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One-Pot Multicomponent Synthesis, Antibacterial and Antiproliferative Evaluation of Indole Derivatives
Aseries of indole derivatives 1—3 have been synthesized in moderate to good yields by a one-pot, three-component cyclocondensation reaction of...
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Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents
A new diaminocarbene cis -palladium(II) complex containing a 2-aminobenzoxazole ligand was synthesized by reacting cis -[PdCl 2 (CNCy) 2 ] and...
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STAT3 mediates RCP-induced cancer cell invasion through the NF-κB/Slug/MT1-MMP signaling cascade
Rab coupling protein (RCP) has been known to induce cancer invasion and metastasis, and STAT3 is one of major oncogenic factors. In the present...
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The PIN1-YTHDF1 axis promotes breast tumorigenesis via the m6A-dependent stabilization of AURKA mRNA
The post-transcriptional processing of N 6 -methyladenosine (m 6 A)-modified mRNA by YTH domain-containing family protein 1 (YTHDF1) plays a crucial role...
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Liquid Crystals: Characteristics, Types of Phases and Applications in Drug Delivery
The present review article relates to some theoretical aspects of liquid crystals, particularly types and phases of liquid crystals. In recent years...
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STAT3 transcription factor as target for anti-cancer therapy
AbstractSTATs constitute a large family of transcription activators and transducers of signals that have an important role in many cell functions as...
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Synthesis and Antiproliferative Activity of Imidazole and Triazole Derivatives of Flavonoids
Flavones can play a potential role in estrogen dependent breast cancer due to greater reactivity of imidazole and triazole heterocycles which have...
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Warburg effect and its role in tumourigenesis
Glucose is a crucial molecule in energy production and produces different end products in non-tumourigenic- and tumourigenic tissue metabolism....
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Design, Synthesis and Anticancer Activity of Aza Heterocycles Containing Gallate Moiety (Part III)
Our previously reported compound, 3-(2-hydroxy-3,4-dimethoxyphenyl)-1-phenyl-1 H -pyrazole-4-carbaldehyde (1) , was allowed to react with acetophenone,...
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Genome-wide evidences of bisphenol a toxicity using Schizosaccharomyces pombe
To clarify reliable toxic mechanisms of bisphenol A (BPA), an endocrine disrupting chemical, we approached an alternative animal and whole genome...
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Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line
In spite of advances in colorectal cancer treatments, approximately 1.4 million new global cases are estimated for 2015. In this sense, Brazilian...
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Pro-apoptotic peptides-based cancer therapies: challenges and strategies to enhance therapeutic efficacy
Cancer is a leading cause of death worldwide. Despite many advances in the field of cancer therapy, an effective cure is yet to be found. As a more...
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Synthesis and cytotoxic activity of certain trisubstituted azetidin-2-one derivatives as a cis-restricted combretastatin A-4 analogues
Novel series of 1,3,4-trisubstituted azetidin-2-one derivatives 8a – p were synthesized and proposed as cytotoxic agents acting via inhibition of...
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Terpenoid composition and the anticancer activity of Acanthopanax trifoliatus
The petroleum ether and ethyl acetate fractions of extract from an edible and medicinal plant Acanthopanax trifoliatus were found to show significant...
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Two New Cytotoxic C-29 Steroids from the Red Sea Brown Alga Cystoseira trinodis
Chromatographic fractionation of the organic extract obtained from the brown alga Cystoseira trinodis led to the isolation of a known carotene...
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The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment
Nrf2 acts as a sensor of oxidative or electrophilic stress and prevents genome instability. The activation of Nrf2 signaling induces ARE-dependent...
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Anti-inflammatory, analgesic and anti-tumor properties of gold nanoparticles
BackgroundGold nanoparticles (GNPs) are regarded as potential platforms for drug delivery. However, their interaction with live organisms must be...
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Recombinant human interleukin 24 reverses Adriamycin resistance in a human breast cancer cell line
Background : The major cause of multidrug resistance is over-expression of membrane P-glycoprotein (P-gp). We investigated the effect of recombinant...
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Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways
BackgroundBisdemethoxycurcumin (BDMC) is a natural derivative of curcumin present in the phenolic components extracted from the dried rhizome of Curcu...
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