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Targeting cytokines and signaling molecules related to immune pathways in atopic dermatitis: therapeutic implications and challenges
Although atopic dermatitis (AD) is primarily a Th2-driven disease, it shows high heterogeneity with additional variable contributions of the Th22,...
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Co-Administration of Polyamines with Rutin and Metformin Ameliorates Streptozotocin-Induced Diabetes: Possible Involvement of Antioxidants, Inflammatory Cytokines, and Biochemical Paradigms
The present investigation was undertaken to study the role of polyamines and rutin in combination with metformin in the streptozotocin-induced...
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FNF-12, a novel benzylidene-chromanone derivative, attenuates inflammatory response in in vitro and in vivo asthma models mediated by M2-related Th2 cytokines via MAPK and NF-kB signaling
Background and aimThis study evaluates a novel benzylidene-chromanone derivative, FNF-12, for efficacy in in vitro and in vivo asthma models.
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Adjuvant Properties of Cytokines in Vaccination (Review)
Vaccinal prophylaxis is the most effective way to reduce incidence rates. However, the immune response develo** after injection of most inactivated...
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Pro-inflammatory cytokines, but not brain- and extracellular matrix-derived proteins, are increased in the plasma following electrically induced kindling of seizures
BackgroundThe aim of the study was to evaluate the brain-derived proteins, extracellular matrix-derived protein and cytokines as potential peripheral...
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In Vitro Study of the Cytotoxic and Immunotropic Effects of Molnupiravir and Favipiravir
The effects of the antiviral drugs molnupiravir and favipiravir on the viability of human embryonic lung cells and the production of cytokines by...
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A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice
BackgroundIA-0130 is a derivative of 3-(1,3-diarylallylidene)oxindoles, which is a selective estrogen receptor modulator (SERM). A previous study...
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Diosmetin Alleviates Ovalbumin-Induced Nasal Inflammation by Regulating the SIRT1/NF-κB Signaling in Mouse Models of Allergic Rhinitis
Diosmetin is a flavonoid compound with various pharmacological activities, which plays a vital role in alleviating the development of asthma and...
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New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study
BackgroundChronic inflammation in the course of inflammatory bowel disease may result in colon cancer, or colitis-associated colorectal cancer...
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The Effect of Aerobic Training and Octopamine on Inflammatory Signaling Pathway in White Adipose Tissue of Rats Poisoned with Deep-Fried Oil
Increasing fat and poor diet impair the immune system by suppressing macrophages, but the beneficial effects of aerobic training (AT) and octopamine...
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Glycyrrhizic Acid Reverses Neurological Deficits by Attenuating Rac1-STAT3 Signalling-Mediated Neuroinflammation in a Mouse Model of Neonatal Hypoxic-Ischemic Encephalopathy
The protective anti-inflammatory effects of glycyrrhizic acid have been demonstrated in many diseases. This study aimed to explore the...
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Therapeutic implication of Sonic Hedgehog as a potential modulator in ischemic injury
Sonic Hedgehog (SHh) is a homology protein that is involved in the modeling and development of embryonic tissues. As SHh plays both protective and...
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Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways
Neuroinflammation is a specific or nonspecific immunological reaction in the central nervous system that is induced by microglia activation....
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Influence of Urolithin a on Cytokine Production by Various Cancer Cell Lines
Urolithin A is a polyphenolic metabolite of ellagic acid and ellagitannins that is produced by the intestinal microbiota and has a higher...
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Effect of Ellipticine in Glucocorticoid-Induced Osteoporosis: In Silico and In Vivo Analyses
Glucocorticoids cause secondary osteoporosis, which leads to considerable morbidity from fractures. The antiosteoporosis activity of ellipticine...
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Isoacteoside Protects Against Sepsis-Induced Acute Lung Injury by Regulating the SIRT1/Nrf2/NF-κB/NLRP3 Signaling Pathways
Sepsis-related acute lung injury is a severe inflammatory pulmonary disorder. Isoacteoside is a phenylethanoid derived from Monochasma savatieri ...
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A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma
BackgroundPegylated arginine deiminase (ADI-PEG20; pegargiminase) depletes arginine and improves survival outcomes for patients with...
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Anti-asthmatic Activity of Liriodendrin Against Ovalbumin-Induced Asthma in Mice via Attenuating TNF-α
Asthma is a serious hypersensitive allergic manifestation and frequently becomes life-threatening if not managed well in time. However, the...
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The Prophylactic Effects of Isosteviol Aerosol Inhalation on Bronchial Asthma in Mice
The diterpenoid isosteviol is one of the stevia derivatives that have reported various activities . In mice inhaling isosteviol, OVA- and ACh-induced...
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Distinctive role of inflammation in tissue repair and regeneration
Inflammation is an essential host defense mechanism in response to microbial infection and tissue injury. In addition to its well-established role in...
