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Effectiveness and cost-effectiveness of combination therapy versus monotherapy in malignant melanoma
BackgroundUntil 2010, stage III or IV malignant melanoma (MM) had a poor prognosis. The discovery of immune checkpoint inhibitors (ICIs) in 2011...
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Effects of Gαi2 and Gαz protein knockdown on alpha2A-adrenergic and cannabinoid CB1 receptor regulation of MEK-ERK and FADD pathways in mouse cerebral cortex
BackgroundAlpha 2A -adrenergic (α 2A -AR) and cannabinoid CB 1 (CB 1 -R) receptors exert their functions modulating multiple signaling pathways, including...
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MEKs/ERKs-mediated FBXO1/E2Fs interaction interference modulates G1/S cell cycle transition and cancer cell proliferation
E2F 1, 2, and 3a, (refer to as E2Fs) are a subfamily of E2F transcription factor family that play essential roles in cell-cycle progression, DNA...
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ACY-241, an HDAC6 inhibitor, overcomes erlotinib resistance in human pancreatic cancer cells by inducing autophagy
Histone deacetylase 6 (HDAC6) is a promising target for cancer treatment because it regulates cell mobility, protein trafficking, cell growth,...
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Changes in Companion Diagnostic Labelling: Implementation of FDA’s April 2020 Guidance for Industry for In Vitro CDx Labeling for Specific Oncology Therapeutic Groups
Advanced understanding of the molecular pathways of oncologic diseases has shifted therapeutic treatment development to focus on mechanism of actions...
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Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC
Gefitinib, as the first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has achieved great advances in the...
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Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress
The molecular chaperone heat shock protein 90 (HSP90) regulates multiple crucial signalling pathways in cancer by driving the maturation of key...
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Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1+/− mice
BackgroundSynaptic Ras-GTPase-activating protein 1 (SYNGAP1) is an abundant brain-specific protein localized at the postsynaptic density of mammalian...
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Comparative Assessment of Drug Lag for Approved Oncology Targeted Therapies Between Saudi Arabia, the United States, and the European Union
IntroductionPharmaceutical regulation on a global scale is a complex process, with regulatory bodies overseeing various aspects, including licensing,...
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Mediator kinase module proteins, genetic alterations and expression of super-enhancer regulated genes in colorectal cancer
BackgroundGenetic alterations are well characterized as contributors to the pathogenesis of cancers. Epigenetic abnormalities can lead to...
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Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells
Resolution to chemoresistance is a major challenge in patients with advanced-stage malignancies. Thus, identification of action points and...
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Anticancer effect of terpenes: focus on malignant melanoma
Melanoma is a highly aggressive and life-threatening form of skin cancer that accounts for a significant proportion of cancer-related deaths...
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How do phosphodiesterase-5 inhibitors affect cancer? A focus on glioblastoma multiforme
Since the discovery of phosphodiesterase-5 (PDE5) enzyme overexpression in the central nervous system (CNS) malignancies, investigations have...
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Sestrin2 induction contributes to anti-inflammatory responses and cell survival by globular adiponectin in macrophages
Adiponectin, an adipose tissue-derived hormone, exhibits a modulatory effect on cell death/survival and possesses potent anti-inflammatory...
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Molecular-Genetic Basis of Gastrointestinal Stromal Tumor Personalized Therapy by Receptor Tyrosine Kinase Inhibitors (A Review)
Studies of the pharmacotherapy of gastro-intestinal stromal tumor as examples of personalized medicine are reviewed. Peculiarities of the use of...
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Effects of phytoestrogens on reproductive organ health
Phytoestrogens are non-steroidal, polyphenolic compounds that are derived from plants and have biological properties similar to those of human...
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Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy
Natural compounds originating from plants offer a wide range of pharmacological potential and have traditionally been used to treat a wide range of...
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Age Demographics of Subjects Enrolled in Global, Interventional Phase 3 Melanoma Clinical Trials
BackgroundMelanoma is a skin cancer with a rising worldwide incidence of just over 280,000 individuals with the greatest burden of illness in...
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Lipid-lowering drugs and cancer: an updated perspective
Statins and non-statin medications used for the management of dyslipidemia have been shown to possess antitumor properties. Since the use of these...
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Nutraceuticals Derived from Dietary Spices as Candidate Molecules in Targeting Glioma Signaling Pathways
Spices have been used by people for generations as a source of food flavors to increase culinary delicacy. These ingredients not only give the food...
