Search
Search Results
-
Unraveling snake venom phospholipase A2: an overview of its structure, pharmacology, and inhibitors
Snake bite is a neglected disease that affects millions of people worldwide. WHO reported approximately 5 million people are bitten by various...
-
ROCK Kinase Inhibitory Activity of Some Isoflavonoids and Their Pharmacological Significance in Glaucoma
Glaucoma is a chronic inflammatory disorder characterized by the loss of optic nerve fibers and the formation of retinopathy. The redox homeostasis...
-
Interactions between metabotropic glutamate and CB1 receptors: implications for mood, cognition, and synaptic signaling based on data from mGluR and CB1R-targeting drugs
Metabotropic glutamate receptors (mGluRs) are part of the G protein-coupled receptors (GPCRs) family. They are coupled to G αq (group I) or G i/o ...
-
Effect of Diclofenac Sodium and its Combinations with Mexidol on Fe2+-Induced Chemiluminescence
The effect of diclofenac sodium, Mexidol, and their combination on Fe 2+ -induced chemiluminescence was studied in vitro . Diclofenac sodium in the...
-
Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy
Natural compounds originating from plants offer a wide range of pharmacological potential and have traditionally been used to treat a wide range of...
-
Therapeutic implication of Sonic Hedgehog as a potential modulator in ischemic injury
Sonic Hedgehog (SHh) is a homology protein that is involved in the modeling and development of embryonic tissues. As SHh plays both protective and...
-
Aldose Reductase: a cause and a potential target for the treatment of diabetic complications
Diabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the blood. In this hyperglycaemic condition, aldose...
-
Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a theoretical perspective
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes pulmonary injury or multiple-organ injury by various pathological...
-
Signaling pathways underlying changes in the contractility of the stomach fundus smooth muscle in diabetic rats
Dysfunction of gastrointestinal (GI) motility is a common complication in patients with diabetes mellitus (DM). Studies related to changes in fundus...
-
A Molecular Insight into Significance of Functional Foods in Better Management of Rheumatoid Arthritis
Rheumatoid arthritis is a systemic, autoimmune disorder of complex etiology, characterized by chronic inflammation of joints with severe pain and...
-
Ameliorating effects of berberine on sepsis-associated lung inflammation induced by lipopolysaccharide: molecular mechanisms and preclinical evidence
As a life-threatening disorder, sepsis-associated lung injury is a dysregulated inflammatory response to microbial infection, characterized by the...
-
Manage endodontic pain with a combination of analgesics, including non-steroidal anti-inflammatory drugs
Endodontic pain often presents as a dental emergency as apprehensive patients defer what they anticipate as a painful experience. Most correctly...
-
Glucose-6-Phosphatase and α-Glucosidase Inhibitors from Smilax moranensis Roots Identified by Affinity-Directed Fractionation
The ethanol/water-soluble extracts of the roots of Smilax moranensis M. Martens & Galeotti, Smilacaceae, which have been appreciated since...
-
Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review
Over the last several decades, the percentage of patients suffering from different forms of arthritis has increased due to the ageing population and...
-
Retinoic acid attenuates nuclear factor kappaB mediated induction of NLRP3 inflammasome
BackgroundAcetylcholine (ACh), a neurotransmitter and a part of the cholinergic system, can modify immune responses. Expression of acetylcholine...
-
In Vitro Evaluation of Antioxidant, Antimicrobial, Cytotoxic, Anti-Inflammatory, Anti-Aging, Enzyme Inhibition Potential, and HPLC Analysis of Traditionally Used Plant Delphinium Uncinatum Wall
Delphinium uncinatum Wall. (Ranunculaceae) is a native medicinal plant found on the sub-continent that is utilized to cure various human diseases....
-
Agonisten und Antagonisten von membranständigen Rezeptoren
Die Versendung und Weiterleitung von Informationen zwischen Zellen wird von Botenstoffen übernommen. Diese können so klein sein wie einzelne Ionen,...
-
Galangin, as a Potential Anticancer Agent
Cancer is a major global health issue and one of the main causes of mortality worldwide. In recent years, cancer mortality and morbidity rates have...
-
Anti-diabetic Effect of Major Compounds from Commelina diffusa
Although Commelina diffusa Burm.f., Commelinaceae, has been proven to exhibit many pharmacological activities, the scientific evidence for its...
-
Role of Natural Flavonoid Products in Managing Osteoarthritis
Flavonoids belong to a subgroup of polyphenol bioactive compounds of plant origin. They are a topic of interest for their anti-inflammatory and...
