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Metabolism by Rhizobacteria of Abscisic Acid Deuterated in the Cyclohexene Part
The required amount of abscisic acid containing 4 – 5 D atoms ([ 2 H]ABA) in the cyclohexene fragment of the molecule was produced via isotope exchange...
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NMR Spectroscopy Study of Enol–Enol Tautomerism of Nitisinone in Solutions
The structure of nitisinone (β, β′-triketone reversible inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase) in various protic and aprotic...
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Bioactive natural products from the genus Salinospora: a review
Actinomycetes are an important source for bioactive secondary metabolites. Among them, the genus Salinispora is one of the first salt obligatory...
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Alternative Synthesis of Cobimetinib
A novel approach for synthesis of Cobimetinib was reported, avoiding usage of a strong base in any of the steps with a chiral substrate. An efficient...
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From Relative to Absolute Stereochemistry of Secondary Metabolites: Applications in Plant Chemistry
Structural elucidation of specialized metabolites or natural plant products, especially the stereochemical features of chiral bioactive metabolites,...
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Synthetic Transformations of Higher Terpenoids. 37. Synthesis and Cytotoxicity of 4-(Oxazol-2-Yl)-18-Norisopimaranes
The synthesis and properties of tricyclic diterpenoids containing a C-4 functionalized oxazole ring are reported. The reaction of...
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Hydroboration–Oxidation of Terpenoids in Targeted Syntheses of Low-Molecular-Mass Bioregulators
Examples of hydroboration–oxidation of natural mono-, sesqui-, di-, and triterpenoids are reviewed. Diborane, BH 3 ·THF, BH 3 ·Me 2 S, disiamylborane,...
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Chromone Alkaloids: Structural Features, Distribution in Nature, and Biological Activity
Structural data of chromone alkaloids and antibiotics related to them that were isolated from natural sources up to 2017 are systematized in this...
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Hydroboration by Diborane of Methyl Abietate
Hydroboration-oxidation of methyl abietate by diborane in THF occurred preferentially at the sterically unhindered β -side of the molecule without...
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Complete Assignment of NMR Data of Alterporriol I
Pure alterporriol I, together with 13 known altersolanol-type compounds and alterporriols, was isolated from a culture broth of the marine-derived...
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Synthetic Transformations of Higher Terpenoids. 36.* Synthesis of 13-(Oxazol-5-Yl)-15,16-Bisnorisopimaranes
The conditions for oxidizing methyl isopimarate to the 15-oxo-15,16-dihydroisopimarate were studied. The latter was used for one-pot syntheses of...
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Chemical diversity and activity profiles of HIV-1 reverse transcriptase inhibitors from plants
Current challenges to antiretroviral therapy have opened new vistas in the search for novel drugs from natural products. This review focusses on...
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Two New Sesquiterpene Lactones from Artemisia halophila
Two new eudesmane-type sesquiterpene lactones were isolated by column chromatography from the CHCl 3 extract of the endemic plant Artemisia halophila ....
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Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin
Background5,5-Diphenylhydantoin (Phenytoin) is a well-known anticonvulsant and antiarrhythmic drug which may cause unwanted side effects. In order to...
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Sesquiterpenoid Glycosides from the Fruits of Chaenomeles speciosa
A new sesquiterpenoid glycoside, called speciosaoside A (
1 ), and a known sesquiterpenoid glycoside, (1′ R ,3′ R ,5′ R ,8′ S )-epi-dihydrophaseic acid...
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Synthesis, Characterization, and In Vitro Antimicrobial and Antifungal Activity of Novel Acridines
Novel acridines (4a – 4l) were synthesized by reaction of tetraketones (3a, 3b) and aromatic amines. The structures of compounds were characterized...
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Ozonolysis of Unsaturated Compounds in the Synthesis of Insect Pheromones and Juvenoids
Research from the last 20 years on the use of ozonolysis of cyclic and acyclic mono- and dienes and aromatic compounds in various steps of the total...
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Substrate Oxidation by Cytochrome P450 Enzymes
Cytochrome P450 enzymes catalyze a broad diversity of reactions, including well-established transformations such as carbon and nitrogen...
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Constituents from Zhuyeqing Liquor with hepatoprotective effect on alcohol-induced HepaG 2 toxicity
An unprecedented new skeleton compound (1 R , 10 R , 11 S )-10,11-dimethyl-4-formyl-2,9-dioxa-bicyclo [5.4.0] undeca-4,6-dien-3-one ( 1 ), monoterpenoids and...
