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Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-κB-p65/p38-MAPK, IL-6/STAT-3, PPAR-γ, and SIRT1/FOXO3 signaling pathways
The present study was designed to evaluate the potential renoprotective impacts of apocynin (APC) against nephrotoxicity induced by methotrexate...
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Daidzein Relieves Lipopolysaccharide-Induced Mastitis Through Inhibiting MAPKs and AKT/NF-κB P65 Signaling Pathways
Mastitis in dairy cattle is a serious pathological process that causes significant economic losses to the farming industry. Daidzein is a dietary...
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Anti-ulcerogenic Properties of Sphaeralcea angustifolia on Gastric Ulcer in Mice
Sphaeralcea angustifolia Cav. G. Don, Malvaceae, is a medicinal plant used to treat inflammatory and gastric diseases. Scopoletin, present in the...
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Study on the Anti-inflammatory Activity of N-(E)-p-Coumaroyl Tyrosine In Vitro and In Vivo
N -( E )- p -Coumaroyl tyrosine is a phenolic amino acid derivative extracted from the Abrus mollis Hance, Syn of Abrus melanospermus subsp. melanospermus ,...
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In Vitro Study of the Cytotoxic and Immunotropic Effects of Molnupiravir and Favipiravir
The effects of the antiviral drugs molnupiravir and favipiravir on the viability of human embryonic lung cells and the production of cytokines by...
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Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats
BackgroundPulmonary hypertension (PH) can cause right ventricular (RV) failure and subsequent cardiohepatic syndrome referred to as congestive...
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Essential phospholipids impact cytokine secretion and alter lipid-metabolizing enzymes in human hepatocyte cell lines
BackgroundEssential phospholipids (EPL) are hepatoprotective.
MethodsThe effects on interleukin (IL)-6 and -8 secretion and on certain...
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Emodin Alleviates the Th17/Treg Imbalance by Targeting Myd88/NF-κB Signaling in Subacute Thyroiditis
Subacute thyroiditis, an immune response of the thyroid gland, is associated with the imbalance of the Th17/Treg ratio. Emodin has been proven to...
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Uliginosin B, a Natural Phloroglucinol, Increases Hippocampal GSH, MCP-1 and IL-10 Levels in Mice
The activation of immuno-inflammatory pathways and oxidative/nitrosative stress results in behavioral, neurochemical, and neuroendocrine...
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Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways
Acute lung injury (ALI) is the leading cause of respiratory diseases induced by uncontrolled inflammation and cell death. Lipopolysaccharide (LPS) is...
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Calycosin Alleviates Lupus Nephritis by Activating the Nrf2/HO-1 Signaling Pathway
Lupus nephritis is a serious condition, for which treatments are limited; hence, there is a need for new cure approaches. The aim of this study was...
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Patuletin from Tagetes patula: an Inhibitor of MMP-2 and MMP-9 in Collagen-Induced Arthritis Rat Model and Virtual Screening Analysis
Patuletin is a flavonoid found in a variety of plants used in traditional folk medicine. It has a wide range of pharmacological effects, including...
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In Vivo Study to Explore the Antiarthritic Potential of Tiliroside on Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats
The purpose of this research was to examine the pharmacological properties and potential mechanism of action of tiliroside in rheumatoid arthritis....
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The Role of Apelin and Protamine Sulfate in Bile Duct Ligation-Induced Liver Fibrosis in Rats
This study was designed to investigate the effectiveness of protamine sulfate as an apelin receptor blocker on cholestatic liver fibrosis persuaded...
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A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice
BackgroundIA-0130 is a derivative of 3-(1,3-diarylallylidene)oxindoles, which is a selective estrogen receptor modulator (SERM). A previous study...
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Influence of Urolithin a on Cytokine Production by Various Cancer Cell Lines
Urolithin A is a polyphenolic metabolite of ellagic acid and ellagitannins that is produced by the intestinal microbiota and has a higher...
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Jacareubin inhibits TLR4-induced lung inflammatory response caused by the RBD domain of SARS-CoV-2 Spike protein
BackgroundCOVID-19, the disease caused by SARS-CoV-2 virus infection, has been a major public health problem worldwide in the last 2 years....
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Matricin Modulates Carbamazepine-Induced Acute Tubulointerstitial Nephritis in Rat Models of Alzheimer’s Disease via MEK-JAK2-STAT3 Signaling
Carbamazepine is a first-choice anticonvulsant, and its medication is typically well tolerated when compared to lithium and valproic acid. Patients...
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Dihydroartemisinin inhibits follicular helper T and B cells: implications for systemic lupus erythematosus treatment
Systemic lupus erythematosus (SLE) is a common autoimmune disease, and its pathogenesis mainly involves the aberrant activation of B cells through...
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Inhibitory Effects and Related Molecular Mechanisms of Huanglian-Ganjiang Combination Against H1N1 Influenza Virus
Influenza is an infectious acute respiratory disease with complications and a high mortality rate; the effective medicines for influenza therapy are...
