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Unraveling snake venom phospholipase A2: an overview of its structure, pharmacology, and inhibitors
Snake bite is a neglected disease that affects millions of people worldwide. WHO reported approximately 5 million people are bitten by various...
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ROCK Kinase Inhibitory Activity of Some Isoflavonoids and Their Pharmacological Significance in Glaucoma
Glaucoma is a chronic inflammatory disorder characterized by the loss of optic nerve fibers and the formation of retinopathy. The redox homeostasis...
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Plasma lipid profile: a predictive marker of disease severity among COVID-19 patients—an opportunity for low-income countries
ObjectiveThis study aimed to assess the correlation between body mass index (BMI) and plasma lipid profile levels in mild and severe COVID-19...
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Aldose Reductase: a cause and a potential target for the treatment of diabetic complications
Diabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the blood. In this hyperglycaemic condition, aldose...
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Rosmarinus officinalis Volatile Oil Nanogel Modulated Muscle Damage Induced by Bothrops moojeni Venom: a Phonophoresis Method
Bothrops moojeni venom contains toxins that induce local toxic effects, leading to a severe inflammatory process, pain, hemorrhage, edema, and...
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Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy
Natural compounds originating from plants offer a wide range of pharmacological potential and have traditionally been used to treat a wide range of...
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Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
Women are significantly more likely to develop depression than men. Fluctuations in the ovarian estrogen hormone levels are closely linked with...
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Manage endodontic pain with a combination of analgesics, including non-steroidal anti-inflammatory drugs
Endodontic pain often presents as a dental emergency as apprehensive patients defer what they anticipate as a painful experience. Most correctly...
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Galangin, as a Potential Anticancer Agent
Cancer is a major global health issue and one of the main causes of mortality worldwide. In recent years, cancer mortality and morbidity rates have...
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Effect of Diclofenac Sodium and its Combinations with Mexidol on Fe2+-Induced Chemiluminescence
The effect of diclofenac sodium, Mexidol, and their combination on Fe 2+ -induced chemiluminescence was studied in vitro . Diclofenac sodium in the...
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Alcoholic liver disease: a new insight into the pathogenesis of liver disease
Excessive alcohol consumption contributes to a broad clinical spectrum of liver diseases, from simple steatosis to end-stage hepatocellular...
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Interactions between metabotropic glutamate and CB1 receptors: implications for mood, cognition, and synaptic signaling based on data from mGluR and CB1R-targeting drugs
Metabotropic glutamate receptors (mGluRs) are part of the G protein-coupled receptors (GPCRs) family. They are coupled to G αq (group I) or G i/o ...
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A Molecular Insight into Significance of Functional Foods in Better Management of Rheumatoid Arthritis
Rheumatoid arthritis is a systemic, autoimmune disorder of complex etiology, characterized by chronic inflammation of joints with severe pain and...
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Therapeutic implication of Sonic Hedgehog as a potential modulator in ischemic injury
Sonic Hedgehog (SHh) is a homology protein that is involved in the modeling and development of embryonic tissues. As SHh plays both protective and...
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Neuroprotective and Neuroregenerative Properties of Dimeric Dipeptide Mimetics of Individual NGF and BDNF Loops Under Conditions of an Experimental Ischemic Stroke Model
This article reviews our work devoted to studying the biochemical properties of original dimeric dipeptide mimetics of nerve growth factor (NGF) and...
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Psychedelics action and schizophrenia
Psychedelics are compounds acting by serotonin 5-hydroxytryptamine (5-HT) 2A receptor activation and induce several behavioral responses. They are of...
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Revisiting Ipriflavone: a Potential Isoflavone for the Management of Postmenopausal Osteoporosis
Ipriflavone is a nutraceutical extensively used in Asian countries since 1890 for postmenopausal osteoporosis as a phytoestrogen to inhibit bone...
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Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review
Over the last several decades, the percentage of patients suffering from different forms of arthritis has increased due to the ageing population and...
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Signaling pathways underlying changes in the contractility of the stomach fundus smooth muscle in diabetic rats
Dysfunction of gastrointestinal (GI) motility is a common complication in patients with diabetes mellitus (DM). Studies related to changes in fundus...
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In Vitro Evaluation of Antioxidant, Antimicrobial, Cytotoxic, Anti-Inflammatory, Anti-Aging, Enzyme Inhibition Potential, and HPLC Analysis of Traditionally Used Plant Delphinium Uncinatum Wall
Delphinium uncinatum Wall. (Ranunculaceae) is a native medicinal plant found on the sub-continent that is utilized to cure various human diseases....
