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Psoralen Ameliorates Acetaminophen-Induced Acute Liver Injury by Inhibiting the Enzymatic Activity of CYP2E1
Excessive administration of the antipyretic and analgesic drug acetaminophen can cause acute liver injury. The mechanism is that a large amount of N -acetyl-...
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A Validated HPLC Method for the Simultaneous Quantification of Curcumin, Silybin, and Psoralen: Application to Phytopharmaceuticals
The present study was aimed to develop a simple, sensitive, and precise reversed-phase HPLC method for the simultaneous separation and quantification...
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Pharmacokinetic-Pharmacodynamic Characterization of a Topical Photochemotherapy Using Brosimum gaudichaudii in C56BL/6 Mice
Photochemotherapy or ultraviolet radiating treatment is widely used in the treatment of vitiligo via oral dosages that often resulted in high...
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Melanogenic Effect and Toxicity Assessments of Standardized Extract of Brosimum gaudichaudii
Brosimum gaudichaudii Trécul, Moraceae, is a Brazilian plant species used in traditional medicine to treat vitiligo or as an additive in natural...
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Pharmacokinetics and Oral Bioavailability of Coumarins and Carbazole Alkaloids from Clausena harmandiana Root Bark in Rats
The root bark of Clausena harmandiana Pierre ex Guillaumin, Rutaceae, has been widely studied for its antimalarial activity, action against cancer...
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Modified Coumarins. 41. Synthesis of Substituted 6-Thiazolylpsoralens
Psoralen structural analogs containing 6-(1,3-thiazolyl-4-yl) substituents on furo[3,2-g]chromen-7-one systems were synthesized using the Macleod...
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Manage vitiligo with a personalised approach: consider old and new treatments
Vitiligo is an autoimmune condition that causes loss of skin colour. For many years it has been managed using treatments that simply dampen immune...
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New tricyclic systems as photosensitizers towards triple negative breast cancer cells
Nineteen pyrrolo[1,2- h ][1,7]naphthyridinones and pyrido[2,3- c ]pyrrolo[1,2- a ]azepinones were synthesized as new tricyclic systems in which the...
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Development of a Liposomal form of Furanocoumarins and Evaluation of its Antitumor Efficacy
A method for obtaining a liposomal form of furanocoumarins from Sosnowsky’s hogweed (SH) is proposed. Furanocoumarins were isolated from SH juice...
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Two 1,2-Seco-Coumarins from Clausena lansium
A new 1,2-seco-furan-coumarin, claulancoumarin A ( 1 ), and a known 1,2-seco-coumarin, (Z)-2,4-dihydroxycinnamic acid ( 2 ), were isolated from the...
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A New Dihydrocoumarin from Ficus sycomorus
A phytochemical study of the fruits and leaves of Ficus sycomorus L. led to the isolation of a new dihydrocoumarin,...
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BIOSYNTHESIS OF PLANT SUBSTANCES; BIOGENETIC RELATIONSHIPS
The bioactive substances in medicinal plants will be discussed on the basis of their chemical structure, or more precisely, of a...
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Xanthotoxin reverses Parkinson’s disease-like symptoms in zebrafish larvae and mice models: a comparative study
BackgroundThe aim of this study is to preliminary evaluate the antiparkinsonian activity of furanocoumarin—xanthotoxin, in two behavioral animal...
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Validation of a photostability indicating method for quantification of furanocoumarins from Brosimum gaudichaudii soft extract
A validation study of a reverse-phase high-performance liquid chromatographic assay for the quantification of two furanocoumarins (psoralen and...
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Medicinal Angiosperms of Papilionaceae (Cont. III)
This chapter introduces 29 species of medicinal plants in 1 family, mainly including Pterocarpus indicus, Pueraria lobate, Pueraria lobata var....
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Ozanimod in relapsing forms of multiple sclerosis: a profile of its use
Ozanimod (Zeposia ® ), a sphingosine 1-phosphate (S1P) receptor modulator with high selectivity for S1P receptor subtypes 1 and 5 (S1P 1 and S1P 5 ),...
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Microbiology
Microbial contamination of pharmaceutical preparations may cause a health hazard to the patient (e.g. infection, pyrogenic or allergic reaction),...
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Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by a burning sensation and eczematous lesions...
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DISCUSSION OF HERBAL DRUGS BASED ON THE BIOGENETIC CLASSIFICATION OF THEIR MAIN ACTIVE COMPONENTS
Honey is prepared by honey-bees (Apis mellifera) from the nectar and honeydew of flowers. After chemical conversion by the gastric juices in the...