Search
Search Results
-
Integration of Antioxidant Activity, Affinity Ultrafiltration, and Molecular Docking Simulations to Decipher the Tyrosinase Inhibitor of Embelia laeta
Embelia laeta (L.) Mez., Primulaceae, is mostly used by Chinese ethnic minorities. However, only little is known about its antioxidant chemical...
-
Liposomal Pharmaceutical Products: Methods of Analytical Characterization and Quality Control
Modern methods of analytical characterization and quality control of liposomal pharmaceutical products are reviewed. Analytical studies are shown to...
-
Influence of Manufacturing Technology on the Properties of Active Pharmaceutical Ingredients of Prostate Extract
Important peculiarities of various technologies used for manufacturing the API of prostate extract that determine different qualitative...
-
Peptide Composition and Identification of a Peptide with Anti-Inflammatory and Antiplatelet Properties in Cattle Prostate Extract
An attempt to identify the peptide structure of bovine prostate extract using water/vinegar technology followed by tangential ultrafiltration is...
-
Therapeutic Proteins and Advanced Therapy Medicinal Products
This chapter is divided in two parts: Therapeutic proteins and Advanced Therapy Medicinal Products (ATMPs)....
-
Development of a Pharmaceutical Composition and Stablity of Liquid Dosage Forms Based on Monoclonal IgG1 Antibodies
A scheme for develo** an excipient composition for liquid dosage forms based on monoclonal antibodies(mAbs) is proposed and used to develop a...
-
Characterization of the von Willebrand factor/factor VIII complex produced by a novel purification process
Factor VIII (FVIII) is a blood coagulation protein that circulates as a complex with von Willebrand factor (vWF) in the plasma. In the survey of...
-
The influence of cyclooxygenase inhibitors on kynurenic acid production in rat kidney: a novel path for kidney protection?
BackgroundKidney diseases have become a global health problem, affecting about 15% of adults and being often under-recognized. Immunological system...
-
Function and therapeutic development of exosomes for cancer therapy
Exosomes are extracellular vesicles, 50–150 nm in diameter, released by most cells. Exosomes contain several intracellular components, including DNA,...
-
Concentration of meropenem in patients with sepsis and acute kidney injury before and after initiation of continuous renal replacement therapy: a prospective observational trial
BackgroundThe effect of renal replacement therapy on drug concentrations in patients with sepsis has not been fully elucidated because the...
-
Parenteral
This chapter gives an overview of parenteral dosage forms and the rationale for their use. Parenterals are sterile preparations that are injected...
-
Gastric cancer and mesenchymal stem cell-derived exosomes: from pro-tumorigenic effects to anti-cancer vehicles
Gastric cancer (GC) is one of the most prevalent malignancies in the world, with a high mortality rate in both women and men. Conventional...
-
Isolation and Characterization of Antimicrobial Peptides from Bos taurus Bone Marrow
Polypeptides from Bos taurus bone marrow (BBM) were purified for the first time using ultrafiltration and two-stage ion-exchange chromatography....
-
Low Molecular Weight Fucoidan from Saccharina Japonica Ameliorates the Antioxidant Capacity and Reduces Plaque Areas in Aorta in Apoe-Deficient Mice with Atherosclerosis
Low molecular weight fucoidan (LMWF) extracted from Saccharina japonica exhibits many biological activities including immune regulation and...
-
Isolation and Purification of Active Proteases from Sheep Abomasum and Their Biological Activity
Sheep abomasum active proteases (SAPs) were purified by chromatography over a column of Sephadex G-25 and by ultrafiltration. The SAPs were found to...
-
Determination and validation of LJ-2698, a potent human A3 adenosine receptor antagonist, in rat plasma by liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic study
LJ-2698, a highly potent human A 3 adenosine receptor antagonist with nucleoside structure, was designed to have a minimal species dependence. For...
-
Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Emerging Lipid Based Drug Delivery Systems
In the past decade, research in the area of nanodrug delivery has reached a new height with the advent of lipid based nanodrug delivery systems....
-
Ultrafiltration-Based Extraction and HPLC Analysis of Naproxen Sodium in Human Plasma Samples: an Innovative Approach to Pharmaceutical Analysis
The purpose of this study was to assess the possibility of using ultrafiltration-based extraction for pharmaceutical analysis and develop an...
-
Technological Aspects of Ensuring the Specific Safety of Human Immunoglobulin and Albumin Preparations
Modern technological approaches to ensuring the specific safety of human immunoglobulin and albumin preparations are analyzed. Introduction into...