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Chemical Composition of the Essential Oil of Euphorbia guyoniana Boiss. et Reut.
To our knowledge, this study represents the first investigation into the chemical composition of the essential oil of Euphorbia guyoniana Boiss. et...
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From Relative to Absolute Stereochemistry of Secondary Metabolites: Applications in Plant Chemistry
Structural elucidation of specialized metabolites or natural plant products, especially the stereochemical features of chiral bioactive metabolites,...
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Quality Requirements and Analysis
For the control of the production of medicines quality requirements are essential. Quality requirements cover the quality of the preparation...
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A New Diarylheptanoid from the Twigs of Quercus Acutissima and their Neuroprotective Activity
A new diarylheptanoid glycoside, acutissioside A ( 4 ), along with five known diarylheptanoids ( 1–3 , 5 , 6 ) was isolated from the twigs of Quercus...
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Structure Elucidation of a Methylated Flavan-3-ol and Dimeric Prodelphinidin from Stryphnodendron adstringens
The new methylated polyphenols, 4’- O -methyl- ent -epigallocatechin and 4’- O -methyl-epigallocatechin-3- O -gallate-(4 α → 8)-gallocatechin, together with...
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Interaction of Copper(II) Ions with Pectin in Solutions
The search for new detoxifiers that effectively bind toxic metals and retain vital metals in the human body is currently an urgent problem in...
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Post-Alcohol Corn Dregs as a Pharmaceutical Source for Obtaining Nitrogen-Containing Betaines
A method was developed for producing betaine hydrochlorides (with added pepsin) in the form of substances and tablets intended for use as drugs with...
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Stereospecificity of the Cytoprotective and Antidepressant-Like Activities of GTS-301, a Dimeric Dipeptide Mimetic of Neurotrophin-3
A dimeric dipeptide mimetic based on the β-turn of the 4 th loop of neurotrophin-3, bis-( N -monosuccinyl- L -asparaginyl- L -asparagine)hexamethylenediamide...
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New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1)
Phenalenone derivatives sourced from fungi are polyketides that have attracted significant interest because of their diverse chemical structures and...
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Synthesis of Chalcone Derivative from Clove Leaf Waste as a Natural Antioxidant
The synthesis of chalcone derivatives from clove leaf waste and their potential application as natural antioxidants have been studied. Synthesis of...
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New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Gymnopilus orientispectabilis , also known as “big laughter mushroom,” is a hallucinogenic poisonous mushroom that causes excessive laughter upon...
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2-Geranyl-1-methoxyerythrabyssin II alleviates lipid accumulation and inflammation in hepatocytes through AMPK activation and AKT inhibition
A growing proportion of the global adult and pediatric populations are currently affected by nonalcoholic steatohepatitis (NASH), leading to rising...
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Development of Technology and Equipment for Enisamium Iodide Drying
A methodological approach to selecting the optimal drying method for enisamium iodide, an antiviral agent with a broad spectrum of pharmacological...
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Triticum aestivum Octacosanol, a Potential Inhibitor of PCSK9 in Fat Diet–Induced Hypercholesteromia
Proprotein convertase subtilisin-like kexin type 9 (PCSK9) is a circulating serine protease that promotes the degradation of low-density lipoprotein...
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Design and Synthesis of Dipeptide Nerve Growth Factor Loop 1 Mimetics and In Vitro Studies of their Neuroprotective and Differentiation-Inducing Activities
Previous studies at the V. V. Zakusov Science Research Institute of Pharmacology created a dimeric dipeptide mimetic of the most exposed fourth loop...
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Dipeptide Ligands of TSPO
Our own investigations of the synthesis and pharmacological properties of dipeptide ligands of the translocator protein (TSPO) are reviewed. The...
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Phytochemical and pharmacological properties of Myristica fragrans Houtt.: an updated review
Myristica fragrans Houtt. (Myristicaceae), an aromatic evergreen tree, is well known as a commercial source of mace (aril) and nutmeg (seed), which...
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Vibrational Circular Dichroism for the Assignment of Absolute Configuration of Natural Products in Brazil
AbstractThe determination of the absolute configuration of chiral bioactive natural products is a crucial step in their structural characterization....
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Anti-neuroinflammatory effect of oxaline, isorhodoptilometrin, and 5-hydroxy-7-(2′-hydroxypropyl)-2-methyl-chromone obtained from the marine fungal strain Penicillium oxalicum CLC-MF05
Penicillium is a rich source of bioactive compounds. Among all Penicillium species, Penicillium oxalicum has been reported to produce various types...
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Structures, biomimetic synthesis, and anti-SARS-CoV-2 activity of two pairs of enantiomeric phenylpropanoid-conjugated protoberberine alkaloids from the rhizomes of Corydalis decumbens
(±)-Decumicorine A ( 1 ) and (±)- epi -decumicorine A ( 2 ), two pairs of enantiomeric isoquinoline alkaloids featuring a novel phenylpropanoid-conjugated...
