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Evaluation and Analysis of Mathematical Models of Heat-Transfer Processes Occurring Upon Application of Film Coatings on Biconvex Tablets
Approaches to mathematical modeling of heat-transfer processes occurring upon application of film coatings to biconvex tablets are reviewed....
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Formulation Design for Freeze-Drying: Case Studies of Stabilization of Proteins
Formulation design is an integral part of drug product development for parenterally applied dosage forms. In particular for freeze-dried... -
Brazilian Medicinal Plants with Antiamyloidogenic Activity
Amyloid fibrillation is a process involved in a large set of pathologies, including diabetes and Alzheimer’s. Although Brazil has a large...
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Comparative Evaluation of the Pharmacological Activity of Fatty Aromatic Amides and Amines with a Framework Moiety and Their Non-Covalent Complexes
Pharmacological studies of the new fatty-aromatic amides, structural analogs of chlorobenzoylaminoadamantane (chlodantane), and non-covalent...
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Common Deficiencies Found in the Active Pharmaceutical Ingredient (API) Section of Non-sterile Generic Products Submitted for Registration by SAHPRA
PurposeThis research study aims to determine the qualitative and quantitative common deficiencies included in the API section of dossiers submitted...
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In Vivo Testing and Extended Drug Release of Chitosan-Coated Itraconazole Loaded Microemulsion Using Volatile Oil Thymus vulgaris
Microemulsions are potent drug delivery vehicles as they solubilize water insoluble drugs with poor bioavailability. The main aim of this study was...
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Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin–angiotensin–aldosterone system pathway, and...
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Therapeutic Proteins and Advanced Therapy Medicinal Products
This chapter is divided in two parts: Therapeutic proteins and Advanced Therapy Medicinal Products (ATMPs).... -
BIOSYNTHESIS OF PLANT SUBSTANCES; BIOGENETIC RELATIONSHIPS
The bioactive substances in medicinal plants will be discussed on the basis of their chemical structure, or more precisely, of a... -
From Relative to Absolute Stereochemistry of Secondary Metabolites: Applications in Plant Chemistry
Structural elucidation of specialized metabolites or natural plant products, especially the stereochemical features of chiral bioactive metabolites,...
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Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Emerging Lipid Based Drug Delivery Systems
In the past decade, research in the area of nanodrug delivery has reached a new height with the advent of lipid based nanodrug delivery systems....
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Biophysical Considerations for Development of Antibody-Based Therapeutics
Development of therapeutic monoclonal antibodies requires rigorous measurements of the kinetic and thermodynamic binding properties of... -
Antioxidant and Antiradical Activity of Drugs Intended for Treating Ophthalmic Disorders
Dosage forms intended for ophthalmic use with declared and potential antioxidant properties were investigated. Antioxidant activity was determined...
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Dehydration of 9a-Hydroxyandrost-4-ene-3,17-Dione in Organic Solvents
An effective method of dehydrating 9_-hydroxyandrost-4-ene-3,17-dione by mineral acids in organic solvents, producing essentially quantitative...
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Controlled-Release Matrixes for Drugs Based on Polyamide-Polyhydroxybutyrate Compositions
The transport properties of films based on poly(3-hydroxybutyrate) (PHB) and polyamide were studied. The factor responsible for the rate of...
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Application of ionic liquid to polymorphic transformation of anti-viral/HIV drug adefovir dipivoxil
Ionic liquids (ILs) are defined as salts with a melting point below 100 °C. ILs have received increasing attention as new alternative to organic...
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Experimental and Theoretical Justification for the Regiospecific Cycloaddition of Levopimaric Acid to 2-Acetyl- or 2-(Methoxycarbonyl)-1,4-Benzoquinone
New 4a-quinopimaric acid derivatives were synthesized via a Diels–Alder reaction of levopimaric acid with 2-acetyl- or...
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Investigation of early and advanced stages in ovarian cancer using human plasma by differential scanning calorimetry and mass spectrometry
Ovarian cancer is recognized with high mortality due to asymptomatic nature of the disease and difficulties in diagnosing early stage of the cancer....
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Formulation development and in vivo hepatoprotective activity of self nanoemulsifying drug delivery system of antioxidant coenzyme Q10
Coenzyme Q 10 (CQ 10 ) is known as an endogenous cellular antioxidant, naturally found in every cell of the human body and plays an important role in...
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Energetics of Clouding Phenomenon in Amphiphilic Drug Imipramine Hydrochloride with Pharmaceutical Excipients
The clouding behaviour of an amphiphilic antidepressant drug imipramine hydrochloride (IMP) with several additives (hydrotropes, bile salts, fatty...