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Safety and Effectiveness of Multiple Switching Between Originators and Biosimilars: Literature Review and Status Report on Interchangeability
To date, numerous biosimilars are available in Europe and the practice of switching between originator and biosimilar or between two different...
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Cinnamic Acid Improves Glucose Uptake and Utilization with Concomitant Improvement of Redox and Bioenergetic Homeostasis, While Modulating Glucose-Lipid Metabolic Switch in Isolated Psoas Muscle
The antidiabetic properties of cinnamic acid was investigated in isolated psoas muscles from Sprague Dawley male rats, by studying its ability to...
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The PHASTER Study: Economic and Organizational Impact of Subcutaneous (SC) Pertuzumab and Trastuzumab Fixed-Dose Combination (PH FDC SC) for Treatment of HER2+ Breast Cancer Patients
BackgroundThis study evaluated the impact of using the subcutaneous fixed-dose combination of pertuzumab + trastuzumab (PH FDC SC) compared with...
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Evaluating the impact of price regulation (Drug Price Control Order 2013) on antibiotic sales in India: a quasi-experimental analysis, 2008–2018
BackgroundIn India, due to a lack of population-level financial risk protection mechanisms, the expenditure on healthcare is primarily out-of-pocket...
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Pharmacokinetic Studies of Multiple Active Components in Rat Plasma Using LC-MS/MS after Oral Administration of Shaoyao-Gancao-Fuzi Decoction
Shaoyao-Gancao-Fuzi decoction, a famous traditional Chinese medicine prescription and composed of the roots of Paeonia lactiflora Pall., Paeoniaceae, G...
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Adverse events and monitoring requirements associated with monoclonal antibody therapy in patients with multiple sclerosis
Multiple sclerosis (MS) is treated with a variety of immunomodulatory and immunosuppressive drugs. Among the most potent therapeutic options are...
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Imputation of Missing Data for Time-to-Event Endpoints Using Retrieved Dropouts
We have explored several statistical approaches to impute missing time-to-event data that arise from outcome trials with relatively long follow-up...
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Medicine shortages: impact behind numbers
IntroductionCurrent research to assess the impact that medicine shortages have on patients is limited to general aspects, such as the prevalence of...
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Accurate Collection of Reasons for Treatment Discontinuation to Better Define Estimands in Clinical Trials
BackgroundReasons for treatment discontinuation are important not only to understand the benefit and risk profile of experimental treatments, but...
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Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides
Biological cell membranes are a natural barrier for living cells. In the last few decades, the cell membrane has been the main hurdle in the...
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Advanced therapeutic strategies targeting microglia: beyond neuroinflammation
For a long time, microglia have been recognized as the main culprits of neuroinflammatory responses because they are primary phagocytes present in...
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Maximizing the benefits of using biosimilars in Egypt
BackgroundBiosimilars constitute a pathway for sustainable financing of healthcare systems in the era of expensive biologics. However, such a pathway...
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Theories and Mechanism of Aging and Longevity Through Evolutionary Lens: a Coalition of Plant Anti-oxidants
The response to the dilemma behind “why do we age” and “what are major causes of aging” is inexplicable and it is tantamount to answer the most...
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IN-VITRO Assessment of Anti-Cholinesterase, Anti-Lipase, Antioxidant Activities and Photoprotective Effect of Algerian Fagonia bruguieri DC Extracts
This is the first study aimed to investigate the anti-cholinesterase (anti-Alzheimer), anti-lipase, antioxidant and photoprotective effects of...
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Calibration Methods and Procedures
A set of procedures known as calibration establishes the relationship between the values reported by a measuring device or measuring system and the...
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Recycling Preparative Liquid Chromatography, the Overlooked Methodology for the Purification of Natural Products
Frequently, preparative high-performance liquid chromatography separations of complex natural product mixtures by adsorption chromatography are...
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Chemophenetic and Chemodiversity Approaches: New Insights on Modern Study of Plant Secondary Metabolite Diversity at Different Spatiotemporal and Organizational Scales
The study of plant secondary metabolites, now designated as specialized metabolites, is motivated by multiple scientific objectives, ranging from...
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Sample Size Calculation When Planning Clinical Trials with Intercurrent Events
BackgroundMissing data are not intercurrent events; missing data are consequences of intercurrent events. When planning clinical trials with...
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Neurological consequences of COVID-19
In December 2019, cases of pneumonia caused by infection with the previously unknown severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),...
