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The Role of the HL-10 Peptide in Regulating the Expression of Apoptosis-Related Genes in the HeLa Cancer Cell Line
Anticancer peptides are among the most important bioactive peptides found in animal sources. The modulation of the molecular process of apoptosis via...
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Hepatoprotective Xanthones from the Aerial Parts of Pyrethrum tatsienense
A new xanthone, named 1,3,5,9-tetrahydroxy-2-prenyl-4-(3′′ -hydroxy-3′′ -methylbutanoyl)-6,6- dimethylpyranoxanthen-10-one ( 1 ), along with five known...
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Association between health literacy and medication comprehension; attitudes toward reporting adverse events in adults using over-the-counter medicines
BackgroundSelf-medication using over-the-counter (OTC) medicines is one of the effective self-care measures in dealing with daily health problems....
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Metabolomic Profiling and Cytotoxic Activity of Launaea nudicaulis: Molecular Docking with Topoisomerases
Launaea nudicaulis (L.) Hook. f., Asteraceae, is a wild plant growing in Egypt, used traditionally for treatment of many diseases. LC-HRMS analysis...
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Cytotoxic Isopimarane Diterpenoids from Kaempferia koratensis Rhizomes
Two new isopimarane diterpenoids, koratanes A and B, were identified from the rhizomes of Kaempferia koratensis Picheans., Zingiberaceae, together...
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Comparative Study on Phytochemical Profiles, Antiproliferative, Antimicrobial and Antioxidant Activities of Adonis Species from Turkey
The present study aimed to determine antiproliferative, antimicrobial, antioxidant activities and also phytochemical composition of different nine...
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Triterpenoids from Dysoxylum genus and their biological activities
This study aims to analyze the ethnobotanical, chemical, and biological activities of triterpenoid compounds isolated from the Dysoxylum genus of the...
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Anticancer Activity–Structure Relationship of Quinolinone-Core Compounds: An Overall Review
Quinolinone/quinoline is one of the most unique structures in the discovery of heterocycles that have attracted much attention in the field of...
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Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis
Strains of the fungal genus Pestalotiopsis are reported as large promising sources of structurally varied biologically active metabolites. Many...
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New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Gymnopilus orientispectabilis , also known as “big laughter mushroom,” is a hallucinogenic poisonous mushroom that causes excessive laughter upon...
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Three novel piperidones exhibit tumor-selective cytotoxicity on leukemia cells via protein degradation and stress-mediated mechanisms
BackgroundCancer is an ongoing worldwide health problem. Although chemotherapy remains the mainstay therapy for cancer, it is not always effective...
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Apoptotic and antioxidant effects in HCT-116 colorectal carcinoma cells by a spiro-acridine compound, AMTAC-06
BackgroundAcridine compounds have been described as promising anticancer agents. Previous studies showed that ( E )-1’-((4-chlorobenzylidene)amino)-5’-...
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Nano-Nutraceuticals for Health: Principles and Applications
The use of nanotechnological products is increasing steadily. In this scenario, the application of nanotechnology in food science and as a...
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Overexpressing microRNA-203 alleviates myocardial infarction via interacting with long non-coding RNA MIAT and mitochondrial coupling factor 6
Myocardial infarction (MI) is one of the leading causes of high mortality worldwide. Long non-coding RNA myocardial infarction associated transcript...
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Phytochemistry and pharmacology of natural prenylated flavonoids
Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The...
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Friedelin and 3β-Friedelinol: Pharmacological Activities
The interest in herbal medicine as a source of drug leads is being reinforced, especially for tackling challenging therapeutic areas such as...
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Empagliflozin, alone or in combination with liraglutide, limits cell death in vitro: role of oxidative stress and nitric oxide
BackgroundSodium-dependent glucose co-transporter 2 (SGLT2) inhibitor empagliflozin and glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide...
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Cytotoxic Activity of A-Modified Licorice Triterpenoid Derivatives
The cytotoxic activity of a number of A-modified derivatives of glycyrrhetic acid (GLA) and 11-deoxo- and 18,19-dehydro-GLA against conditionally...
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Protective effect of lncRNA CRNDE on myocardial cell apoptosis in heart failure by regulating HMGB1 cytoplasm translocation through PARP-1
Long non-coding RNAs (lncRNAs) are bound up with the regulation of various diseases. Here, we probed into the effect of lncRNA colorectal neoplasia...
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In Vitro Anti-melanoma Efficacy and Selectivity of Withania somnifera
Withania somnifera (L.) Dunal, Solanaceae, is a shrub known to have anti-cancer, anti-hypertensive, anti-inflammatory, and immunostimulatory...
