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Rearrangement of Epoxide Derivatives Semisynthesized from β-Himachalene using Lewis and Bronsted Acids Catalysis
The acid-catalyzed rearrangement of epoxides 3a , 4a , 6a , and 7a derived from β-himachalene, the major constituent of Cedrus atlantica essential oil,...
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Synthesis and pharmacological evaluation of novel cis and trans 3-substituted anilidopiperidines
Background4-Anilidopiperidine class of synthetic opioid analgesics, with it’s representative fentanyl, are by far the most potent and clinically...
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Study of the Pressing Process of N-Butyl-N-Methyl-1-Phenylpyrrolo-[1,2-a]Pyrazine-3-Carboxamide (GML-3) Tablets Using Mathematical Modeling Techniques
N -Butyl- N -methyl-1-phenylpyrrolo[1,2- a ]pyrazine-3-carboxamide (GML-3) is an original molecule developed at the Research Zakusov Institute of...
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Oral Dispersible Tablets of GK-2 [bis-(N-Monosuccinyl-L-Glutamyl-L-Lysine) Hexamethyleneamide]: Optimization of Pressing Process by Mathematical Modeling Based on the Heckel and Kawakita Equations
Optimization of the tablet pressing process is currently an urgent task in the pharmaceutical industry because this technological stage largely...
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Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine
Indazole-based HDAC6 inhibitors with novel zinc-binding modifications were synthesized and evaluated to determine their potential to inhibit HDAC6....
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Sclareol: Isolation, Structural Modification, Biosynthesis, and Pharmacological Evaluation – A Review
Sclareol, isolated from a variety of plant species like Salvia sclarea , is a labdane diterpene of high value for the flavour and fragrance...
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Multi-Step Rearrangement Mechanism for Acetyl Cedrene to the Hydrocarbon Follower†
Conversion of acetyl cedrene ( 2 ) to its follower ( 3 ) using acetic anhydride and polyphosphoric acid involves a multi-step cationic molecular...
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Characterization of Drug Delivery Systems by Transmission Electron Microscopy
The contribution of electron microscopy, and here, in particular transmission electron microscopy (TEM), to the formulation and understanding of the...
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Gαi-derived peptide binds the µ-opioid receptor
BackgroundG protein-coupled receptors (GPCRs) transduce external stimuli into the cell by G proteins via an allosteric mechanism. Agonist binding to...
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ROCK Kinase Inhibitory Activity of Some Isoflavonoids and Their Pharmacological Significance in Glaucoma
Glaucoma is a chronic inflammatory disorder characterized by the loss of optic nerve fibers and the formation of retinopathy. The redox homeostasis...
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Synthesis and Cytotoxicity of A-Azepanodammaradiene
Sequential transformations of dipterocarpol (oximation, first-order Beckmann rearrangement, dehydration, isomerization) synthesized the new...
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Chloroacetates of Substituted 1H-Indol-5-,6-,7-Ylamines and Their Antimicrobial Activity
Water-soluble 1 H -indol-5-, 6-, 7-ylammonium chloroacetates were obtained from the reaction of substituted 1 H -indol-5-, 6-, 7-ylamines with...
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Protective Effects of Paeoniflorin Against Inflammation and Oxidative Stress in Rats with Gestational Diabetes Mellitus via Inhibiting the RhoA/ROCK Signaling Pathway
Gestational diabetes mellitus is a condition of glucose intolerance that occurs only in pregnant women. Paeoniflorin was reported to possess...
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Adaptogenic Activity of Flavonoids Isolated from the Aerial Part of Scutellaria comosa
Five series of samples of the substance containing total flavonoids were obtained from the aerial part of Scutellaria comosa Juz. The characteristics...
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Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form
The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro . The conditions of the...
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Rhythm-Modulating Activity of Fractions of Aqueous Extract of Agrimonia pilosa
Individual fractions containing significant quantities of lithium were obtained from an aqueous extract of Agrimonia pilosa ; tannin fractions showed...
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Synthesis, Structure, and Cytotoxic Activities of a Novel Lactam of the Diterpenoid Isosteviol
A novel compound lactam of 15 β -hydroxymethylisosteviol ethyl ester 3 has been synthesized and structurally characterized by IR, NMR, and HR-MS. Its...
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Soluble dipeptidyl peptidase-4 induces epithelial–mesenchymal transition through tumor growth factor-β receptor
BackgroundKidney fibrosis is the final manifestation of chronic kidney disease, a condition mainly caused by diabetic nephropathy. Persistent tissue...
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Isolation, structure elucidation, total synthesis, and biosynthesis of dermazolium A, an antibacterial imidazolium metabolite of a vaginal bacterium Dermabacter vaginalis
Dermabacter vaginalis is a human-derived bacterium isolated from vaginal fluid of a Korean female in 2016. Although several human-related species in Dermabacter...
