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A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice
BackgroundIA-0130 is a derivative of 3-(1,3-diarylallylidene)oxindoles, which is a selective estrogen receptor modulator (SERM). A previous study...
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Medicinal Plants in Peru as a Source of Immunomodulatory Drugs Potentially Useful Against COVID-19
The current COVID-19 pandemic, characterized by a highly contagious severe acute respiratory syndrome, led us to look for medicinal plants as an...
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Recent progress in biologically active indole hybrids: a mini review
The indole moiety is one of the most widespread heterocycles found in both natural products and biological systems. Indoles have important biological...
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Challenges and opportunities of develo** small-molecule therapies for age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of vision loss in senior adults. The disease can be categorized into two types: wet AMD...
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Synthesis of novel spirooxindole-pyrrolidines and evaluation of their cytotoxic activity
BackgroundA variety of spirooxindoles have demonstrated cytotoxic activity toward several cancer cell lines. This study investigates the cytotoxicity...
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Bioactive natural products from the genus Salinospora: a review
Actinomycetes are an important source for bioactive secondary metabolites. Among them, the genus Salinispora is one of the first salt obligatory...
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DISCUSSION OF HERBAL DRUGS BASED ON THE BIOGENETIC CLASSIFICATION OF THEIR MAIN ACTIVE COMPONENTS
Honey is prepared by honey-bees (Apis mellifera) from the nectar and honeydew of flowers. After chemical conversion by the gastric juices in the...
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Current Strategies in Development of New Chromone Derivatives with Diversified Pharmacological Activities: A Review
Chromone derivatives possess a spectrum of biological activities. Chromone has been recognized as a privileged structure for new drug invention and...
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Monoterpenoid Indole Alkaloids from the Leaves of Alstonia scholaris
A chemical investigation on the ethanol extract from the leaves of Alstonia scholaris led to the isolation of two new monoterpenoid indole alkaloids,...
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Thiadiazole derivatives as anticancer agents
In spite of substantial progress made toward understanding cancer pathogenesis, this disease remains one of the leading causes of mortality. Thus,...
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Protein Glycation During Diabetes Mellitus and the Possibility of its Pharmacological Correction (Review)
Non-enzymatic interaction of reducing sugars with free amines of proteins (Maillard reaction) leads to the formation of advanced glycation end...
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Toxicity and antinociceptive effects of Hamelia patens
Many medicinal herbs are used in folk medicine without taking into account their toxicity. Hamelia patens Jacq. (Rubiaceae), a Mexican endemic...
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The catechol-O-methyltransferase inhibitory potential of Z-vallesiachotamine by in silico and in vitro approaches
Z -Vallesiachotamine is a monoterpene indole alkaloid that has a β- N -acrylate group in its structure. This class of compounds has already been...
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In vitro and in vivo antifungal activity, liver profile test, and mutagenic activity of five plants used in traditional Mexican medicine
Berberis hartwegii Benth ., Berberidaceae, Hameliapatens Jacq.,Rubiaceae, Dendropanaxarboreus (L.)Decne & Planch., Araliaceae, Erythrina herbacea L.,...
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Marine organisms as source of extracts to disrupt bacterial communication: bioguided isolation and identification of quorum sensing inhibitors from Ircinia felix
tIn this study, 39 extracts from marine organisms were evaluated as quorum sensing inhibitors, collected in the Colombian Caribbean Sea and the...
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Asymmetric synthesis and evaluation of α-quaternary chiral lactam derivatives as novel anticancer agents
Asymmetric synthesis of α-quaternary chiral lactam derivatives as novel anticancer agents and evaluation of their cytotoxic potentials and spectrums...
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Biochemical and pharmacological characterization of isatin and its derivatives: from structure to activity
Isatin, k1H-indole-2,3-dione, kis a heterocyclic compound of significant importance in medicinal chemistry. It is a synthetically versatile molecule,...
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Synthesis, screening and antimicrobial activity evaluation of spiro indolothiazolidinone, oxazolidinone and azetidene derivatives of benzenesulfonyl chloride
In an attempt to find a new class of antimicrobial agents, a series of indolothiazolidinone, oxazolidinone, and azetidene analogs of benzenesulfonyl...
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New 8-aminoalkyl derivatives of purine-2,6-dione with arylalkyl, allyl or propynyl substituents in position 7, their 5-HT1A, 5-HT2A, and 5-HT7 receptor affinity and pharmacological evaluation
BackgroundOur previous studies in a group of arylpiperazine derivatives of 1,3-dimethyl-3,7-dihydro-purine-2,6-diones, aimed at chemical...
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Synthesis of novel isatin-thiazoline and isatin-benzimidazole conjugates as anti-breast cancer agents
A series of new isatin-thiazoline 3a–h and isatin-benzimidazole 4a–h derivatives were synthesized via condensation of isatin Mannich bases 2a–h with...