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Hypotensive Effect of Magnolin on Spontaneously Hypertensive Rats by Reversing Nitric Oxide Synthase Uncoupling
Many cardiovascular diseases are associated with endothelial dysfunction and oxidant stress involving NADPH oxidase and uncoupling of endothelial...
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Inhibitors of Nitric Oxide Production from the Seeds of Myristica fragrans: Experimental and Computational Results
This study focuses on the extraction of eleven compounds from Myristica fragrans Houtt., Miristicaceae, seeds, guided by their anti-inflammatory...
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Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism
BackgroundNon-alcoholic steatohepatitis (NASH) is a progressive subtype of non-alcoholic fatty liver disease (NAFLD) that is closely related to...
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Pentylenetetrazole preconditioning attenuates severity of status epilepticus induced by lithium-pilocarpine in male rats: evaluation of opioid/NMDA receptors and nitric oxide pathway
BackgroundNon-deleterious episodes of seizure preconditioning can efficiently increase the brain’s resistance to the consequent severe status...
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Nitric Oxide Inhibitors from the Stem Bark of Biancaea decapetala: An In Vitro and In Silico Study
This study presents the anti-inflammatory potential of compounds isolated from the stem bark of Biancaea decapetala (Roth) O.Deg., Fabaceae. Sixteen...
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Empagliflozin, alone or in combination with liraglutide, limits cell death in vitro: role of oxidative stress and nitric oxide
BackgroundSodium-dependent glucose co-transporter 2 (SGLT2) inhibitor empagliflozin and glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide...
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In-Vitro Effect of Ammodaucus Leucotrichus Flower and Fruit Essential Oils on Nitric Oxide Production and Arginase Activity in Human Peripheral Blood Mononuclear Cells (PBMC) from Patients with Behçet Disease
Ammodaucus leucotrichus is an Algerian aromatic medicinal plant, widely known as “Oum-draiga or Kamoune-l’ibel”. In folk medicine, the flower and...
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Further proof on the role of accumbal nNOS in cocaine-seeking behavior in rats
BackgroundCocaine use disorder (CUD) remains a severe health problem with no effective pharmacological therapy. One of the potential pharmacological...
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Daidzein Relieves Lipopolysaccharide-Induced Mastitis Through Inhibiting MAPKs and AKT/NF-κB P65 Signaling Pathways
Mastitis in dairy cattle is a serious pathological process that causes significant economic losses to the farming industry. Daidzein is a dietary...
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Gastroprotection of Riparin III in the Acute Model of Ethanol-Induced Gastric Lesion in Mice
The present study aims to evaluate the gastroprotective potential of riparin III in the acute model of gastric lesions induced by ethanol in mice....
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Daidzein Attenuates Ovariectomy-Induced Cognitive Deficits by Improving Cortical Endothelial Function in Rats
There have been reports of decreased vascular activity in memory-sensitive brain areas, which is thought to be a different approach to managing...
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Biochemical and histopathological evidence for the beneficial effects of modafinil on the rat model of inflammatory bowel disease: involvement of nitric oxide pathway
BackgroundInflammatory bowel disease is an intestinal disorder presented by recurrent inflammation in the gastrointestinal tract. It has been...
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Relaxing Responses of Isolated Rat Airways to Hydrocotyle umbellata Extract
Although Hydrocotyle umbellata L., Araliaceae, has important biological effects, its actions on the respiratory system have not been verified. The...
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Protective effects of long-term nitrate administration against ovariectomy-induced kidney dysfunction in rats
BackgroundMenopause is associated with higher risks of chronic kidney disease. We determined the effect of nitrate on ovariectomy-induced kidney...
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Therapeutic Effects of Resveratrol in Inflammatory Bowel Diseases: Shedding Light on the Role of Cellular and Molecular Pathways
Inflammatory bowel disease is a debilitating idiopathic inflammatory condition of the gastrointestinal tract. Generally, this illness contains two...
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Comparative study on the impacts of visnagin and its methoxy derivative khellin on human lymphocyte proliferation and Th1/Th2 balance
BackgroundVisnagin is a phenolic and natural compound in turmeric and fenugreek, and its anti-inflammatory effect has been indicated. Therefore, this...
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Luteolin alleviates vascular dysfunctions in CLP-induced polymicrobial sepsis in mice
BackgroundLuteolin, a naturally occurring flavonoid, is thought to have health-promoting properties as a part of human diet and has been reported to...
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Anti-inflammatory, Radical-Scavenging, and Chelating Activities of Nor-Triterpenes from Galphimia Species
Anti-inflammatory and radical-scavenging activities of the methanolic extract from the leaves of Galphimia spp. collected in Morelos, Mexico, and...
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The effects of extended nitric oxide release on responses of the human non-pregnant myometrium to endothelin-1 or vasopressin
BackgroundUterotonic mediators: endothelin-1 (ET-1), arginine vasopressin (AVP), and nitric oxide (NO) play important roles in the regulation of...
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The role of brain gaseous neurotransmitters in anxiety
Although anxiety is perhaps one of the most significant current medical and social problems, the neurochemical mechanistic background of this common...
