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Synthesis and Investigation of Carbonic Anhydrase I and II Activity of Dihydrobenzo[h]Quinazolin-2-yl Thiourea Compounds
Thirteen novel compounds in a series of dihydrobenzo[ h ]quinazolin-2-yl thiourea compounds ( 7a–m ) were synthesized and characterized using FT-IR, 1 H, 13 ...
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Spiroxatrine derivatives towards 5-HT1A receptor selectivity
BackgroundIn our previous work, spiroxatrine was taken as reference compound to develop selective NOP ligands. Therefore, several triazaspirodecanone...
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Anthraquinone and Naphthoquinone Derivatives from the Pericarps of Juglans sigillata
Four new anthraquinones ( 1–4 ), along with four known ones ( 5–8 ) and five known naphthoquinones ( 9–13 ), were isolated from the green pericarps of...
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A New Isoflavone Triglycoside from Green Husks of Juglans sigillata
Phytochemical investigation of the n -BuOH fraction of the 70% EtOH extract of Juglans sigillata green husks afforded a new isoflavone triglycoside,...
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Synthesis of Spinochrome D, A Metabolite of Various Sea-Urchin Species
The sea-urchin metabolite spinochrome D ( 1 ) was synthesized in 58% overall yield via oxidation of 2,3-dichloronaphthazarin ( 13 ) into...
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Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin
Background5,5-Diphenylhydantoin (Phenytoin) is a well-known anticonvulsant and antiarrhythmic drug which may cause unwanted side effects. In order to...
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Chemical constituents from the leaves of Juglans mandshurica
Two new ( 1 and 3 ) and two known diarylheptanoids ( 2 and 4 ), along with two tetralones ( 5 and 6) , one naphthoquinone ( 7 ), four phenylpropanoids ( 8 – 11 ),...
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Phytochemicals and antimicrobial potentials of mahogany family
Drug resistance to human infectious diseases caused by pathogens lead to premature deaths through out the world. Plants are sources for wide variety...
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Pharmacotherapy of Pathological States of Adrenal Glands (Review)
Recent advances in the pharmacological treatment of hormonal hyperfunction and insufficiency of adrenal glands were reviewed.
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Chemical Constituents from Aphanamixis grandifolia
One new sterol, (3 β ,21 α ,22a)-stigmast-5-ene-3,21,22-triol ( 1 ), together with 36 compounds ( 2 – 37 ), were isolated from the stems of Aphanamixis...
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Synthesis and Antimicrobial and Antifungal Activity of Carbamate-Functionized Spiro Compounds
A series of carbamate-functionalized spiro compounds were synthesized by [3+2]-cycloaddition and condensation reactions based on methyl...
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Metabolites from the mangrove-derived fungus Xylaria cubensis PSU-MA34
Two new succinic acid derivatives, xylacinic acids A ( 1 ) and B ( 2 ), along with seven known compounds, including one succinic acid derivative ( 3 ),...
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Two new acorane sesquiterpenes from Illicium henryi
Two new acorane sesquiterpenes, 10-hydroxyacoronene ( 1 ) and 1β-isopropyl-4β-methyl-9β-hydroxy spiro[4.5]dec-6-en-8-one ( 2 ), one new natural product,...
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Total synthesis of miltirone
A concise synthesis of miltirone from 6-isopropyl-7-methoxy-1-tetralone is described, in which the naphthol was oxidized with Dess-Martin periodinane...
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Natural arylterpenes and their biological activity
Information on naturally occurring aromatic mono-, sesqui-, and diterpenes was systematized. The types of their biological activity and possible...
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Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors
Although the adrenergic receptors have been cloned since the late 1980s and early 1990s, analysis of the expression of the subtypes in specific...