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Synthesis and Antinociceptive, Anthelmintic, and Larvicidal Activities of 4-(3,3-Dimethyl-3,4-Dihydroisoquinolin-1-Ylthio)Aniline Hydrochlorides
Ritter cyclocondensation of 3,4-(R) 2 -dimethylbenzylcarbinols with thiocyanatoanilines was used to obtain 4-[6,7-(R) 2 -3,3-dimethyl-3,4-dihydroisoquinol...
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Synthesis and Biological Activity of 2-(3,3-Dimethyl-6,7-Diethoxy-3,4-Dihydroisoquinolin-1-yl)Carboxylic Acid Hydrochlorides and Their Benzo[f]-Analogs
Ritter reactions of 1-(3,4-diethoxyphenyl)-2-methylpropanol-2 with 2-alkylcyanoacetamides (alkyl = Et, n -Pr, n -Bu, n -Am, i -Am) were used to...
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Microbial Transformation of Azorellane and Mulinane Diterpenoids
Microbial transformation is an alternate strategy to obtain novel derivatives from natural products using whole cells or enzymes because of their...
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Synthesis of 3,3-Dimethyl- and 3,3-Diethyl-Substituted 2-(3,4-Dihydroisoquinolin-1-yl)Carboxylic Acid Amide Hydrochlorides and Their Anti-Arrhythmic, Hemostatic, Anthelmintic, and Larvicidal Activity
Series of 3,3-dimethyl- and 3,3-diethyl-substituted 2-R-(3,4-dihydroisoquinolin-1-yl)acetamides were synthesized via Ritter reactions of...
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Study of the Immunomodulatory Effect of Polysaccharides Isolated from Seeds of Turnip BRASSICA RAPA
The goal of this study was an evaluation of the immunomodulatory effect of polysaccharides isolated from the seeds of Brassica rapa . Apolysaccharide...
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Recent progress in biologically active indole hybrids: a mini review
The indole moiety is one of the most widespread heterocycles found in both natural products and biological systems. Indoles have important biological...
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Synthesis and Analgesic Activity of 3,3-Dialkyl-Substituted Drotaverine Analogs
Ritter reactions of 3,4-(R 1 ) 2 -benzylcyanides with 1,1-(R 2 ) 2 -2-[3,4-(R 3 ) 2 -phenyl]ethanols synthesized 1-[3,4-(R 1 ) 2 -benzyl]-3,3-(R 2 ) 2 -6,7-(R 3 ) 2 -3,4-dihy...
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Synthesis, Anti-Arrhythmic, Hemostatic, Anthelmintic, and Larvicidal Activity of 2-(3-spiro-cycloalkyl-3,4-dihydroisoquinolin-1-yl)-Carboxylic Acid Amide Hydrochlorides
A series of nine 2-(3-spiro-cycloalkyl-3,4-dihydroisoquinolin-1-yl)carboxylic acid amide hydrochlorides were synthesized using Ritter cyclization of...
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New Cycloartane Glycoside from Astragalus mucidus
A new glycoside was isolated from the aerial part of Astragalus mucidus . Its chemical structure was characterized as a cycloartane triterpenoid using...
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Elucidation of the Anticancer Potential of Selected Citrus Flavonoids Against NEDD4-1 in Breast Cancer
Neural precursor cell expressed developmentally downregulated protein 4 is commonly reported to be overexpressed by regulating developmental control,...
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Synthesis and Antiarrhythmic, Hemostatic, Anthelmintic, and Larvicidal Activity of (3,3-Dialkyl-6,7-Diethoxy-3,4-Dihydroisoquinolin-1(2H)-Ylidene)Acetamide Hydrochlorides
A series of (3,3-dialkyl-6,7-diethoxy-3,4-dihydroisoquinolin-1(2 H )-ylidene)acetamide hydrochlorides were synthesized via Ritter cyclocondensation of...
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Effects of Glycoalkaloids from Solanum lycocarpum on Genomic Instability
Solamargine and solasonine are the main glycoalkaloid metabolites found in fruits of Solanum lycocarpum A. St.-Hil., Solanaceae, a native plant of...
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Synthesis and Antiarrhythmic and Hemostatic Activity of [3,3-Dialkyl-3, 4-Dihydroisoquinolin-1(2H )-Ylidene]-N-Alkylacetamides
[3,3-Dialkyl-3,4-dihydroisoqinolin-1(2 H )-ylidene]-N-alkylacetamides were synthesized by reacting dialkylbenzylcarbinols with N-alkylcyanoacetamides....
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From Relative to Absolute Stereochemistry of Secondary Metabolites: Applications in Plant Chemistry
Structural elucidation of specialized metabolites or natural plant products, especially the stereochemical features of chiral bioactive metabolites,...
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Synthesis and Analgesic and Anticonvulsant Activity of 4-Substituted 2,2-Dialkyl-1,2-Dihydrobenzo [f] Isoquinolinium Chlorides
Ritter cyclocondensation of 2-(1-naphthyl)-1,1-(R 1 ) 2 -ethanols [R 1 = Me, 2R 1 = (CH 2 ) 4 ] with nitriles of general formula R2CN (acetonitrile,...
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Absolute Stereochemistry of Antifungal Limonene-1,2-diols from Lippia rubella
From the active dichloromethane-soluble extract of Lippia rubella (Moldenke) T.R.S. Silva & Salimena, Verbenaceae (MIC = 78 μg/ml against Cryptococcus...
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Synthesis and Analgesic and Anti-Inflammatory Activities of (3,3-Dipropyl-6,7-Dimethoxy-3,4-Dihydroisoquinolin-1(2H)-Ylidene)-Acetamide Hydrochlorides
Cyclocondensation of 4-(3,4-dimethoxybenzyl)heptan-4-ol with N-substituted cyanoacetamide was used to synthesize...
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A Novel Normethylfriedelane-Type Isoprenoid from Syzygium guineense Stem Bark
Isolated from the n-hexane soluble fraction of the chloroform extract of Syzygium guineense stem bark were two friedelane-type isoprenoids,...
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Synthesis and Biological Activity of 1-Chloromethyl- and 1-Dichloromethyl-3,3-Dialkyl-3,4-Dihydroisoquinolinium Chlorides
1-Chloromethyl- and 1-dichloromethyl-3,3-dialkyl-3,4-dihydroisoquinolines were synthesized via cyclo-condensation of dialkylbenzylcarbinols with...
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Potential phytochemicals in the prevention and treatment of esophagus cancer: A green therapeutic approach
Globally, esophagus cancer (EC) is one of the most frequently reported malignancies and leading cause of deaths. Currently, different treatment...