Search
Search Results
-
The Role of Apelin and Protamine Sulfate in Bile Duct Ligation-Induced Liver Fibrosis in Rats
This study was designed to investigate the effectiveness of protamine sulfate as an apelin receptor blocker on cholestatic liver fibrosis persuaded...
-
The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver
BackgroundOur recent studies showed that prolonged administration of novel atypical antipsychotics affected the expression and activity of cytochrome...
-
Non-alcoholic fatty liver disease and liver secretome
Metabolism of carbohydrates and lipids and protein degradation occurs in the liver and contributes to the body's homeostasis by secreting a variety...
-
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
Pyrrolizidine alkaloids (PAs) are potent hepatotoxins that can cause liver damage. Hyperoside (Hyp), a natural flavonoid, can be extracted from...
-
The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats
BackgroundLiver cytochrome P450 (CYP) greatly contributes to the metabolism of endogenous substances and drugs. Recent studies have demonstrated that...
-
CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats
BackgroundStrong opioid analgesics such as morphine alleviate moderate to severe acute nociceptive pain (e.g. post-surgical or post-trauma pain) as...
-
Oleuropein as a Therapeutic Agent for Non-alcoholic Fatty Liver Disease During Hepatitis C
Hepatitis C is defined as an infection of hepatocytes by the hepatitis C virus that affects hepatocellular signaling pathways and can lead to...
-
An Innovatory GABA Receptor Modulator and Liver Oxidase System Microsomal Cytochrome P450 Activator in Patients with Alcoholism
Molecular docking studies (in Schrödinger and Glide software) showed that the molecule m-Cl-BHU ( meta -chlorobenzhydrylurea) is complementary to the...
-
Resveratrol Attenuates Non-alcoholic Fatty Liver Disease in Obese Mice Modulating MAF1
In the present study, we aimed to evaluate the resveratrol effects on MAF1 liver pathway using a mice model of non-alcoholic fatty liver disease...
-
Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight
Alcoholic liver disease (ALD) refers to hepatic ailments induced by excessive alcohol intake. The pathogenesis of ALD comprises a complex interplay...
-
Selected transgenic murine models of human autoimmune liver diseases
Murine models of human diseases are of outmost importance for both studying molecular mechanisms driving their development and testing new treatment...
-
Voltage-clamp evidence of GABAA receptor subunit-specific effects: pharmacodynamic fingerprint of chlornordiazepam, the major active metabolite of mexazolam, as compared to alprazolam, bromazepam, and zolpidem
BackgroundAnxiolytic benzodiazepines, due to their clinical effectiveness, are one of the most prescribed drugs worldwide, despite being associated...
-
Agents for the treatment of fatty liver disease: focus on essential phospholipids
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed countries, with a prevalence that is increasing. In...
-
Ganoderic acid A attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation
Ganoderic Acid A (GA) has many pharmacological effects such as anti-tumor, antibacterial, anti-inflammatory, and immunosuppressive effects. However,...
-
Hepatic drug-metabolizing enzymes and drug transporters in Wilson’s disease patients with liver failure
BackgroundWilson’s disease is a genetic disorder inherited in a recessive manner, caused by mutations in the copper-transporter ATP7B. Although it is...
-
Metabolic and cardiovascular benefits and risks of 4-hydroxy guanabenz hydrochloride: α2-adrenoceptor and trace amine-associated receptor 1 ligand
Backgroundα 2 -adrenoceptor ligands have been investigated as potential therapeutic agents for the treatment of obesity. Our previous studies have...
-
Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology
Formyl peptide receptors (FPRs) belong to the family of seven-transmembrane G protein-coupled receptors. Among them, FPR2 is a low affinity receptor...
-
Investigation of Eurycoma longifolia Extract on Alleviating Steatosis by Using In Vivo and In Vitro Steatotic Models: Mechanisms Through Activation of AMPK and Autophagic Flux
Eurycoma longifolia Jack, Simaroubaceae, is a popular tropical herb native to Southeast Asia, known for its medicinal properties. This study aimed to...
-
The reference liver—CYP450 and UGT enzymes in healthy donor and metastatic livers: the impact of genotype
BackgroundHepatic enzymes involved in drug metabolism vary markedly in expression, abundance and activity, which affects individual susceptibility to...
-
Emerging roles of ferroptosis in liver pathophysiology
Ferroptosis is a widely recognized process of regulated cell death linking redox state, metabolism, and human health. It is considered a defense...
