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Evaluation of outpatient prescription patterns of COVID-19 drugs in Iran: comparison of real practice with local therapeutic recommendations
BackgroundA comprehensive guideline named “Diagnostic Therapeutic Flow Chart for Covid-19″ (DTFC) was released by the Scientific Committee of...
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Anti-ulcerogenic Properties of Sphaeralcea angustifolia on Gastric Ulcer in Mice
Sphaeralcea angustifolia Cav. G. Don, Malvaceae, is a medicinal plant used to treat inflammatory and gastric diseases. Scopoletin, present in the...
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Evaluation of possible pharmacokinetic interaction between methotrexate and proton pump inhibitors in rats
BackgroundMethotrexate (MTX), an antifolate agent, is primarily eliminated by the kidney. Organic anion transporter 3 (OAT3) contributes to renal MTX...
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Co-Amorphous System (Paracetamol:Indomethacin): Investigations on Physical Stability and Intermolecular Interactions
To increase the performance of indomethacin (IND) by enhancing its water solubility and promoting its therapeutic efficiency, a ternary physically...
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SARS-CoV-2 therapeutics: how far do we stand from a remedy?
The SARS-CoV-2 has affected millions worldwide and has posed an immediate need for effective pharmacological interventions. Ever since the outbreak...
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Association between health literacy and medication comprehension; attitudes toward reporting adverse events in adults using over-the-counter medicines
BackgroundSelf-medication using over-the-counter (OTC) medicines is one of the effective self-care measures in dealing with daily health problems....
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Promoting generic drug usage in Japan: correlation between generic drug usage and monthly personal income
BackgroundTo reduce pharmacy-related medical expenses, it is necessary to cut drug costs, potentially by increasing generic drug usage. This study...
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Assessment of inappropriate prescribing of QT interval-prolonging drugs in end-stage renal disease patients in Jordan
BackgroundDespite the high risk of life-threatening complications due to drug-induced prolongation of the corrected QT interval (QTcP) in patients...
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Development of a Malaysian potentially inappropriate prescribing screening tool in older adults (MALPIP): a Delphi study
IntroductionPolypharmacy and potentially inappropriate medications (PIM) are common among older adults. To guide appropriate prescribing, healthcare...
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Synthesis, Analysis, and Acute Toxicity of 9-(2-diethylaminoethyl)-2-phenylimidazo[1,2-α]benzimidazole Dinitrate
The key synthetic stage (cyclization) of 9-(2-diethylaminoethyl)-2-phenylimidazo[1,2-α]benzimidazole dinitrate, which possesses antiulcer activity,...
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Recent review of COVID-19 management: diagnosis, treatment and vaccination
The idiopathic Coronavirus disease 2019 (COVID-19) pandemic outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has...
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Artesunate affords protection against aspirin-induced gastric injury by targeting oxidative stress and proinflammatory signaling
BackgroundProlonged use of aspirin, a commonly prescribed non steroidal anti-inflammatory drug, is well known to produce gastrointestinal toxicity...
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Identify potentially inappropriate medications in older adults with chronic kidney disease and deprescribe when possible
Older adults with chronic kidney disease (CKD) often receive treatment with multiple medications and are vulnerable to adverse treatment-related...
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Drug-Induced Nephrotoxicity
Drug-induced nephrotoxicity (DIN) is a relatively common adverse drug event that contributes to morbidity and increased healthcare utilisation. The...
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Intestinal drug transporters in pathological states: an overview
Emerging information suggests that gastrointestinal and systemic pathology states may affect expression and function of membrane transporters in the...
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Preventing and managing dimethyl fumarate-related adverse effects in patients with multiple sclerosis may improve adherence
Flushing and gastrointestinal effects are most common adverse effects associated with the use of oral delayed-release dimethyl fumarate in the...
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Effect of long-term administration of ranitidine, a histamine H2 receptor antagonist, on bone metabolism in young growing rats
BackgroundHistamine regulates function of osteoclasts and osteoblasts, however data regarding the influence of histamine H2 receptors antagonists on...
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Optimization of Drug Administration Dosage Regimen Considering Chronorhythms and Desynchronosis of Gastrointestinal-Tract Organs
Medicinal effects on gastrointestinal-tract (GIT) organs under normal and pathological conditions are reviewed and analyzed. It is shown that...
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Methylphenidate extended-release orally disintegrating tablets (Cotempla XR-ODT™) in attention-deficit hyperactivity disorder in children aged 6–17 years: a profile of their use
The extended-release orally disintegrating tablet (XR-ODT) formulation of methylphenidate (Cotempla XR-ODT™) is an effective and generally...
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Neonatal Safety Information Reported to the FDA During Drug Development Studies
BackgroundRelatively few neonatal drug development studies have been conducted, but an increase is expected with the enactment of the Food and Drug...