Search
Search Results
-
Toxicity and Antihypoxic Activity of a Preparation Containing a Complex Compound of 5-Hydroxy-6-Methyluracil with N-Acetyl Cysteine
5-Hydroxy-6-methyluracil (5-OH-6-MU) was shown to form a 1:1 complex with N -acetylcysteine (N-AC), i.e., the compounds interacted in an equimolar...
-
Laser-Based Headspace Moisture Analysis for Rapid Nondestructive Moisture Determination of Lyophilized Products
Residual moisture content is a critical quality parameter for freeze-dried pharmaceutical product and exists in different forms. Only the relatively...
-
Evaluation and Analysis of Mathematical Models of Heat-Transfer Processes Occurring Upon Application of Film Coatings on Biconvex Tablets
Approaches to mathematical modeling of heat-transfer processes occurring upon application of film coatings to biconvex tablets are reviewed....
-
Beyond pH: Acid/Base Relationships in Frozen and Freeze-Dried Pharmaceuticals
Stability of the majority of pharmaceuticals and biopharmaceuticals depends on acidity/basicity of the environment. In aqueous solutions,...
-
Comparative study of the binding between chlorogenic acid and four proteins by isothermal titration calorimetry, spectroscopy and docking methods
AbstractAs a polyphenolic compound, chlorogenic acid has antioxidant, anti-inflammatory, antiviral, anti-obesity and other effects. Based on the...
-
Formulation Design for Freeze-Drying: Case Studies of Stabilization of Proteins
Formulation design is an integral part of drug product development for parenterally applied dosage forms. In particular for freeze-dried...
-
Studies on the Potential Vehicles (Co-Vehicles) for Formulating Intranasal Solution of Lamotrigine
Lamotrigine, an antiepileptic agent belonging to class II of the Biopharmaceutical Classification System (BCS), has linear pharmacokinetics and wide...
-
Stresses, Stabilization, and Recent Insights in Freezing of Biologics
Freeze-thawing is a critical unit operation during manufacturing of biopharmaceuticals. A significant fraction of biologics drug substances are...
-
Overview of Freeze Drying
Freeze drying which is also termed as lyophilization is one of the drying technologies that is commonly used to enhance the storage stability of...
-
Recent Formulation Advances of Mangiferin
Nutraceuticals have recently gained interest owing to their valuable contribution in the treatment of several diseases, with high safety margin and...
-
Application of PAT in Real-Time Monitoring and Controlling of Lyophilization Process
This chapter provides a description of the motivation for the development and application of real-time, online process monitoring techniques for...
-
Permeability Enhancers in Transdermal Delivery System Technology (Review)
Transdermal delivery of drugs is a current alternative route of administration for systemic actions because of a whole series of unarguable...
-
A Potentially Alternative Route to Predict Crystal Morphologies of Indicaxanthin Crystals
Due to several failed attempts to crystallize indicaxanthin, a powerful antioxidant belonging to the vast family of betalains, its ab initio crystal...
-
Design and Preparation of Iodinated Brucea Javanica Oil as Dual Functional Anti-Tumor Agent for Treating Hepatocellular Carcinoma
Brucea javanica oil (BJO), a traditional herbal medicine extracted from the seeds of Brucea javanica plant, has been used in the treatment of cancer...
-
Freeze-Drying of Thermosensible Pharmaceuticals with Organic Co-solvent + Water Formulations
The organic co-solvent + water formulations present many interesting advantages for the freeze-drying of thermosensible drugs to produce stabilized...
-
EGF, a veteran of wound healing: highlights on its mode of action, clinical applications with focus on wound treatment, and recent drug delivery strategies
Epidermal growth factor (EGF) has been used in wound management and regenerative medicine since the late 1980s. It has been widely utilized for a...
-
Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin–angiotensin–aldosterone system pathway, and...
-
Effect of tricyclic 1,2-thiazine derivatives in neuroinflammation induced by preincubation with lipopolysaccharide or coculturing with microglia-like cells
BackgroundAlzheimer’s disease (AD) is considered the most common cause of dementia among the elderly. One of the modifiable causes of AD is...
-
The application of in silico experimental model in the assessment of ciprofloxacin and levofloxacin interaction with main SARS-CoV-2 targets: S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase and papain-like protease (PLpro)—preliminary molecular docking analysis
BackgroundThe new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified at the end of 2019. Despite growing understanding of...
-
Therapeutic Proteins and Advanced Therapy Medicinal Products
This chapter is divided in two parts: Therapeutic proteins and Advanced Therapy Medicinal Products (ATMPs)....