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Synthesis and Antidepressant Activity of 5-Amine-Substituted 3-Bromo-1-(1,1-Dioxothietan-3-yl)-4-Nitro-1H-Pyrazoles
5-Amino-substituted 3-bromo-1-(1,1-dioxothietan-3-yl)-4-nitro-1 H -pyrazoles were synthesized via the reactions of...
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Synthesis and Antidepressant Activity of 4-Alkyl-5-Bromo-2,4-Dihydro-2-(Thietan-3-YL)-1,2,4-Triazol-3-Ones
A series of 4-alkyl-5-bromo-2,4-dihydro-2-(thietan-3-yl)-1,2,4-triazol-3-ones ( IIa - g ) were synthesized by reacting...
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Quantitative Structure–Activity Relationship Analysis and Validation of New DNA Gyrase Inhibitors
Quantitative structure–activity relationship (QSAR) analysis was carried out for a series of 61 compounds with thiazole and benzthiazole moiety for...
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(–)-cleistenolide and its Analogs as New Potential Antitumor Compounds Against PC-3 Cells
In order to find and develop new active compounds against prostate cancer, (–)-cleistenolide ( 1 ) and its 24 new analogs were evaluated for in vitro ...
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Synthesis and Antidepressant Activity of Thietane-Containing 4-(2-oxo-2-phenylethyl)-1H-1,2,4-triazol-4-ium Bromides
Thietane-containing 4-(2-oxo-2-phenylethyl)-1 H -1,2,4-triazol-4-ium bromides were synthesized by quaternization of thietanyltriazoles with phenacyl...
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Study on Horizon Scanning with a Focus on the Development of AI-Based Medical Products: Citation Network Analysis
Horizon scanning for innovative technologies that might be applied to medical products and requires new assessment approaches to prepare regulators,...
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Horizon Scanning in Tissue Engineering Using Citation Network Analysis
BackgroundEstablishing a horizon scanning method is critical for identifying technologies that require new guidelines or regulations. We studied the...
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Anti-hepatic Fibrosis Potential of Ailanthone, A Quassinoid Isolated from Ailanthus altissima
Ailanthone is an active ingredient isolated from Ailanthus altissima (Mill.) Swingle, Simaroubaceae, which is a traditional medicine widely used in...
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Ethionamide and Prothionamide Based Coumarinyl-Thiazole Derivatives: Synthesis, Antitubercular Activity, Toxicity Investigations and Molecular Docking Studies
The goal of this research work was to prepare and evaluate the antitubercular (anti-TB) activity of ethionamide (ETH) and prothionamide (PTH) based...
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Synthetic Clubbing of 2-Methyl-5-Nitroimidazole with 5(6)-Substituted-1H-Benzimidazole as Potential Antimicrobial and Anthelmintic Agents
In search for new potent antimicrobials and anthelmintics, 5(6)-substituted-1 H -benzimidazole substituted 2-methyl-5-nitroimidazole derivatives ( 1a–1g )...
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Annonaceae Terpenoids as Potential Leishmanicidal Agents
Leishmaniasis is a neglected tropical disease caused by protozoa of the genus Leishmania . Current drug treatments for leishmaniasis are outdated and...
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L-proline transporter inhibitor (LQFM215) promotes neuroprotection in ischemic stroke
BackgroundL-proline transporter (PROT/SLC6A7) is closely associated with glutamatergic neurotransmission, where L-proline modulates the NMDA receptor...
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Synthesis, Antimicrobial Activity and QSAR Studies of Some New Sparfloxacin Derivatives
The increasing global health problem of bacterial resistance to the major classes of antibiotics is driving scientists to search for newer...
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Synthesis, Antidepressant Activity, and Prediction of Toxic Risks of 3-Alkoxy(Sulfanyl)Thietane-1,1-Dioxides
A series of 3-alkyloxy(sulfanyl)thietane-1,1-dioxides were synthesized by reacting 3,5-dibromo-1-(1,1-dioxothietanyl- 3)-1,2,4-triazole with sodium...
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Liquid Crystals: Characteristics, Types of Phases and Applications in Drug Delivery
The present review article relates to some theoretical aspects of liquid crystals, particularly types and phases of liquid crystals. In recent years...
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Anti-inflammatory activity of novel thiosemicarbazone compounds indole-based as COX inhibitors
BackgroundIn this article, a series of 20 new thiosemicarbazone derivatives containing indole were synthesized and evaluated for their...
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Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Emerging Lipid Based Drug Delivery Systems
In the past decade, research in the area of nanodrug delivery has reached a new height with the advent of lipid based nanodrug delivery systems....
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Design, synthesis and evaluation of 5-substituted 1-H-tetrazoles as potent anticonvulsant agents
AbstractA series of 5-substituted 1- H -tetrazoles were designed and synthesized as potent anticonvulsant agents. Their preliminary anticonvulsant...
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QSAR based therapeutic management of M. tuberculosis
Mycobacterium tuberculosis is responsible for severe mortality and morbidity worldwide but, under-developed and develo** countries are more prone...
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3-Substituted Thietane-1,1-Dioxides: Synthesis, Antidepressant Activity, and in Silico Prediction of Their Pharmacokinetic and Toxicological Properties
3-Aryloxy- and 3-phenylsulfanylthietane-1,1-dioxides were synthesized by reacting 3,5-dibromo-1-(1,1-dioxothietan-3-yl)-1,2,4-triazole with sodium...
