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New Estimates on the Cost of a Delay Day in Drug Development
Two frequently cited figures by clinical research insiders and observers – the cost of missing a day to generate prescription drug sales and the cost...
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Effectiveness and cost-effectiveness of combination therapy versus monotherapy in malignant melanoma
BackgroundUntil 2010, stage III or IV malignant melanoma (MM) had a poor prognosis. The discovery of immune checkpoint inhibitors (ICIs) in 2011...
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Expanding access to high-cost medicines under the Universal Health Coverage scheme in Thailand: review of current practices and recommendations
BackgroundThere has been an increasing demand to reimburse high-cost medicines, through public health insurance schemes in Thailand.
Methods ...
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Efficiency of eSource Direct Data Capture in Investigator-Initiated Clinical Trials in Oncology
BackgroundClinical trials have become larger and more complex. Thus, eSource should be used to enhance efficiency. This study aimed to evaluate the...
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Direct-to-Consumer Genetic Testing: A Comprehensive Review
Emerged in the early 2000s, direct-to-consumer (DTC) genetic testing has helped consumers access and understand their genetic information without the...
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Cost-effectiveness analysis of current non-mandatory hepatitis B vaccination coverage vs expanding coverage among healthcare workers in Ethiopia
BackgroundEthiopia is a country with high endemicity in Hepatitis B (HepB) virus infection. However, only 14% of healthcare workers (HCWs) are...
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Evidence on the Impact of Direct-to-Consumer Pharmacogenetic Testing
Pharmacogenomics, also known as pharmacogenetics, is a practice and study that combines two long-standing disciplines, which are pharmacology and...
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Cost-effectiveness analysis of budesonide/formoterol (Symbicort®) as needed for mild asthma in Malaysia
BackgroundBudesonide/formoterol (Symbicort ® ) as needed (PRN) is effective for the prevention of severe exacerbations in mild asthma.
Objective ...
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Act quickly to manage bleeding in patients taking direct oral anticoagulants
Direct oral anticoagulants (DOACs) are increasingly preferred anticoagulation options, with a lower risk of intracranial haemorrhage versus warfarin....
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Medication errors associated with direct-acting oral anticoagulants: analysis of data from national pharmacovigilance and local incidents reporting databases
BackgroundFor more than a decade, direct oral anticoagulants (DOACs) have been approved in clinical practice for multiple indications such as stroke...
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Using cost-effectiveness analysis to support policy change: varenicline and nicotine replacement therapy for smoking cessation in Jordan
BackgroundSmoking cessation pharmacotherapies (SCPs) have been established as cost-effective for the treatment of tobacco use disorder across a...
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Application of the Kuenz–Leuenberger Equation as a Predictive Model of the Direct Tablet Compression Process
Mathematical models, the most widely applied of which are the Heckel and Kawakita models, are used in modern research on the compression process to...
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The Impact of Serialisation on Operational Efficiency and Productivity in Irish Pharmaceutical Sites
Technology enabling drug serialisation technology was introduced by regulators to enhance security in pharmaceutical supply chain and protect drugs...
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A Review of the Medical Challenges of Using Direct Oral Anticoagulants in Real-World Practice
Clinical guidelines for management of non-valvular atrial fibrillation or venous thromboembolism currently recommend direct oral anticoagulants as...
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Analysis of pharmaceutical inventory management based on ABC-VEN analysis in Rwanda: a case study of Nyamagabe district
BackgroundPharmaceuticals account for a large portion of healthcare spending in healthcare organizations. Their effective inventory management is...
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Pharmacist intervention amid the coronavirus disease 2019 (COVID-19) pandemic: from direct patient care to telemedicine
IntroductionThe coronavirus disease (COVID-19) pandemic has placed enormous pressures on the Canadian healthcare system. Patients are expected to...
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Economic Evidence for Pharmacist Prescribing in Community Pharmacy
The effectiveness of pharmacist interventions is supported by high-level evidence from around the world. Such effectiveness combined with high levels...
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The PHASTER Study: Economic and Organizational Impact of Subcutaneous (SC) Pertuzumab and Trastuzumab Fixed-Dose Combination (PH FDC SC) for Treatment of HER2+ Breast Cancer Patients
BackgroundThis study evaluated the impact of using the subcutaneous fixed-dose combination of pertuzumab + trastuzumab (PH FDC SC) compared with...
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Tenders for the Procurement of Medical Devices: Adapting Cost-Effectiveness Rules to the Requirements of the European Public Procurement Directive
Background:In evaluating 3 or more comparators, pharmacoeconomic analyses can be improved by using the methodology of net monetary benefit (NMB) as...
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Access to a novel first-line single-tablet HIV antiretroviral regimen in Affordable Care Act Marketplace plans, 2018–2020
BackgroundA pillar of the United States’ Ending the HIV Epidemic (EHE) initiative is to rapidly provide antiretroviral therapy (ART) in order to...
