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Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions
The emergence of antibody-drug conjugates (ADCs) as a potential therapeutic avenue in cancer treatment has garnered significant attention. By...
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Synthesis of Succinimidyl 4-(N-maleimidomethyl)-Cyclohexane-1-Carboxylate (SMCC) as a Linker and Conjugating Trastuzumab to Maytansinoid Derivative (DM1) Through SMCC as an Antibody-Drug Conjugate
HER2 is overexpressed in 20–25% of breast cancer cases and is responsible for more aggressive tumor behavior. Monoclonal antibodies such as...
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Aducanumab: a review of the first approved amyloid-targeting antibody for Alzheimer’s disease
Aducanumab is a human immunoglobulin G1 monoclonal antibody that binds to the linear epitope formed by amino acids 3–7 of the Aβ peptide, with a...
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Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities
Antibody drug conjugates (ADCs) are promising cancer therapeutics with minimal toxicity as compared to small cytotoxic molecules alone and have shown...
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Remdesivir and SARS-CoV-2 monoclonal antibodies to prevent COVID-19 progression in hematological patients: an observational study
BackgroundPatients with hematological malignancies (HM) are at high risk of COVID-19 progression. Hence, early treatments to prevent progression are...
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Antibody–drug conjugates and bispecific antibodies targeting cancers: applications of click chemistry
Engineering approaches using antibody drug conjugates (ADCs) and bispecific antibodies (bsAbs) are designed to overcome the limitations of...
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Clinical Development and Regulatory Pathways of Monoclonal Antibodies in Japan
The past two decades have seen rapid globalization in the development and distribution of pharmaceutical products. There has been an increasing...
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Formulation Design for Freeze-Drying: Case Studies of Stabilization of Proteins
Formulation design is an integral part of drug product development for parenterally applied dosage forms. In particular for freeze-dried...
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Nirsevimab in the prevention of respiratory syncytial virus lower respiratory tract disease: a profile of its use
Nirsevimab (Beyfortus™), a long-acting monoclonal antibody targeting the respiratory syncytial virus (RSV) fusion (F) protein, is the first...
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Ublituximab in relapsing forms of multiple sclerosis: a profile of its use
Ublituximab (BRIUMVI TM ), an anti-CD20 immunoglobulin G1 monoclonal antibody, is a promising new treatment option for patients with relapsing forms of...
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Consider new therapies for the treatment and prevention of Clostridioides difficile infection
New therapies to treat and prevent Clostridioides difficile infections (CDI) are needed. CDI requires antibiotic therapy, but this can disrupt gut...
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Adverse events and monitoring requirements associated with monoclonal antibody therapy in patients with multiple sclerosis
Multiple sclerosis (MS) is treated with a variety of immunomodulatory and immunosuppressive drugs. Among the most potent therapeutic options are...
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Tezepelumab in severe asthma: a profile of its use
Tezepelumab (tezepelumab-ekko; TEZSPIRE ® ), a first-in-class monoclonal antibody targeting thymic stromal lymphopoietin, represents a novel, effective...
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Lyophilization Validation: Process Qualification and Continued Process Verification
This work describes the lyophilization process validation and consists of two parts. Part I (Part I: Process Design and Modeling) focuses on the...
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Anifrolumab in systemic lupus erythematosus: a profile of its use
Anifrolumab (Saphnelo™), an intravenously administered immunoglobulin G1 kappa monoclonal antibody targeting the type 1 interferon alpha receptor, is...
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Regulatory Perspective of International Agencies for Development of Biosimilar Products (Monoclonal Antibodies): An Overview
Biopharmaceutical medicines are complex molecules obtained from a living organism (plant or animal cells) and may contain components of a living...
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Comparative Study of the Stability of Eculizumab Biosimilar and the Original Drug under Extreme pH, Oxidative Stress, and UV Irradiation Conditions
A study of the degradation profiles of drugs based on recombinant monoclonal antibodies under stress conditions made it possible to determine the...
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Pharmacological Strategies to Overcome Tumor Resistance to Anticancer Hormonal, Targeted, and Immunotherapy
Possible molecular mechanisms of develo** tumor drug resistance to anticancer hormonal, targeted, and immunotherapy that are associated with the...
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Mirvetuximab soravtansine in folate receptor alpha-positive, platinum-resistant ovarian cancers: a profile of its use
Mirvetuximab soravtansine (Elahere TM ), an antibody-drug conjugate carrying a maytansinoid payload targeting folate receptor alpha (FRα), is a...
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Targeted therapy for metastatic colorectal cancer: what do we currently have in clinical practice?
Colorectal cancer (CRC) is one of the three most prevalent types of cancer (along with lung cancer and breast cancer) and the second most deadly...