluated for...
-
Impact of the US Accelerated Approval for New Anticancer Drugs on Time to Verification of Benefit and Regulatory Approval in the EU and Japan
The accelerated approval (AA) program in the USA has succeeded in expediting the regulatory approval of new cancer drugs based on surrogate endpoint...
-
Cascade Synthesis of 1,4-Butanediol Monomesylate Glycoconjugates: Anticancer Candidates for Leukemia
Acascade synthesis protocol for glycosides of 1,4-butanediol monomesylate, as anticancer drug candidates, is proposed. All obtained compounds are...
-
Characteristics of Anticancer Drugs Approved Under the Accelerated Approval Program in the US: Success or Failure in Converting to Regular Approval
BackgroundAccelerated approval (AA) program expedites access to promising drugs for life-threatening conditions, particularly in oncology. However,...
-
Crystal Structure, Anticancer, and Antimicrobial Evaluation of a Novel Substituted Pyrazole Ligand and Its Co(II), Ni(II), and Zn(II) Complexes
Synthesis of substituted heterocyclic organic ligands and their metal complexes attract more attention in coordination chemistry in recent years...
-
Healthy Volunteer Studies in the Development of Anticancer Drugs with Genotoxic Findings
BackgroundRecent scientific advances in cancer research have led to the development of immunomodulatory and molecularly targeted drugs with better...
-
Pharmacological Strategies to Overcome Tumor Resistance to Anticancer Hormonal, Targeted, and Immunotherapy
Possible molecular mechanisms of develo** tumor drug resistance to anticancer hormonal, targeted, and immunotherapy that are associated with the...
-
Design, Synthesis and Biological Evaluation of Amide Derivatives of Thiazole-Indole-Isoxazoles as Anticancer Agents
A new library of amide derivatives of thiazole-indole-isoxazoles 11a-j has been prepared and their structures were confirmed by analytical data....
-
Cardiotoxicity linked to anticancer agents and cardioprotective strategy
Chemotherapy is a main treatment for cancer, and it benefits patients by controlling cancer relapse and metastasis, thereby leading to an increase in...
-
Development of Fused and Substituted Pyrimidine Derivatives as Potent Anticancer Agents (A Review)
The pyrimidine scaffold is a versatile lead heterocycle in pharmaceutical development. It has diverse chemical reactivity, accessibility and a wide...
-
Androgen receptor and hyaluronan-mediated motility receptor as new molecular targets of baicalein: new molecular mechanisms for its anticancer properties
Natural compounds known as phytochemicals have served as valuable resources for the development of new anti-cancer drugs and treatment of...
