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Volatile Oil from Magnolia sieboldii Improve Neurotransmitter Disturbance and Enhance the Sleep-Promoting Effect in p-Chlorophenylalanine-Induced Sleep-Deprived Mice
Sleep-promoting effects of Magnolia sieboldii K.Koch, Magnoliaceae, volatile oils and elucidate their potential mechanisms in Kunming mice with p -chlo...
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Modulating role of serotonergic signaling in sleep and memory
Serotonin is an important neurotransmitter with various receptors and wide-range effects on physiological processes and cognitive functions including...
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The association of the quality of sleep with proinflammatory cytokine profile in inflammatory bowel disease patients
BackgroundThe role of circadian rhythm abnormalities in patients with inflammatory bowel disease (IBD) remains relatively unknown. The aim of this...
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Sleep improvement is associated with the antidepressant efficacy of repeated-dose ketamine and serum BDNF levels: a post-hoc analysis
RationaleRecently, the effects of ketamine on the circadian rhythm have suggested that ketamine’s rapid antidepressant effects are associated with...
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An Innovative Stress-Protective and Detoxification Substance for Reducing the Central Nervous System Effects of Alcohol Intoxication
The search for new drugs to reduce the toxic effects of alcohol on the body is based on the creation of various pharmaceutical agents that affect the...
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Insulin resistance, clinical presentation and resistance to selective serotonin and noradrenaline reuptake inhibitors in major depressive disorder
BackgroundThe understanding of mechanisms underlying non-response to antidepressants is limited. The latest data highlights the role of insulin...
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The effect of alpha lipoic acid on passive avoidance and social interaction memory, pain perception, and locomotor activity in REM sleep-deprived rats
BackgroundEvidence shows the vital role of sleep in the modulation of cognitive functions. Sleep deprivation (SD) can disrupt learning and memory...
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Consider fibromyalgia in older patients with chronic widespread pain
Fibromyalgia (FM) is a chronic condition involving widespread pain and usually fatigue and/or sleep problems. It can significantly decrease patients’...
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Fezolinetant in the treatment of vasomotor symptoms associated with menopause: a profile of its use
Fezolinetant (VEOZAH ™ ; Veoza ™ ), a first-in-class neurokinin 3 receptor (NK3R) antagonist, represents a promising novel non-hormonal treatment option...
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Voltage-clamp evidence of GABAA receptor subunit-specific effects: pharmacodynamic fingerprint of chlornordiazepam, the major active metabolite of mexazolam, as compared to alprazolam, bromazepam, and zolpidem
BackgroundAnxiolytic benzodiazepines, due to their clinical effectiveness, are one of the most prescribed drugs worldwide, despite being associated...
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Pharmacological management of psychoactive substance withdrawal syndrome
RationaleMedications are available to manage alcohol and drug withdrawal, but they are underutilized. Only a handful, such as methadone,...
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The treatment of post-traumatic nightmares requires more attention
Nightmares are common and persistent in post-traumatic stress disorder (PTSD). These post-traumatic nightmares (PTNs) are resistant to general PTSD...
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Long-term topical corticosteroid treatment for atopic dermatitis: an in-depth analysis of safety, efficacy, withdrawal, and patient experiences
Atopic dermatitis, often referred to as eczema, is classified as a chronic inflammatory skin disorder with increasing prevalence. Topical...
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Lemborexant in insomnia disorder: a profile of its use
Lemborexant (Dayvigo™), a dual orexin receptor antagonist, is an effective and well-tolerated treatment option for adults with insomnia characterized...
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Can research on entactogens contribute to a deeper understanding of human sexuality?
In recent years, scientific research into the therapeutic potential of psychedelic compounds has experienced a resurgence of interest. New studies...
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Biopharmaceutics
Biopharmaceutics, in connection with pharmacokinetics, is the field that investigates and describes everything that happens with a medicinal product...
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Self-Therapy
Most of our genetically defined disease risks will involve so many genes that it will be unrealistic to erase them from our body by gene therapy....
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Amantadine extended release capsules (GOCOVRI®) in Parkinson’s disease: a profile of its use in the USA
Amantadine extended release (ER) [GOCOVRI ® ], an NMDA receptor antagonist, is an important treatment option in the management of levodopa-induced...
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Evaluation of effects of chronic nasal steroid use on rhinological symptoms of COVID-19 with SNOT-22 questionnaire
BackgroundThe benefits of corticosteroids for the treatment of COVID-19 infection are documented in the literature. The goal of the study is to...
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Recent advances in the pathology of prodromal non-motor symptoms olfactory deficit and depression in Parkinson’s disease: clues to early diagnosis and effective treatment
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by movement dysfunction due to selective degeneration of...
