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Distinctive role of inflammation in tissue repair and regeneration
Inflammation is an essential host defense mechanism in response to microbial infection and tissue injury. In addition to its well-established role in...
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Effect of heme oxygenase-1 on the differentiation of human myoblasts and the regeneration of murine skeletal muscles after acute and chronic injury
BackgroundImpaired muscle regeneration is a hallmark of Duchenne muscular dystrophy (DMD), a neuromuscular disorder caused by mutations in the DMD ...
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Horizon Scanning in Tissue Engineering Using Citation Network Analysis
BackgroundEstablishing a horizon scanning method is critical for identifying technologies that require new guidelines or regulations. We studied the...
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The essential role of TAZ in normal tissue homeostasis
Transcriptional coactivator with PDZ-binding motif (TAZ) has been extensively characterized in organ development, tissue regeneration, and tumor...
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Pharmacokinetics and Tissue Distribution of Oxidized and Reduced Coenzyme Q10 Upon Intravenous Administration
Drugs containing coenzyme Q10 (CoQ10) in the oxidized (ubiquinone) or reduced forms (ubiquinol) are used to treat diseases associated with redox...
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Nanocurcumin: its Applications in Preventive, Restorative, and Regenerative Dentistry
Curcumin, a natural biphenolicdiaryl heptanoid, is known to have a wide range of therapeutic dental applications due to its variety of biological and...
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Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression
Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming an increasingly pressing global health challenge, with increasing...
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EGF, a veteran of wound healing: highlights on its mode of action, clinical applications with focus on wound treatment, and recent drug delivery strategies
Epidermal growth factor (EGF) has been used in wound management and regenerative medicine since the late 1980s. It has been widely utilized for a...
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DPP4 inhibitor induces beta cell regeneration and DDR-1 protein expression as an endocrine progenitor cell marker in neonatal STZ-diabetic rats
BackgroundWe aim to investigate the effects of dipeptidyl-peptidase-4 inhibitor (Vildagliptin-VG) on DDR-1 as a marker for endocrine progenitor...
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Elucidating the Osteogenic Potential of Naringin and Naringin–Cu(II) Complex: a Comprehensive In Vitro and In Vivo Study
This study investigates the molecular impact of naringin and naringin–Cu(II) complex on osteoblast differentiation using human osteoblastic cells and i...
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Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
Fibrosis, the excessive deposition of fibrous connective tissue in an organ in response to injury, is a pathological condition affecting many...
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Rosmarinus officinalis Volatile Oil Nanogel Modulated Muscle Damage Induced by Bothrops moojeni Venom: a Phonophoresis Method
Bothrops moojeni venom contains toxins that induce local toxic effects, leading to a severe inflammatory process, pain, hemorrhage, edema, and...
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Biopharmaceutical, Toxicological, and Morphological Assessment of an Antiallergenic Medicine for External Application
This report addresses studies of the release of active ingredients (diphenhydramine and fluconazole) from a gel base for a medicine for external...
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Advanced Formulation Approaches for Emerging Therapeutic Technologies
In addition to proteins, discussed in the Chapter “Advances in Vaccine Adjuvants: Nanomaterials and Small Molecules”, there are a wide range of...
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The emerging role of mechanical and topographical factors in the development and treatment of nervous system disorders: dark and light sides of the force
Nervous system diseases are the subject of intensive research due to their association with high mortality rates and their potential to cause...
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Therapeutic implication of Sonic Hedgehog as a potential modulator in ischemic injury
Sonic Hedgehog (SHh) is a homology protein that is involved in the modeling and development of embryonic tissues. As SHh plays both protective and...
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The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is a persistent metabolic disorder marked by deficiencies in insulin secretion and/or function, affecting various...
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Drug repositioning: diacerein as a new therapeutic approach in a mice model of sciatic nerve injury
BackgroundPeripheral nerve injuries negatively impact the quality of life of patients, with no effective treatment available that accelerates...
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Targeting Endothelial Progenitor Cells Reparative Potential Via Canonical Wnt/NOX-4 Signaling Pathway in Rats Dyslipidemia: Role of Resveratrol
Signaling pathways guiding the reparative function of endothelial progenitor cells (EPCs) are complex. Conflicts involve the double-face role of...
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Melatonin and oral diseases: possible therapeutic roles based on cellular mechanisms
Oral diseases, including periodontal disorders, oral cancer, periodontitis, and mucositis are the major challenges for both patients and healthcare...
