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Bruceine D Sensitizes Human Ovarian Cancer Cells to Paclitaxel Through JNK and STAT3 Signal Regulation
Exploring novel regimens is essential to ensure the efficacy of paclitaxel-based chemotherapy in epithelial ovarian cancer. Brucea javanica (L.)...
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JNK signaling as a target for anticancer therapy
The JNKs are members of mitogen-activated protein kinases (MAPK) which regulate many physiological processes including inflammatory responses,...
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Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway
Over the past 100 years, Salvia miltiorrhiza f. alba (Lamiaceae) (RSMA) roots have been used to cure thromboangiitis obliterans (TAO) in local...
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Inhibitory effects of 6′-sialyllactose on angiotensin II-induced proliferation, migration, and osteogenic switching in vascular smooth muscle cells
Excessive production and migration of vascular smooth muscle cells (VSMCs) are associated with vascular remodeling that causes vascular diseases,...
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Morusin, from the Root Bark of Morus alba, Ameliorates Bronchial Epithelial Cell Damage Induced by Cigarette Smoke
Cigarette smoke is the most prevalent risk factor for chronic obstructive pulmonary disease. Morusin is prenylated flavonoid derived from the root...
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Therapeutic action against chronic cholestatic liver injury by low-dose fenofibrate involves anti-chemotaxis via JNK–AP1–CCL2/CXCL2 signaling
BackgroundFenofibrate was reported to be beneficial for cholestasis in combination with ursodeoxycholic acid. However, its therapeutic action as...
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Ginsenoside Rg1 ameliorates palmitic acid-induced insulin resistance in HepG2 cells in association with modulating Akt and JNK activity
BackgroundHepatic insulin resistance can be induced by excess dietary intake of saturated fat. Ginsenoside Rg1 (GRg1), the major active ginsenoside...
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6′-Sialylactose abolished lipopolysaccharide-induced inflammation and hyper-permeability in endothelial cells
Disruption of the endothelial barrier function and reduction in cell migration leads to endothelial dysfunction. One of the most abundant human milk...
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Maternal l-thyroxine treatment during lactation affects learning and anxiety-like behaviors but not spatial memory in adult rat progeny
BackgroundThe present study compared behavioral and molecular indicators of hippocampal function in l -thyroxine treated rats to determine whether...
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Daidzein Relieves Lipopolysaccharide-Induced Mastitis Through Inhibiting MAPKs and AKT/NF-ÎşB P65 Signaling Pathways
Mastitis in dairy cattle is a serious pathological process that causes significant economic losses to the farming industry. Daidzein is a dietary...
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Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells
Resolution to chemoresistance is a major challenge in patients with advanced-stage malignancies. Thus, identification of action points and...
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Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway
BackgroundExcessive stress, a major problem in modern societies, affects people of all ages worldwide. Corticosterone is one of the most abundant...
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Ginsenoside Rg5 as an anticancer drug: a comprehensive review on mechanisms, structure–activity relationship, and prospects for clinical advancement
Cancer remains one of the leading causes of death in the world. Despite the considerable success of conventional treatment strategies, the incidence...
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Phytochemistry and pharmacology of natural prenylated flavonoids
Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The...
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Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
Fibrosis, the excessive deposition of fibrous connective tissue in an organ in response to injury, is a pathological condition affecting many...
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Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy
Natural compounds originating from plants offer a wide range of pharmacological potential and have traditionally been used to treat a wide range of...
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Azadirone from Toona sinensis possesses anti-inflammatory and analgesic activities via suppressing MAPK signal pathway
This study was designed to investigate the anti-inflammatory, analgesic activity of azadirone from Toona sinensis (Juss.) M. Roem., Meliaceae, and...
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Potential biological functions and future perspectives of sialylated milk oligosaccharides
Sialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides (BMOs). First, the safety...
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Pristimerin: Natural Occurrence, Biosynthesis, Pharmacology, and Pharmacokinetics
Pristimerin is a naturally occurring triterpenoid originally isolated from plant members of the genus Pristimera Miers, Celastraceae, and can be also...
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Mechanistic interplay of various mediators involved in mediating the neuroprotective effect of daphnetin
Daphnetin is a 7, 8 dihydroxy coumarin isolated from different medicinal plants of the Thymelaeaceae family and exhibits copious pharmacological...
