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1. Ubiquitin–proteasome system as a target for anticancer treatment—an update

   As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the dysregulation or aberrant expression of the UPS components...

   Yeon Jung Kim, Yeonjoo Lee, ... Eun Joo Song in Archives of Pharmacal Research

   Article 01 July 2023
   

2. Exploring the therapeutic potential of natural compounds modulating the endocannabinoid system in various diseases and disorders: review

   Cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes involved in the biosynthesis and degradation of the...

   Gidion Wilson, Lingling Yang, ... Xueqin Ma in Pharmacological Reports

   Article 31 October 2023
   

3. Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases

   Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a DNA sensor that elicits a robust type I interferon response by...

   ** Kyung Seok, Minhyuk Kim, ... Joo Young Lee in Archives of Pharmacal Research

   Article Open access 24 June 2023
   

4. Anti-dengue Potential of Mangiferin: Intricate Network of Dengue to Human Genes

   Dengue fever has become one of the deadliest infectious diseases and requires the development of effective antiviral therapies. It is caused by...

   K. Kalaimathi, J. Maria Jancy Rani, ... G. Varatharaju in Revista Brasileira de Farmacognosia

   Article 07 May 2022
   

5. Effectiveness of different treatment regimens on patients with COVID-19, hospitalized in Sanandaj hospitals: a retrospective cohort study

   Objectives

   Different drugs have different effects on the prognosis of patients with COVID-19. This study aimed to evaluate the effect of different...

   Jalal Asadi, Mohammad Aziz Rasouli, ... Ghobad Moradi in Journal of Pharmaceutical Policy and Practice

   Article Open access 16 January 2023
   

6. Anifrolumab in systemic lupus erythematosus: a profile of its use

   Anifrolumab (Saphnelo™), an intravenously administered immunoglobulin G1 kappa monoclonal antibody targeting the type 1 interferon alpha receptor, is...

   Yvette N. Lamb in Drugs & Therapy Perspectives

   Article 13 July 2022
   

7. Oral Effect of Tridax procumbens, Allium sativum, and (3S)-16,17-Didehydrofalcarinol in a Murine Model of Cutaneous Leishmaniasis

   The oral effect of Tridax procumbens L., Asteraceae, methanolic extract and (3 S )-16,17-didehydrofalcarinol (an oxylipin) alone or in combination with A...

   Laureni Ferrer-Lino, Blanca Marina Vera-Ku, ... Elsy Nalleli Loría-Cervera in Revista Brasileira de Farmacognosia

   Article 29 September 2022
   

8. Comparative study on the impacts of visnagin and its methoxy derivative khellin on human lymphocyte proliferation and Th₁/Th₂ balance

   Background

   Visnagin is a phenolic and natural compound in turmeric and fenugreek, and its anti-inflammatory effect has been indicated. Therefore, this...

   Vahid Reza Askari, Zohreh Najafi, ... Mohammad Hossein Boskabady in Pharmacological Reports

   Article 06 February 2023
   

9. Prioritizing Early Disease Intervention

   Scholars and practitioners have described how investing in health care earlier rather than later can be beneficial, from how “biomarkers” offer...

   H. Hugo Caicedo, Jonathan J. Darrow, ... Alex Pentland in Therapeutic Innovation & Regulatory Science

   Article 05 September 2023

10. Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases

    Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A...

    Veerta Sharma, Prateek Sharma, Thakur Gurjeet Singh in Pharmacological Reports

    Article 25 June 2024
    

11. Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins

    Innate immunity is one of the most ancient and conserved aspect of the immune system. It is responsible for an anti-infective response and has been...

    Ka Man Tse, Osamu Takeuchi in Archives of Pharmacal Research

    Article 01 February 2023
    

12. Cinnamon Modulates Toll-Like Receptors: a New Therapeutic Approach for Diabetes

    Abstract

    Diabetes mellitus is a chronic metabolic disease with a high global incidence that can lead to serious and life-threatening conditions....

    Amirhossein Niknejad, Seyed Mehrad Razavi, ... Saeideh Momtaz in Revista Brasileira de Farmacognosia

    Article 16 November 2023
    

13. Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy

    The COVID-19 pandemic that started in 2019 and resulted in significant morbidity and mortality continues to be a significant global health challenge,...

    Mahdi Vajdi, Arash Karimi, ... Amirhossein Sahebkar in Pharmacological Reports

    Article 18 March 2024
    

14. Postmarketing Safety of Biosimilars: Current Status, Challenges, and Opportunities in the Spontaneous Reporting System

    Recombinant drug products successfully treat many life-threatening and chronic diseases. The high cost of these drugs makes them inaccessible to the...

    Abhishek Singh, Muthusamy Kalaivani, ... Suresh K. Gupta in Therapeutic Innovation & Regulatory Science

    Article 06 January 2020

15. Evaluation of nano-curcumin against inhaled paraquat-induced lung injury in rats

    Background

    Acute lung injury (ALI) remains a significant source of morbidity and mortality in critically ill patients and currently there is no...

    Seyedeh Zahra Ghasemi, Sima Beigoli, ... Mohammad Hossein Boskabady in Pharmacological Reports

    Article 11 April 2023
    

16. Ozanimod in relapsing forms of multiple sclerosis: a profile of its use

    Ozanimod (Zeposia ^® ), a sphingosine 1-phosphate (S1P) receptor modulator with high selectivity for S1P receptor subtypes 1 and 5 (S1P ₁ and S1P ₅ ),...

    Matt Shirley in Drugs & Therapy Perspectives

    Article 11 February 2021

17. Potential biological functions and future perspectives of sialylated milk oligosaccharides

    Sialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides (BMOs). First, the safety...

    Thuy Le Lam Nguyen, Dung Van Nguyen, Kyung-Sun Heo in Archives of Pharmacal Research

    Article 01 April 2024
    

18. Antiviral drug research for Japanese encephalitis: an updated review

    Japanese encephalitis (JE) caused by the Japanese encephalitis virus (JEV) is one of Asia's most common viral encephalitis. JEV is a flavivirus,...

    Shaun Joe, Abdul Ajees Abdul Salam, ... Piya Paul Mudgal in Pharmacological Reports

    Article Open access 19 February 2022
    

19. Design and Physicochemical Characterization of Lysozyme Loaded Niosomal Formulations as a New Controlled Delivery System

    Lysozyme loaded niosomes containing various molar ratios of two kinds of surfactants were prepared and the properties of these niosomal formulations...

    Somayeh Sadeghi, Parastoo Ehsani, ... Dariush Norouzian in Pharmaceutical Chemistry Journal

    Article 16 January 2020
    

20. Review on pharmacological effects of gastrodin

    Gastrodia elata Blume is a well-known traditional Chinese medicine that is mainly used to treat diseases related to the nervous system, such as...

    Guirong **ao, Rong Tang, ... Yanhua Chen in Archives of Pharmacal Research

    Article 25 September 2023