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Sotalol does not interfere with the antielectroshock action of selected second-generation antiepileptic drugs in mice
BackgroundDue to blocking β-receptors, and potassium KCNH2 channels, sotalol may influence seizure phenomena. In the previous study, we have shown...
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Polygonogram with isobolographic synergy for three-drug combinations of phenobarbital with second-generation antiepileptic drugs in the tonic–clonic seizure model in mice
BackgroundCombination therapy consisting of two or more antiepileptic drugs (AEDs) is usually prescribed for patients with refractory epilepsy. The...
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Studies on the Potential Vehicles (Co-Vehicles) for Formulating Intranasal Solution of Lamotrigine
Lamotrigine, an antiepileptic agent belonging to class II of the Biopharmaceutical Classification System (BCS), has linear pharmacokinetics and wide...
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Anticonvulsant and neurotoxic effects of a novel 1,2,4-triazole-3-thione derivative (TPF-34) and its isobolographic interaction profile with classical antiepileptic drugs in mice
BackgroundAnticonvulsant and acute toxic effects of 5-[(3-fluorophenyl)ethyl]-4-( n -hexyl)-2,4-dihydro-3 H -1,2,4-triazole-3-thione (TPF-34)—a...
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Revisiting clinical practice in therapeutic drug monitoring of first-generation antiepileptic drugs
Due to the complex and diverse nature of epilepsy and antiepileptic drugs (AEDs), the implementation of therapeutic drug monitoring (TDM) can...
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Teratogenic potential of third-generation antiepileptic drugs: Current status and research needs
The aim of this review was to scrutinize the current literature available on teratogenic safety of third-generation antiepileptic drugs (TGAEDs)...
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Influence of salbutamol on the anticonvulsant potency of the antiepileptic drugs in the maximal electroshock-induced seizures in mice
Backgroundβ 2 -Adrenergic receptor agonists are widely used agents in the treatment of asthma or preterm labor. Since prevalence of asthma was shown...
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Risk of Cleft Lip and/or Palate Associated With Antiepileptic Drugs: Postmarketing Safety Signal Detection and Evaluation of Information Presented to Prescribers and Patients
BackgroundThe aim was to analyze safety data associated with the maternal use of antiepileptic drugs in pregnancy and to assess the risk of cleft lip...
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Effect of caffeine on the anticonvulsant action of pregabalin against electroconvulsions in mice
BackgroundExperimental data indicate that caffeine (CAF) can reduce the anticonvulsant activity of antiepileptic drugs (AEDs) in animal models of...
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Effect of Bumetanide Administration on the Pharmacoresistant Seizure to Lamotrigine in Electrical Amygdala Kindled Rats
In recent decades, 30 – 40 percent of epilepsy patients did not get relief from seizures by antiepileptic medications. In the present study, the...
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DISCUSSION OF HERBAL DRUGS BASED ON THE BIOGENETIC CLASSIFICATION OF THEIR MAIN ACTIVE COMPONENTS
Honey is prepared by honey-bees (Apis mellifera) from the nectar and honeydew of flowers. After chemical conversion by the gastric juices in the...
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Role of clinical pharmacists in epilepsy management at a general hospital in Vietnam: a before-and-after study
BackgroundClinical pharmacists have an important role in inter-professional healthcare collaboration for epilepsy management. However, the pharmacy...
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Nebivolol attenuates the anticonvulsant action of carbamazepine and phenobarbital against the maximal electroshock-induced seizures in mice
BackgroundDue to co-occurrence of seizures and cardiovascular disorders, nebivolol, a widely used selective β 1 -blocker with vasodilatory properties,...
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Consider potential drug interactions when starting combination therapy with antiepileptic drugs
Alternative monotherapy and adjunctive therapy are both valid options following failure of initial monotherapy with an antiepileptic drug (AED)....
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Changes in prescribing of psychotropic vs some physical health medication in primary care through the COVID-19 pandemic in England: a national-level survey
IntroductionThe COVID-19 pandemic globally impacted healthcare provision. Prescribing changes in common medications can be used as a marker for new...
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Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations
Among clinically highly efficient antiseizure medications (ASMs) there are modifiers of the presynaptic release machinery. Of them, levetiracetam and...
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Accelerating the Availability of Medications to Pediatric Patients by Optimizing the Use of Extrapolation of Efficacy
Improving pediatric therapeutic development is a mission of universal importance among health authorities, pharmaceutical companies, academic...
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Drug Safety in Pregnancy: Data, Methods, and Challenges
This entry provides an overview of how drug safety research in pregnancy is conducted, the challenges faced when undertaking this type of work, and...
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Preparation of Cinnamon-Coated Cerium Oxide Nanoparticles and Evaluation of their Anticonvulsant Effect in Rats
This study was aimed at evaluating the effects of cinnamon-coated cerium oxide nanoparticles as a new drug for treatring pentylenetetrazole-induced...
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Biological Activity of Condensed Pyridine Derivatives with a Bridgehead Nitrogen Atom
Data on the main types of biological activity of condensed pyridine derivatives with a bridgehead nitrogen atom, including the structures of the most...
