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Current Strategies in Development of New Chromone Derivatives with Diversified Pharmacological Activities: A Review
Chromone derivatives possess a spectrum of biological activities. Chromone has been recognized as a privileged structure for new drug invention and...
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Synthesis of Natural and Biologically Active Quinoxaline Analogs
Reactions of quinoxalines and quinoxalin-2-ones with C -nucleophiles under acid-catalysis conditions gave products from nucleophilic substitution of...
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Synthesis of New Betulonic Acid Conjugates with 2-Perfluoroacylcycloalkane-1,3-Diones Using Polymethylenediamine Linkers
New betulonic acid conjugates were synthesized in high yields by reacting 2-perfluoroacyl-3-chloro-2-cycloalken-1-ones, which were prepared by...
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Biotransformation of Active Methylene Compounds by Saccharomyces cerevisiae
The biotransformation of several activated CH-acid compounds was examined using Saccharomyces cerevisiae as a biocatalyst. Alkylation–hydroxylation...
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Efficient Synthesis and Antibacterial Evaluation of a Series of Pyrazolylbiscoumarin and Pyrazolylxanthenedione Derivatives
Efficient synthesis of a series of pyrazolylbiscoumarin ( 4a – 4e ) and pyrazolylxanthenedione derivatives ( 5a – 5e ) is described. The structures of...
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New Opportunities for the Synthesis of Quinoxaline-Substituted Heterocyclic and Aryl Moieties
6.7-Difluoroquinoxaline ( I ) reacted with dimedone, indandione, and 3-methyl-1-phenylpyrazol-5-one in DMSO solution in the presence of acid to form...
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Synthesis, Characterization, and In Vitro Antimicrobial and Antifungal Activity of Novel Acridines
Novel acridines (4a – 4l) were synthesized by reaction of tetraketones (3a, 3b) and aromatic amines. The structures of compounds were characterized...
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A simple means of preparing quinoxaline derivatives: direct introduction of C-nucleophiles into the quinoxaline nucleus by substituting a hydrogen atom
Unsubstituted quinoxaline (I) reacts with dimedone, indanedione, and 1-phenyl-3-methylpyrazol-5-one in dimethylsulfoxide in the presence of acid to...
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Heterocyclization of 3-aminocamphor and 3-aminoisoborneol derivatives with cyclic β-diketones and formaldehyde. Synthesis of optically active 1,2,3,4-tetrahydroquinoline derivatives with terpene substituents
Spirocyclic 1,2,3,4-tetrahydroquinoline derivatives were prepared in quantitative yield by three-component condensation of dimedone or Meldrum’s acid...
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Chemical modification of plant alkaloids. 6. T-reactions of anabasine derivatives
T-reactions of anabasine derivatives were performed for the first time. Condensation of 5-nitro-2-[2-(3pyridyl)piperidino]benzaldehyde with...
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Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis
Acridine derivatives constitute a class of compounds that are being intensively studied as potential anticancer drugs. Acridines are well-known for...
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Synthesis of new pyrazolo[1,5-a]pyrimidines
A series of condensed heterocycles containing the pyrazolo[1,5- a ]pyrimidine moiety were synthesized from 5-amino-3-methyl-4-phenylpyrazole. The...
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Specific features of the interaction of fervenulin and its 4-N-oxide with C-nucleophiles: Structural and spectroscopic characteristics of molecular complexes and covalent adducts with indoles
Experimental data on the chemical transformations of the antibiotic fervenulin and its analogs have been analyzed and compared to the results of...
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Structure and spectral characteristics of fervenulin and 2-methylfervenulin-3-one 4-N-oxides: Features of the transformations of fervenulin-3-one and its 4-N-oxide with C-nucleophiles
The structures of crystalline fervenulin, 2-methylfervenulin-3-one (MSD-92), and their 4-N-oxides were studied using x-ray diffraction and 1 H and 13 C...
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Reaction of Long-Chain Vanillyl Esters with CH-Acids and 2-Naphthylamine
The previously unknown 4-(alkyl-11-oxo-7,8,9,10,11,12-hexahydrobenzo[a]acridin-12-yl)- and...