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Multi-layered metabolic effects of trehalose on the liver proteome in apoE-knockout mice model of liver steatosis
BackgroundMetabolic dysfunction-associated fatty liver disease has been well documented as a key independent risk factor for the development of...
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Synthesis and Antiaggregant Activity of 2-[3-Methyl-1-Ethylxanthinyl-8-Thio]Acetic Acid Salts Containing a Thietane Ring
Reaction of 7-(thietanyl-3)-, 7-(1-oxothietanyl-3)-, and 7-(1,1-dioxothietanyl-3)-8-bromo-3-methyl-1-ethylxanthines with thioglycolic acid produced...
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Tropoxin – Drug for the Treatment of Migraine
Anew antimigraine drug – Tropoxin (3-(3,4,5-trimethoxybenzoyloxyimino)-8-methyl-8-azabicyclo[
1 –3 ]octane hydrochloride) – was developed and was found...
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The Search for Pharmacologically Active Compounds Among the 2-Dialkylaminobenzimidazoles
Heating of substituted benzimidazole-2-sulfonic acids in the presence of excess quantities of secondary amines was used to synthesize...
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Induction of apoptosis by Moutan Cortex Radicis in human gastric cancer cells through the activation of caspases and the AMPK signaling pathway
Moutan Cortex Radicis , the root bark of Paeonia × suffruticosa Andrews, Paeoniaceae, has been widely used in traditional medicine therapy. Although...
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Pharmacological modulation of fibrinolytic response — In vivo and in vitro studies
Fibrinolysis is an action of converting plasminogen by its activators, like tissue- or urokinase-type plasminogen activators (t-PA, u-PA), to...
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Impact of aliskiren on some hemostatic parameters in experimental arterial thrombosis in rats
BackgroundAliskiren is the first orally active inhibitor of renin to be approved for clinical use as an antihypertensive agent. A number of studies...
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Mydriasis model in rats as a simple system to evaluate α2-adrenergic activity of the imidazol(in)e compounds
Imidazol(in)e compounds show the diversity of pharmacological effects including mydriasis, hypotension, sedation, bradycardia and hypothermia. At...
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Effects of nitrosyl complexes of iron with functional S-ligands on the activity of hydrolytic enzymes
We report here our studies of new nitrosyl complexes of iron of the cationic type - [Fe 2 (SR′) 2 (NO) 4 ] 2+ with R′ = cysteamine and penicillamine - and...
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Some chemical and biochemical aspects of the problem of atherosclerosis
This review summarizes the most important data relating to the chemical and biological aspects of the problem of atherosclerosis – one of the most...
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Comparative effects of β-carbolines on platelet aggregation and lipid membranes
The effects of 14 β-carbolines on human platelet aggregability were comparatively studied, and the effects on lipid membranes were determined....
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Transcellular biosynthesis of eicosanoids
The metabolism of arachidonic acid into biologically active compounds involves the sequential activity of a number of enzymes, sometimes showing a...
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Synthesis and procoagulatory activity of n-(6-methyl-3-cyano-5-ethoxycarbonyl-2-pyridyl) aminoalkanecarboxylic acids
Interaction of 6-methyl-2-chloro-3-cyano-5-ethoxycarbonylpyridine with potassium salts of amino acids was shown to form...
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Pharmacological activity of 16-and 18-member dibenzodioxatetraaza macroheterocyclic compounds
The spectrum of the biological activities (within the framework of the PASS program) that 16-and 18-member dibenzodioxatetraaza macroheterocyclic...
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Platelet Glycoprotein IIb/IIIa Polymorphism and Coronary Artery Disease
Membrane glycoprotein (GP) IIb/IIIa plays a major role in platelet function; indeed it enables stimulated platelets to bind fibrinogen and related...
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Olea europaea
Olea europaea is a large evergreen shrub of the OLEACEAE family. In its native state, it is a multistemmed evergreen tree, 6–9 m...
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Effect of vehicles and enhancers on thein vitro skin penetration of aspalatone and its enzymatic degradation across rat skins
The feasibility of skin penetration was studied for aspalatone (AM, acetylsalicylic acid maltol ester), a novel antithrombotic agent. In this study,...
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Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities
Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to...