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Synthesis of β2-Agonist Metabolites of 2-(4-Amino-3,5-Dichlorophenyl)-2-(Alkylamino)Ethanols and their Excretion with Urine in Comparison to the Initial Compounds
Metabolites of β2-agonists 2-(4-amino-3,5-dichlorophenyl)-2-(alkylamino)ethanols, derivatives of hippuric and mandelic acids, were synthesized. The...
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Synthesis and Pharmacokinetics of 2-(4-amino-3,5-dichlorophenyl)-2-(alkylamino)ethanols - Structural Isomers of β2 Agonists Clenproperol and Clenpenterol
Methods for the synthesis of 2-(4-amino-3,5-dichlorophenyl)-2-(isopropylamino)ethanol and 2-(4-amino-3,5-dichlorophenyl)-2-( tert -amylamino)ethanol,...
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Cytoprotection Activity Evaluation of (E)-3-(3,4-Dichlorophenyl)-1-(3,4-Dihydroxyphenyl)- Prop-2-En-1-One as a New Antioxidant Against H2O2-Induced Oxidative Damage in PC12 Cells
Scavenging reactive oxygen species (ROS) by antioxidants is an important therapy to neurodegenerative diseases. In this work, a new chalcone compound...
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Improved Efficient Synthesis of the Transthyretin Amyloid Fibril Inhibitor Tafamidis
Aconvenient and efficient route for the preparation of Tafamidis, the first and only medicine for patients with either wild-type or hereditary...
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Synthesis, Pharmacological Evaluation and Molecular Docking Studies of N-[2-(1H-indol-3-yl)Acetyl]Arylsulfonohydrazides
Synthesis of heterocyclic compounds encompassing multiple functionalities and their biological screening is the most adapted strategy in the world...
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Sigma receptors and neurological disorders
Sigma receptors were identified relatively recently, and their presence has been confirmed in the central nervous system and peripheral organs....
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Design, Synthesis and In Vivo Anxiolytic Activity of Novel Flavonoids
Worldwide millions of peoples are suffering from psychological disorders of which anxiety is one of the major and common problems. Knowing...
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Synthesis of Imidazole-Thiazole Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities
In this study, the synthesis of the planned compounds was carried out in two steps. In the first step, 1-methylimidazole-2-carbaldehyde compound was...
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Studies on the Potential Vehicles (Co-Vehicles) for Formulating Intranasal Solution of Lamotrigine
Lamotrigine, an antiepileptic agent belonging to class II of the Biopharmaceutical Classification System (BCS), has linear pharmacokinetics and wide...
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Synthesis and Anti-Inflammatory Activity of N,6-Diaryl-4-Methyl-2-Thioxo-1,2,3,6-Tetrahydropyrimidine-5-Carboxamides
Previously unreported N ,6-Diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides were synthesized by reacting acetoacetanilides with a...
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Formulation and Evaluation of Tamarind Seed Polysaccharide Gel for the Controlled Delivery of Aceclofenac
The purpose of this study was to develop a transdermal gel with the addition of different polymer ratios that incorporates 1.0 %w/w aceclofenac to...
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Piperazine Heterocycles as Potential Anticancer Agents: A Review
Cancer is a rapid, out of control, and proliferation pathology of ordinary cells, which has become one of the most infamous and aggressive health...
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Synthesis and Investigation of Carbonic Anhydrase I and II Activity of Dihydrobenzo[h]Quinazolin-2-yl Thiourea Compounds
Thirteen novel compounds in a series of dihydrobenzo[ h ]quinazolin-2-yl thiourea compounds ( 7a–m ) were synthesized and characterized using FT-IR, 1 H, 13 ...
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Evaluation of Cytotoxic Activity of New Benzimidazole-Piperazine Hybrids Against Human MCF-7 and A549 Cancer Cells
A series of benzimidazole-piperazine hybrids ( 14 – 37 ) were designed, synthesized and evaluated for their cytotoxic activity against human lung...
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Synthesis and Antifungal Activity Evaluation of 1-(2-Benzyloxy-2-Phenylethyl)-1,2,3-Triazole Miconazole Analogs
Aseries of 1-(2-aryloxy-2-phenylethyl)-1,2,3-triazole derivatives (Miconazole analogs) was obtained via copper catalyzed azide-alkyne cycloaddition...
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Chemistry and Biological Activity of Mustard Oil: Therapeutic Benefits and Risk to Healthcare
Over the years, extensive research on mustard oil has revealed the presence of isothiocyanates as pungent toxic compounds and erucic acids as...
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Synthesis of novel spirooxindole-pyrrolidines and evaluation of their cytotoxic activity
BackgroundA variety of spirooxindoles have demonstrated cytotoxic activity toward several cancer cell lines. This study investigates the cytotoxicity...
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Current Advancements for New Drug Discovery Against Dengue Virus: A Review (2015 – 2020)
Dengue fever is a viral ailment mostly found in tropical and sub-tropical communities. Dengue fever is spread by the mosquito Aedes aegypti....
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Antioxidant Role of Carvacrol Against Hepatotoxicity and Nephrotoxicity Induced by Propiconazole in Rats
Propiconazole is a broadly used fungicide that leaves residues in food and water causing severe dangerous effects on humans and animals. The current...
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Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors
BackgroundSince brain neurotransmitter levels are associated with the pathology of various neurodegenerative diseases like Parkinson and Alzheimer,...
