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A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma
BackgroundPegylated arginine deiminase (ADI-PEG20; pegargiminase) depletes arginine and improves survival outcomes for patients with...
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Influence of Urolithin a on Cytokine Production by Various Cancer Cell Lines
Urolithin A is a polyphenolic metabolite of ellagic acid and ellagitannins that is produced by the intestinal microbiota and has a higher...
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The association of the quality of sleep with proinflammatory cytokine profile in inflammatory bowel disease patients
BackgroundThe role of circadian rhythm abnormalities in patients with inflammatory bowel disease (IBD) remains relatively unknown. The aim of this...
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Essential phospholipids impact cytokine secretion and alter lipid-metabolizing enzymes in human hepatocyte cell lines
BackgroundEssential phospholipids (EPL) are hepatoprotective.
MethodsThe effects on interleukin (IL)-6 and -8 secretion and on certain...
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The effect of tocilizumab on cytokine release syndrome in COVID-19 patients
BackgroundThis study was aimed to assess the efficacy and safety of tocilizumab (TCZ) and to investigate the factors related to the progress and...
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Cannabidiol prevents lipopolysaccharide-induced sickness behavior and alters cytokine and neurotrophic factor levels in the brain
BackgroundMajor depressive disorder (MDD) affects millions of people worldwide. While the exact pathogenesis is yet to be elucidated, the role of...
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Role of specialized pro-resolving lipid mediators and their receptors in virus infection: a promising therapeutic strategy for SARS-CoV-2 cytokine storm
Unexpected viral infections outbreaks, significantly affect human health, leading to increased mortality and life disruption. Among them is the...
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Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins
Innate immunity is one of the most ancient and conserved aspect of the immune system. It is responsible for an anti-infective response and has been...
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Diosmetin Alleviates Ovalbumin-Induced Nasal Inflammation by Regulating the SIRT1/NF-κB Signaling in Mouse Models of Allergic Rhinitis
Diosmetin is a flavonoid compound with various pharmacological activities, which plays a vital role in alleviating the development of asthma and...
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Implications of inflammatory cell death-PANoptosis in health and disease
Regulated cell death (RCD) pathways, such as pyroptosis, apoptosis, and necroptosis, are essential for maintaining the body’s balance, defending...
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Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain
BackgroundTreatment of neuropathic pain is still challenging. Recent studies have suggested that dorsal root ganglia (DRG), which carry sensory...
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Photodynamic Anti-Inflammatory Activity of Porphyrin Derivative on In-Vitro Activated Macrophages
Porphyrin derivatives have been known for their photodynamic therapy (PDT) application potential. In the present work, we have studied an asymmetric...
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Nootropic Effects of 7-Isoprenyloxycoumarin and Herniarin from Tagetes lucida on Lipopolysaccharide-Induced Neuroinflammation
Tagetes lucida Cav., Asteraceae, is an essential cultural plant that is traditionally used to treat diseases involving inflammatory processes and is...
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Agonisten und Antagonisten von membranständigen Rezeptoren
Die Versendung und Weiterleitung von Informationen zwischen Zellen wird von Botenstoffen übernommen. Diese können so klein sein wie einzelne Ionen,...
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Targeting cytokines and signaling molecules related to immune pathways in atopic dermatitis: therapeutic implications and challenges
Although atopic dermatitis (AD) is primarily a Th2-driven disease, it shows high heterogeneity with additional variable contributions of the Th22,...
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Immunomodulating and Anti-parasitary Mechanisms of Plant Products in the Treatment of Schistosomiasis
In this review, original research articles on plant extracts, essential oils, and their bioactive compounds with therapeutic activity against Schistoso...
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Nanoemulsion Improves the Anti-inflammatory Activity of Carvacrol upon Oral Administration
Carvacrol is the main phenolic monoterpene isolated from the essential oils of plants from the genus Origanum L., Lamiaceae. Carvacrol has several...
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Treat psoriasis with traditional and novel topical therapies
The mainstay topical treatments for psoriasis are corticosteroids and/or vitamin D analogues, with retinoids, calcineurin inhibitors, salicylic acid...
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Pristimerin: Natural Occurrence, Biosynthesis, Pharmacology, and Pharmacokinetics
Pristimerin is a naturally occurring triterpenoid originally isolated from plant members of the genus Pristimera Miers, Celastraceae, and can be also...
