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Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases
Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A...
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Dihydroartemisinin inhibits follicular helper T and B cells: implications for systemic lupus erythematosus treatment
Systemic lupus erythematosus (SLE) is a common autoimmune disease, and its pathogenesis mainly involves the aberrant activation of B cells through...
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Safflor Yellow A Protects Beas-2B Cells Against LPS-Induced Injury via Activating Nrf2
Acute lung injury and its severe form acute respiratory distress syndrome are lethal lung diseases. So far, effective therapy for the diseases is...
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Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats
BackgroundPulmonary hypertension (PH) can cause right ventricular (RV) failure and subsequent cardiohepatic syndrome referred to as congestive...
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Shionone Relieves Ulcerative Colitis by Regulating the p38 MAPK/NF-κB Pathway
Ulcerative colitis is a serious intestinal disorder, which can lead to a variety of complications, and in severe cases, the risk of becoming...
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Diosmetin Alleviates Ovalbumin-Induced Nasal Inflammation by Regulating the SIRT1/NF-κB Signaling in Mouse Models of Allergic Rhinitis
Diosmetin is a flavonoid compound with various pharmacological activities, which plays a vital role in alleviating the development of asthma and...
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E1231 Alleviates Diabetic Cardiomyopathy by Regulating the Silent Information Regulator 1/Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α/Nuclear Factor Erythroid 2-Related Factor 2 Pathway
We aimed to investigate the underlying function and mechanism of E1231 against diabetic cardiomyopathy (DCM). H9c2 cells were exposed to either 33...
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Isoacteoside Protects Against Sepsis-Induced Acute Lung Injury by Regulating the SIRT1/Nrf2/NF-κB/NLRP3 Signaling Pathways
Sepsis-related acute lung injury is a severe inflammatory pulmonary disorder. Isoacteoside is a phenylethanoid derived from Monochasma savatieri ...
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Cinnamon Modulates Toll-Like Receptors: a New Therapeutic Approach for Diabetes
AbstractDiabetes mellitus is a chronic metabolic disease with a high global incidence that can lead to serious and life-threatening conditions....
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Role of Atractylenolide I in Cerebral Ischemia Reperfusion Injury
Atractylenolide I is one of the main sesquiterpene lactones of Atractylodes macrocephala Koidz., Asteraceae, and its biological functions involved in...
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Analysis of the Mechanisms of Action of a TSPO Ligand (GML-3 Compound) in a Model of Lipopolysaccharide-Induced Cell Damage
The ability of an 18-kDa translocator protein (TSPO) ligand, a pyrrolo[1,2- a ]pyrazine derivative, represented by N -butyl- N -methyl-1-phenylpyrrolo[1,2-
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Nuclear BK channels regulate CREB phosphorylation in RAW264.7 macrophages
BackgroundMacrophages are important cells of the innate immune system and contribute to a variety of physiological and pathophysiological responses....
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Inhibitory effects of 6′-sialyllactose on angiotensin II-induced proliferation, migration, and osteogenic switching in vascular smooth muscle cells
Excessive production and migration of vascular smooth muscle cells (VSMCs) are associated with vascular remodeling that causes vascular diseases,...
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Liquiritin Relieves Oxygen-Glucose Reperfusion-Induced Neuronal Injury via Inhibition of the p38MAPK/NF-κB Signaling Pathway
In traditional Chinese medicine, liquiritin, an active component of Glycyrrhiza uralensis Fisch . , Fabaceae, has several pharmacological effects such...
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Protective Effect of Ellagic Acid on Induced Liver Injury
The application of one of the most important nonsteroidal anti-inflammatory drugs, diclofenac, has been restricted due to its hepatotoxicity. The...
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Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway
Systemic or hepatic inflammation is caused by intraperitoneal application of lipopolysaccharide (LPS). In this study, we investigated...
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Mechanistic insight on the role of leukotriene receptors in ischemic–reperfusion injury
Leukotrienes (LT) are a class of inflammatory mediators produced by the 5-lipoxygenase (5-LO) enzyme from arachidonic acid (AA). We discussed the...
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6′-Sialylactose abolished lipopolysaccharide-induced inflammation and hyper-permeability in endothelial cells
Disruption of the endothelial barrier function and reduction in cell migration leads to endothelial dysfunction. One of the most abundant human milk...
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Pharmacological Actions of Tanshinone IIA with Special Focus on Nrf-2 Signaling Pathway
Salvia miltiorrhiza Bunge, Lamiaceae, widely recognized as “danshen,” Chinese sage, is an important long-established traditional Chinese medication,...
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Unlocking the Potential of Brusatol as an Antitumoral Agent: Molecular Mechanisms and Therapeutic Benefits
Traditional Chinese medicine relies on brusatol to combat various diseases, including cancer. Considering the wide variety of natural substances and...
