Search
Search Results
-
Real-World Evidence to Support the Registration of a New Osteoporosis Medicinal Product in Europe
Real-World Evidence (RWE), which has historically been used to support post-approval safety studies, has recently gained acceptance for new drug...
-
Effect of Ellipticine in Glucocorticoid-Induced Osteoporosis: In Silico and In Vivo Analyses
Glucocorticoids cause secondary osteoporosis, which leads to considerable morbidity from fractures. The antiosteoporosis activity of ellipticine...
-
Revisiting Ipriflavone: a Potential Isoflavone for the Management of Postmenopausal Osteoporosis
Ipriflavone is a nutraceutical extensively used in Asian countries since 1890 for postmenopausal osteoporosis as a phytoestrogen to inhibit bone...
-
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2
In a previous study, we discovered that the ethanolic extract of sea buckthorn ( Hippophae rhamnoides ) fruits exhibited anti-osteoporosis effects both...
-
A Novel Case Study of the Use of Real-World Evidence to Support the Registration of an Osteoporosis Product in China
On June 23, 2020, Prolia ® (denosumab) was approved by the National Medical Products Administration (NMPA) in the People’s Republic of China as the...
-
Blockade of the colony-stimulating factor-1 receptor reverses bone loss in osteoporosis mouse models
BackgroundMice lacking either colony-stimulating factor-1 (CSF-1) or its receptor, CSF-1R, display osteopetrosis. Accordingly, genetic deletion or...
-
Artemether Inhibits RANKL-Induced Osteoclast Differentiation and Prevents Bone Loss in Ovariectomized Mice
Bone homeostasis is dynamically balanced by osteoclastic bone resorption and osteoblastic bone formation. Increased numbers and enhanced activities...
-
Effects of phytoestrogens on reproductive organ health
Phytoestrogens are non-steroidal, polyphenolic compounds that are derived from plants and have biological properties similar to those of human...
-
Spectrophotometric Determination of Sodium Prodronate in Tablets for Osteoporosis Treatment
A spectrophotometric method for determining sodium prodronate in tablets by measuring the absorption at 237 ± 2 nm of a Cu(II)—prodronate complex in...
-
Phytoestrogenic Potential of Resveratrol by Selective Activation of Estrogen Receptor-α in Osteoblast Cells
Resveratrol obtained in grape seed and skin is structurally similar to a synthetic estrogen diethylstilbestrol. The endogenous estrogen,...
-
Atractylenolides (I, II, and III): a review of their pharmacology and pharmacokinetics
Atractylodes macrocephala Koidz is a widely used as a traditional Chinese medicine. Atractylenolides (-I, -II, and -III) are a class of lactone...
-
Organ-Based Medicine
The core problem of both medicine and all biomedical research, which would also exist if all research had become reproducible, statistically correct,...
-
Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives
Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third largest family of flowering plants. The genus Sophora comprises...
-
Women’s Health from a Pharmacy Perspective
This chapter looks specifically at the available pharmacist services based evidence in relation to women’s health across the life course. Women’s...
-
Exploring the therapeutic potential of natural compounds modulating the endocannabinoid system in various diseases and disorders: review
Cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes involved in the biosynthesis and degradation of the...
-
Decentralized Clinical Trials: Scientific Considerations Through the Lens of the Estimand Framework
While industry and regulators’ interest in decentralized clinical trials (DCTs) is long-standing, the Covid-19 pandemic accelerated and broadened the...
-
Effect of Cinnamon and Aconite on Bone Formation-Bone Absorption Coupling in Bone Microenvironment
Aconite and cinnamon can treat many diseases. The study aimed to assess the effectiveness and mechanism of aconite, cinnamon, and aconite-cinnamon in...
-
Manage osteoporotic pain by treating osteoporosis and taking a multidimensional approach to pain management
Although osteoporosis is referred as a silent disease due to its asymptomatic nature, many patients experience pain from osteoporosis-related...
-
Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand
GPR35, an orphan receptor, has been waiting for its ligand since its cloning in 1998. Many endogenous and exogenous molecules have been suggested to...
-
The potential health benefits of the isoflavone glycoside genistin
Genistin is a type of isoflavone glycoside and has a broad range of health benefits. It is found in a variety of dietary plants, such as soybean,...
