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Integrative opioid-GABAergic neuronal mechanisms regulating dopamine efflux in the nucleus accumbens of freely moving animals
The nucleus accumbens (NAc) is a terminal region of mesocorticolimbic dopamine (DA) neuronal projections from the ventral tegmental area. Accumbal DA...
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Further proof on the role of accumbal nNOS in cocaine-seeking behavior in rats
BackgroundCocaine use disorder (CUD) remains a severe health problem with no effective pharmacological therapy. One of the potential pharmacological...
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Network analysis of monoamines involved in anxiety-like behavior in a rat model of osteoarthritis
BackgroundChronic pain is a major health problem that affects a significant number of patients, resulting in personal suffering and substantial...
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The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents
Novel psychoactive substances (NPSs) are new psychotropic drugs designed to evade substance regulatory policies. 25E-NBOMe...
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Treatment with dopamine β-hydroxylase (DBH) inhibitors prevents morphine use and relapse-like behavior in rats
BackgroundOpioid use disorders are serious contributors to the harms associated with the drug use. Unfortunately, therapeutic interventions for...
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Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats
BackgroundThe results of our previous studies demonstrated that low sensitivity to negative feedback (NF) is associated with increased vulnerability...
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Amphetamine-induced prolonged disturbances in tissue levels of dopamine and serotonin in the rat brain
BackgroundA hallmark of psychostimulants is the persistence of neurobiological changes they produce. The difficulty in reversing long-time effects of...
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The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons
The role of adenosine A2A receptor (A2AR) and striatal-enriched protein tyrosine phosphatase (STEP) interactions in the striatal-pallidal GABA...
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Orexin type-2 receptor blockade prevents the nicotine-induced excitation of nucleus accumbens core neurons in rats: An electrophysiological perspective
BackgroundThe nucleus accumbens core (NAcc) expresses both orexin and nicotinic acetylcholine receptors (nAChRs). Orexin is among important...
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Maternal feeding patterns affect the offspring’s brain: focus on serotonin 5-HT2C and 5-HT2A receptors
BackgroundRecent studies have shown a relationship between the composition of the maternal diet and acquiring a risk of mental illnesses through...
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Neuroendocrine microRNAs linked to energy homeostasis: future therapeutic potential
The brain orchestrates whole-body metabolism through an intricate system involving interneuronal crosstalk and communication. Specifically, a key...
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Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT2C receptor in the mouse brain
BackgroundSerotonin (5-HT) 5-HT 2C receptor mRNA editing (at five sites, A–E), implicated in neuropsychiatric disorders, including clinical...
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Escitalopram alters local expression of noncanonical stress-related neuropeptides in the rat brain via NPS receptor signaling
BackgroundNeuropeptide S (NPS) is a multifunctional regulatory factor that exhibits a potent anxiolytic activity in animal models. However, there are...
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Interactions between metabotropic glutamate and CB1 receptors: implications for mood, cognition, and synaptic signaling based on data from mGluR and CB1R-targeting drugs
Metabotropic glutamate receptors (mGluRs) are part of the G protein-coupled receptors (GPCRs) family. They are coupled to G αq (group I) or G i/o ...
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The role of GPR39 zinc receptor in the modulation of glutamatergic and GABAergic transmission
BackgroundDespite our poor understanding of the pathophysiology of depression, a growing body of evidence indicates the role of both glutamate and...
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Characterization of dopamine D2 receptor coupling to G proteins in postmortem brain of subjects with schizophrenia
BackgroundAlterations of dopamine D 1 (D1R) and D 2 receptor (D2R) are proposed in schizophrenia but brain neuroimaging and postmortem studies have...
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Extinction training following cocaine or MDMA self-administration produces discrete changes in D2-like and mGlu5 receptor density in the rat brain
BackgroundSeveral studies strongly support the role of the dopamine D 2 -like and glutamate mGlu 5 receptors in psychostimulant reward and relapse.
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N-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research
Substance use disorder (SUD) is a chronic brain condition, with compulsive and uncontrollable drug-seeking that leads to long-lasting and harmful...
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Pharmacologic hyperreactivity of kappa opioid receptors in periaqueductal gray matter during alcohol withdrawal syndrome in rats
BackgroundPeriaqueductal gray matter (PAG) is a brain region rich in kappa-opioid receptors (KOR). KOR in PAG mediates behavioral responses related...
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Adaptive mechanisms following antidepressant drugs: Focus on serotonin 5-HT2A receptors
BackgroundThere is a strong support for the role of serotonin (5-HT) neurotransmission in depression and in the mechanism of action of...