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Toxicological, Antidiarrhoeal and Antispasmodic Activities of Syzygium myrtifolium
Syzygium myrtifolium Walp. ( Syzygium campanulatum Korth), Myrtaceae, is locally known as “Kelat paya” in Malaysia. Traditionally, it is used as a...
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Phytochemical Small Molecules as Potential Anti-angiogenesis Targeted Therapy for Triple-Negative Breast Cancer
Triple-negative breast cancer stands out as the most formidable subtype of breast cancer. Currently, there is a lack of specialized treatments for...
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Autophagy induced by cardamonin is associated with mTORC1 inhibition in SKOV3 cells
BackgroundThe mammalian target of rapamycin (mTOR) integrates energy level to modulate cell proliferation and autophagy. Cardamonin exhibits...
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Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms
In addition to the typical respiratory manifestations, various disorders including involvement of the nerve system have been detected in COVID-19...
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Steroids from Dendronephthya mucronata and Their Inhibitory Effects on Lipopolysaccharide-Induced No Formation in RAW264.7 Cells
Four pregnane-type steroids including the new compound 5- α -pregn-20-en-3,6-dione ( 1 ) and two known cholestane-type steroids were isolated from the...
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Protective effect of cardamonin against acetic acid-induced ulcerative colitis in rats
BackgroundUlcerative colitis (UC) is an inflammatory bowel disease with significant morbidity. Cardamonin is a natural chalcone derivative with...
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Cardiotoxicity linked to anticancer agents and cardioprotective strategy
Chemotherapy is a main treatment for cancer, and it benefits patients by controlling cancer relapse and metastasis, thereby leading to an increase in...
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Phthalides and Other Metabolites from Roots of Ligusticum wallichii
A new phthalide that was identified using NMR and mass spectral data as (±)-3-methoxysedanenolide ( 1 ) and the nine known compounds sedanenolide ( 2 ),...
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Phytochemistry and antimicrobial activity of Campomanesia adamantium
Campomanesia adamantium (Cambess.) O. Berg., Myrtaceae, is a plant popularly used for its antiinflammatory, anti-diarrhoeal and urinary antiseptic...
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Antiproliferative effects of pinostrobin and 5,6-dehydrokavain isolated from leaves of Alpinia zerumbet
Natural products are a major source of drugs for the treatment of cancer. The species Alpinia zerumbet (Pers.) B.L. Burtt amp; R.M. Sm,...
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Anti-inflammatory, and antinociceptive effects of Campomanesia adamantium microencapsulated pulp
Guavira fruits have antimicrobial, antioxidant, antinociceptive, and anti-inflammatory activities. Spray drying has been widely used in the food...
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The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment
Nrf2 acts as a sensor of oxidative or electrophilic stress and prevents genome instability. The activation of Nrf2 signaling induces ARE-dependent...
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Flavonoids as Potential Immunosuppressants Affecting Intracellular Signaling Pathways (a Review)
Flavonoids are a large group of polyphenolic compounds that are present in almost all higher plants. Recent research demonstrated a wide range of...
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Pharmacokinetic interactions of clopidogrel with quercetin, telmisartan, and cyclosporine A in rats and dogs
In this study, we investigated pharmacokinetic drug interactions of clopidogrel with P-gp inhibitors in rats and dogs. Following the oral...
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Structural requirements of 2′,4′,6′-tris(methoxymethoxy) chalcone derivatives for anti-inflammatory activity: The importance of a 2′-hydroxy moiety
Butein, a natural chalcone, has anti-inflammatory and hepatoprotective activity. One synthetic derivative of butein,...
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