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In Silico Studies and DNA Cleavage, Antioxidant, Acetylcholinesterase, and Butyrylcholinesterase Activity Evaluation of Bis-Histamine Schiff Bases and Bis-Spinaceamine Substituted Derivatives
In this work, a series of seven bis-histamine Schiff bases ( H1–H4 ) and bis-spinaceamine substituted derivatives ( SPH1 , SPH2 , and SPH4 ) were...
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Diosmetin Alleviates Ovalbumin-Induced Nasal Inflammation by Regulating the SIRT1/NF-κB Signaling in Mouse Models of Allergic Rhinitis
Diosmetin is a flavonoid compound with various pharmacological activities, which plays a vital role in alleviating the development of asthma and...
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Anti-asthmatic Activity of Liriodendrin Against Ovalbumin-Induced Asthma in Mice via Attenuating TNF-α
Asthma is a serious hypersensitive allergic manifestation and frequently becomes life-threatening if not managed well in time. However, the...
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cis-Jasmone: Phytopharmaceutical Potential for the Treatment of Skin Inflammation
cis -Jasmone is known to activate plan resistance to insects. There are few reports of its pharmacological potential, and this paper presents the...
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Novel object recognition test as an alternative approach to assessing the pharmacological profile of sigma-1 receptor ligands
BackgroundAlthough the terms “agonist” and “antagonist” have been used to classify sigma-1 receptor (σ 1 R) ligands, an unambiguous definition of the...
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New Non-Carboxylic Acid Chalcones as Anti-Inflammatory Agents: Molecular Docking, Synthesis and Admet Studies
Chalcones in combination with heterocyclic moieties have been reported to exhibit diverse biological activities. The present study was aimed to...
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A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective
The neural mechanisms and the receptors behind the course of chemotherapy-induced nausea and vomiting (CINV) are well described and considered...
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Pharmacological Properties of Acetylsalicylic Acid and its Complex with Glycyrrhizic Acid as a Promising Dosage form (Review)
The review summarizes current literature data on the mechanism of antithrombotic, anti-inflammatory, and antipyretic effects of acetylsalicylic acid...
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The Prophylactic Effects of Isosteviol Aerosol Inhalation on Bronchial Asthma in Mice
The diterpenoid isosteviol is one of the stevia derivatives that have reported various activities . In mice inhaling isosteviol, OVA- and ACh-induced...
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Anti-Inflammatory and Analgesic Activity of Ethanolic Extract of Tubers and Different Fractions of Eulophia nuda Lindl.
Recently, in human and animal diseases, inflammation and pain have become the focus of scientific research as it affects more people than any other...
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Emodin Attenuates Ozone-Induced Lung Injury Via TLR4/MYD88/NF-κB Signaling Pathways
In defense of the internal and external environment of the lung airway, airway epithelial cells play important roles in resisting external...
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Effect of long-term administration of ranitidine, a histamine H2 receptor antagonist, on bone metabolism in young growing rats
BackgroundHistamine regulates function of osteoclasts and osteoblasts, however data regarding the influence of histamine H2 receptors antagonists on...
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Urinary Excretion Kinetics of 9-(2-Diethylaminoethyl)-2-Phenylimidazo[1,2-a]Benzimidazole Dinitrate and Determination of the Main Metabolite in Blood Serum of Laboratory Animals
Urinary excretion of 9-(2-diethylaminoethyl)-2-phenylimidazo[1,2- a ]benzimidazole dinitrate after intragastric administration at a dose of 10 mg/kg...
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Antipsychotic drug—aripiprazole against schizophrenia, its therapeutic and metabolic effects associated with gene polymorphisms
Second-generation antipsychotics are widely used for the treatment of schizophrenia. Aripiprazole (ARI) is classified as a third-generation...
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Inhibitory effects of orientin in mast cell-mediated allergic inflammation
BackgroundMast cells are immune effector cells mediating allergic inflammation by the secretion of inflammatory mediators such as histamine and...
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Caffeic acid phenethyl ester inhibits pseudo-allergic reactions via inhibition of MRGPRX2/MrgprB2-dependent mast cell degranulation
Mast cells play essential role in allergic reactions through the process called mast cell degranulation. Recent studies have found that a basic...
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In Vivo Investigations of Analgesic, Antipyretic and Anthelmintic Activities of Various Extracts of Fernandoa adenophylla
Fernandoa adenophylla is well-known Thai medicinal tree used for treating skin disorders, as antiviral, antihypertensive, antidiabetic, and...
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Rosmarinus officinalis Volatile Oil Nanogel Modulated Muscle Damage Induced by Bothrops moojeni Venom: a Phonophoresis Method
Bothrops moojeni venom contains toxins that induce local toxic effects, leading to a severe inflammatory process, pain, hemorrhage, edema, and...
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Management of antipsychotic-induced constipation requires more attention
Constipation is a common adverse effect of antipsychotic therapy that remains understudied and underreported. Weekly constipation screening,...
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Gastroprotection of Riparin III in the Acute Model of Ethanol-Induced Gastric Lesion in Mice
The present study aims to evaluate the gastroprotective potential of riparin III in the acute model of gastric lesions induced by ethanol in mice....
