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Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a theoretical perspective
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes pulmonary injury or multiple-organ injury by various pathological...
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A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome
BackgroundWe designed this single-centre clinical trial to assess the potential benefits of N -Acetylcysteine (NAC) in patients with...
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Health-related quality of life in survivors of severe COVID-19 infection
BackgroundLong-term effects of Coronavirus Disease 2019 (COVID-19) are increasingly recognized as having a significant impact on Health-Related...
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Neurological consequences of COVID-19
In December 2019, cases of pneumonia caused by infection with the previously unknown severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),...
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Therapy for HIV-associated cryptococcal meningitis: a case report demonstrating a new treatment approach emphasizing updated treatment guidelines
Cryptococcal meningitis (CM) remains a significant global health burden, especially for persons living with HIV. Despite effective antiretroviral and...
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Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century’s plague accounting for...
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Isoacteoside Protects Against Sepsis-Induced Acute Lung Injury by Regulating the SIRT1/Nrf2/NF-κB/NLRP3 Signaling Pathways
Sepsis-related acute lung injury is a severe inflammatory pulmonary disorder. Isoacteoside is a phenylethanoid derived from Monochasma savatieri ...
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Severe prolonged neutropenia following administration of tocilizumab in a patient affected by COVID-19: a case report and brief review of the literature
Tocilizumab is one of the newest therapeutic options for the acute respiratory distress syndrome (ARDS) caused by the recently discovered severe...
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Paritaprevir ameliorates experimental acute lung injury in vitro and in vivo
Paritaprevir is a potent inhibitor of the NS3/4A protease used to treat chronic hepatitis C virus infection. However, its therapeutic effect on acute...
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Nirmatrelvir plus ritonavir in COVID-19: a profile of its use
Oral nirmatrelvir plus ritonavir (Paxlovid ™ ) is an effective treatment option for coronavirus disease 2019 (COVID-19), the illness caused by severe...
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Safflor Yellow A Protects Beas-2B Cells Against LPS-Induced Injury via Activating Nrf2
Acute lung injury and its severe form acute respiratory distress syndrome are lethal lung diseases. So far, effective therapy for the diseases is...
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Curine Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Downregulating the TLR4/MD-2/NF-κB(p65) Signaling Pathway
Acute lung injury is characterized by alveolar-capillary barrier rupture, neutrophil-mediated airway inflammation, and tissue hypoxia. Since no...
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The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemic
The unprecedented pandemic of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which leads to COVID-19, is threatening global health....
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Pharmacological management of psychoactive substance withdrawal syndrome
RationaleMedications are available to manage alcohol and drug withdrawal, but they are underutilized. Only a handful, such as methadone,...
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The effect of tocilizumab on cytokine release syndrome in COVID-19 patients
BackgroundThis study was aimed to assess the efficacy and safety of tocilizumab (TCZ) and to investigate the factors related to the progress and...
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COVID-19: State of the Vaccination
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting coronavirus disease 2019 (COVID-19) pandemic has...
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RNA Delivery to Mitochondria
The approval of mRNA-containing lipid nanoparticles (LNPs) for use in a vaccine against the severe acute respiratory syndrome coronavirus 2...
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Medicinal Plants in Peru as a Source of Immunomodulatory Drugs Potentially Useful Against COVID-19
The current COVID-19 pandemic, characterized by a highly contagious severe acute respiratory syndrome, led us to look for medicinal plants as an...
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Recent review of COVID-19 management: diagnosis, treatment and vaccination
The idiopathic Coronavirus disease 2019 (COVID-19) pandemic outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has...
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Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis
Anecdotal evidence suggests that the severity of coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2...
