Search
Search Results
-
Long-term topical corticosteroid treatment for atopic dermatitis: an in-depth analysis of safety, efficacy, withdrawal, and patient experiences
Atopic dermatitis, often referred to as eczema, is classified as a chronic inflammatory skin disorder with increasing prevalence. Topical...
-
Pharmacologic hyperreactivity of kappa opioid receptors in periaqueductal gray matter during alcohol withdrawal syndrome in rats
BackgroundPeriaqueductal gray matter (PAG) is a brain region rich in kappa-opioid receptors (KOR). KOR in PAG mediates behavioral responses related...
-
Pharmacological management of psychoactive substance withdrawal syndrome
RationaleMedications are available to manage alcohol and drug withdrawal, but they are underutilized. Only a handful, such as methadone,...
-
Molecular pattern of a decrease in the rewarding effect of cocaine after an escalating-dose drug regimen
BackgroundLong-term cocaine exposure leads to dysregulation of the reward system and initiates processes that ultimately weaken its rewarding...
-
Long-term use of systemic azole antifungals can result in hepatotoxicity and other serious adverse effects
Long-term use of systemic azole antifungals (i.e. fluconazole, isavuconazole, itraconazole, ketoconazole, posaconazole and voriconazole) can result...
-
Opioid misuse in older patients requires careful consideration of many factors
There is insufficient clinical data on how to optimally treat and manage opioid misuse in older patients. Opioid use affects older adults differently...
-
Educate patients with medication overuse headache, and intervene, when necessary
Medication overuse headache (MOH) most commonly affects people with migraine, particularly in patients who overuse medications intended for...
-
Pharmacovigilance to Inform Drug Safety: Challenges and Opportunities
Pharmacovigilance is vital to ensure the short-term and long-term safety of medications and other medicinal substances. Both active and passive...
-
Sparsentan in immunoglobulin A nephropathy: a profile of its use
Sparsentan (FILSPARI ® ), an oral, dual endothelin and angiotensin receptor antagonist, is an emerging new treatment option for patients with...
-
Amantadine extended release capsules (GOCOVRI®) in Parkinson’s disease: a profile of its use in the USA
Amantadine extended release (ER) [GOCOVRI ® ], an NMDA receptor antagonist, is an important treatment option in the management of levodopa-induced...
-
Eczematous drug eruptions mostly manageable with emollients and corticosteroids
Eczematous drug eruptions (EDEs) constitute up to 10% of cutaneous drug reactions, with biologics and some newer cancer treatments and antivirals...
-
Further proof on the role of accumbal nNOS in cocaine-seeking behavior in rats
BackgroundCocaine use disorder (CUD) remains a severe health problem with no effective pharmacological therapy. One of the potential pharmacological...
-
Effects of Chrysin on mRNA Expression of 5-HT1A and 5-HT2A Receptors in the Raphe Nuclei and Hippocampus
5-Hydroxytryptamine-1A and 5-hydroxytryptamine-2A receptors have been widely related to the mechanism of action of antidepressant drugs. However, the...
-
Gout plus cardiovascular disease is painful, but treatable
Gout often coexists with and worsens cardiovascular disease (CVD) or CVD risk factors. Effective gout management reduces CVD deterioration, which...
-
Central nervous system disorders after use of dolutegravir: evidence from preclinical and clinical studies
The evaluation of dolutegravir based on available preclinical and clinical studies reveals a risk of central nervous system (CNS) disorders...
-
Characteristics of Anticancer Drugs Approved Under the Accelerated Approval Program in the US: Success or Failure in Converting to Regular Approval
BackgroundAccelerated approval (AA) program expedites access to promising drugs for life-threatening conditions, particularly in oncology. However,...
-
MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments
BackgroundSynthetic cathinones (SC) constitute the second most frequently abused class of new psychoactive substances. They serve as an alternative...
-
The effect of phencyclidine-mediated blockade of NMDA receptors in the early postnatal period on glutathione and sulfur amino acid levels in the rat brain as a potential causative factor of schizophrenia-like behavior in adulthood
BackgroundPhencyclidine, an NMDA receptor antagonist, is frequently used to model behavioral and neurochemical changes correlated with schizophrenia...
-
Chronic cerebral hypoperfusion-induced memory impairment and hippocampal long-term potentiation deficits are improved by cholinergic stimulation in rats
BackgroundChronic cerebral hypoperfusion (CCH) can induce the accumulation of reactive oxygen species, which leads to oxidative damage, neuronal...
-
Buprenorphine extended-release injection (Brixadi®) in the management of opioid use disorder: a profile of its use in the USA
Buprenorphine extended-release (ER) injection for subcutaneous use (Brixadi ® ; CAM2038; hereafter referred to as buprenorphine ER) is a useful...