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Evidence of Selective Interaction of Nerve Growth Factor Dipeptide Mimetic GK-2 with TrkA Receptor Using TrkA and TrkB Knockout HT-22 Cells
TrkA and TrkB knockout HT-22 cell lines were used to prove that the neuroprotective properties of GK-2 [ bis ( N -monosuccinyl- L -glutamyl- L -lysine...
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Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies
The desire to find a gold-standard therapy for depression is still ongoing. Develo** one universal and effective pharmacotherapy remains...
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The impact of noradrenergic neurotoxin DSP-4 and noradrenaline transporter knockout (NET-KO) on the activity of liver cytochrome P450 3A (CYP3A) in male and female mice
BackgroundOur earlier studies have shown that the brain noradrenergic system regulates cytochrome P450 (CYP) in rat liver via neuroendocrine...
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Ventricular arrhythmias, antiarrhythmic therapy and thyroidal illness in advanced heart failure: a case report and review of the literature
Ventricular arrhythmias are common and can modify the risk profile in patients with advanced heart failure. Guideline-directed medical therapy as...
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KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain
BackgroundEpilepsy frequently coexists with neuropathic pain. Our approach is based on the search for active compounds with multitarget profiles...
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Antipsychotic drug—aripiprazole against schizophrenia, its therapeutic and metabolic effects associated with gene polymorphisms
Second-generation antipsychotics are widely used for the treatment of schizophrenia. Aripiprazole (ARI) is classified as a third-generation...
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Cyclosporin A Enhance the Cytotoxicity of Immunotoxin to the HER-2-Overexpressing SK-OV-3 Cells: A Prospective Study
This study explores the synergistic effect of T-CUS 245C combined with cyclosporin A, and its possible mechanism. T-CUS 245C is an immunotoxin...
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Cannabinoids and their derivatives in struggle against melanoma
AbstractMelanoma is one of the most aggressive malignances in human. Recently developed therapies improved overall survival rate, however, the...
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Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics
Proton pump inhibitors (PPIs) are the most commonly prescribed drugs for the treatment of non-erosive reflux disease (NERD), ulcers associated with...
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The role of mucosal barriers in human gut health
The intestinal mucosa is continuously exposed to a large number of commensal or pathogenic microbiota and foreign food antigens. The intestinal...
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A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central nervous system (CNS) leading to mental deterioration and...
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Signaling pathways underlying changes in the contractility of the stomach fundus smooth muscle in diabetic rats
Dysfunction of gastrointestinal (GI) motility is a common complication in patients with diabetes mellitus (DM). Studies related to changes in fundus...
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Antidepressant-like effects of kynurenic acid in a modified forced swim test
BackgroundKynurenic acid (KYNA) is an l -tryptophan metabolite with neuromodulatory activities, regulating the release of neurotransmitters such as...
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Recent and updated pharmacotherapy of migraine
Migraine is a complex and still debatable neurovascular disorder that is on the rise globally, affecting patients of all ages. Various drugs are...
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Pharmacogenetic Tests for Antipsychotic-Induced Weight Gain
Second-generation antipsychotic substances, as compared with first-generation antipsychotics, are more effective in relation to psychotic symptoms...
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Significant reduction of vascular reactivity with dantrolene and nimodipine in diabetic rats: a potential approach to cerebral vasospasm management in diabetes
BackgroundDiabetics have a higher risk of develo** cerebral vasospasms (CVSPs) than non-diabetics. Current therapies are ineffective in reducing...
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Lacidipine attenuates caffeine-induced anxiety-like symptoms in mice: Role of calcium-induced oxido-nitrosative stress
BackgroundAnxiety is a disorder of multi-factorial pathogenesis involving interrelated pathways of neurotransmitters, oxidative stress and...
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Effects of central RVD-hemopressin(α) administration on anxiety, feeding behavior and hypothalamic neuromodulators in the rat
BackgroundThe endocannabinoid (eCB) system is strongly involved in the regulation of anxiety and feeding behavior. RVD-hemopressin(α) [RVD-hp(α)], a...
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Angiotensin converting enzyme and neprilysin inhibition alter pain response in dexhamethasone-induced hypertensive rats
BackgroundWe hypothesized that renin-angiotensin system and neprilysin (NEP) inhibition can modulate the nociceptive parameters on hypertensive rats....
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Involvement of hippocampal angiotensin 1 receptors in anxiety-like behaviour of olfactory bulbectomized rats
BackgroundAccumulated evidence suggests that the enhanced brain angiotensin II (Ang II) activity is associated with stress and anxiety.
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