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Biopharmaceutical Evaluation of a Photoprotective Preparation Based on Melanin Isolated from Seed Episperm of Horse Chestnut (Aesculus hippocastanum L.)
The article focused on a study of the release of melanin from its gel dosage form and the toxicological properties of the gel. The recorded release...
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Microextraction Recovery of Tilmicosin Phosphate for HPLC-UV Determination in Washings from Surfaces of Pharmaceutical Equipment
A method for microextraction recovery and concentration of tilmicosin phosphate in washings from surfaces of pharmaceutical equipment for its...
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Development of a Peroral Dosage Form of a Nitrosyl Iron Complex with Thiosulfate Ligands, an Exogenous Nitric Oxide (NO) Donor
The composition and technology for obtaining a solid dosed stable dosage form of a promising representative of the class of nitrogen monoxide (NO)...
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Management of orofacial pain starts with careful differentiation of odontogenic and non-odontogenic pain
The diagnosis and management of orofacial pain can be challenging, especially when pain of non-odontogenic origin mimics dental pain or is localised...
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Investigation of the Effects of Dimethyl Sulfoxide in Experimental Gout with Comparison of Dexamethasone and Indomethacin
Gout arthritis is an inflammatory arthritis characterized by increased serum uric acid and accumulation of monosodium urate (MSU) crystals in soft...
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Targeting Endothelial Progenitor Cells Reparative Potential Via Canonical Wnt/NOX-4 Signaling Pathway in Rats Dyslipidemia: Role of Resveratrol
Signaling pathways guiding the reparative function of endothelial progenitor cells (EPCs) are complex. Conflicts involve the double-face role of...
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Efficacy and Safety of Montelukast Sodium Tablets Combined with Budesonide Suspension in the Treatment of Patients with Bronchial Asthma
To evaluate the efficacy and safety of montelukast sodium tablets combined with budesonide suspension in the treatment of patients with bronchial...
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Development and Validation of a Method for Quantification of Lisinopril, Indapamide, Metoprolol, Valsartan, and Amoldipine in Human Blood Serum by HPLC-MS/MS
A method for quantification of antihypertensive drugs (lisinopril, indapamide, metoprolol, valsartan, and amlodipine) in human blood serum was...
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Comparative Evaluation of Alternative Deblocking Agents to Piperidine for Solid-Phase Synthesis of Peptides
The availability of piperidine, which is widely used for deblocking α-amine groups in solid-phase peptide synthesis using Fmoc methodology, is now...
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Design and Spectral Validation of RAD51 Inhibitors Based on BRC4 (1523-1546)
RAD51 is a core factor for homologous recombination to repair DNA double-strand breaks and overexpressed in breast cancer cells. Truncated peptide...
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Personalise treatment for rosacea by selecting from a range of options for individual features
Rosacea is a chronic, inflammatory condition of facial skin. Treatment of rosacea should be based on its presenting features i.e. inflammatory...
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Implications of inflammatory cell death-PANoptosis in health and disease
Regulated cell death (RCD) pathways, such as pyroptosis, apoptosis, and necroptosis, are essential for maintaining the body’s balance, defending...
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Physicochemical Properties of Two Mexican Stingless Bee Honeys to Strengthen Their Biocultural Value
Honey production in Mexico is an ancient economic, social, and biocultural activity for indigenous communities, Mayas, and Totonacs, among others....
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Mitochondrial targeted antioxidants as potential therapy for huntington’s disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expansion in CAG repeat on huntington (Htt) gene, leading to a...
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Insulin resistance, clinical presentation and resistance to selective serotonin and noradrenaline reuptake inhibitors in major depressive disorder
BackgroundThe understanding of mechanisms underlying non-response to antidepressants is limited. The latest data highlights the role of insulin...
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Medication errors in older patients: a pharmacovigilance perspective
IntroductionDrug regulatory agencies are particularly interested in pharmacovigilance data relating to medication errors (MEs) involving a...
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Take an individualized approach when managing women of reproductive age with uterine fibroids
Uterine fibroids are the most common gynaecological tumour in women of reproductive age and can cause heavy menstrual bleeding, anaemia, pelvic pain,...
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Long-term topical corticosteroid treatment for atopic dermatitis: an in-depth analysis of safety, efficacy, withdrawal, and patient experiences
Atopic dermatitis, often referred to as eczema, is classified as a chronic inflammatory skin disorder with increasing prevalence. Topical...
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Dihydroartemisinin inhibits follicular helper T and B cells: implications for systemic lupus erythematosus treatment
Systemic lupus erythematosus (SLE) is a common autoimmune disease, and its pathogenesis mainly involves the aberrant activation of B cells through...
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Uncovering the unique characteristics of different groups of 5-HT5AR ligands with reference to their interaction with the target protein
BackgroundThe serotonin 5-HT 5A receptor has attracted much more research attention, due to the therapeutic potential of its ligands being...
