Search
Search Results
-
Protein-Ligand-Wechselwirkungen als Grundlage der Arzneistoffwirkung
Für den gezielten Entwurf eines Arzneistoffs gilt es zunächst die Frage zu beantworten: Wie wirkt überhaupt ein Arzneistoff? Wie findet Aspirin® die...
-
Recycling Preparative Liquid Chromatography, the Overlooked Methodology for the Purification of Natural Products
Frequently, preparative high-performance liquid chromatography separations of complex natural product mixtures by adsorption chromatography are...
-
Opportunities and challenges in application of artificial intelligence in pharmacology
Artificial intelligence (AI) is a machine science that can mimic human behaviour like intelligent analysis of data. AI functions with specialized...
-
Effects of [(1-phenyl-5-formyl-1H-imidazol-4-yl)thio]acetic Acid on the Antioxidant Status of the Liver and Kidney in Rats with Tetrachloromethane Poisoning
The effects of [(1-phenyl-5-formyl-1 H -imidazol-4-yl)thio]acetic acid on oxidant-antioxidant homeostasis in rats with tetrachloromethane poisoning...
-
Structural feature of TRAFs, their related human diseases and therapeutic intervention
Several studies have been conducted over the years to unravel the structural information on the receptors that bind to tumor necrosis factor...
-
Emerging small molecule antivirals may fit neatly into COVID-19 treatment
Numerous treatments exist for COVID-19, the illness caused by SARS-CoV-2 virus, although most are not well established; among these are several small...
-
Early Detection of Toxic Cyanobacteria in Bulgarian Dam Water and In Vitro Evaluation of the Effect of Saponins From Astragalus glycyphyllos and A. glycyphylloides, in Cyanotoxin (Anatoxin-α)-Induced Neurotoxicity
As a result of the blooming, certain Cyanobacteria ( i.e ., Microcystis ) produce toxins, at concentrations that could be toxic. In this study, a group...
-
Selected transgenic murine models of human autoimmune liver diseases
Murine models of human diseases are of outmost importance for both studying molecular mechanisms driving their development and testing new treatment...
-
Asenapine transdermal delivery system (Secuado®) in schizophrenia: a profile of its use in the USA
Asenapine, an atypical antipsychotic indicated for the treatment of schizophrenia, was first available as a twice-daily sublingual tablet. However,...
-
Consider clinically relevant pharmacokinetic drug interactions when co-prescribing drugs in attention-deficit/hyperactivity disorder
Polypharmacy is common in the treatment of attention-deficit hyperactivity disorder (ADHD). However, the use of multiple drugs increases the risk of...
-
Potential Role of Herbal- and Bacterial-Derived Peptides Against Colorectal Cancer
Despite recent advances in the prevention, diagnosis, and treatment of colorectal cancer as the third cause of cancer death, the development of...
-
Nutraceuticals Derived from Dietary Spices as Candidate Molecules in Targeting Glioma Signaling Pathways
Spices have been used by people for generations as a source of food flavors to increase culinary delicacy. These ingredients not only give the food...
-
Amyloidogenic, neuroinflammatory and memory dysfunction effects of HIV-1 gp120
Human immunodeficiency virus 1 (HIV-1) infection can cause several HIV-associated neurocognitive disorders a variety of neurological impairments...
-
Rimegepant orally disintegrating tablets in the acute treatment of migraine: a profile of their use
Rimegepant orally disintegrating tablets (ODT) for sublingual or oral use (Nurtec™ ODT) are a valuable option for the acute treatment of...
-
Interaction of the Medicinal Plant Piper rivinoides Ethanolic Extract, Fractions, and Isolated Neolignans with Rat CYP1A Activity
Piper rivinoides Kunth, known in Brazil as “aperta-ruão,” is a medicinal glabrous shrub (3 to 6 m high) that belongs to the Piperaceae family. Some...
-
Peptide Phage Display: Molecular Principles and Biomedical Applications
Phage display (PD) is a technology based on the presentation of functional exogenous peptides on the capsid surface of bacteriophages. PD is...
-
The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
The complex orchestration of gene expression that mediates the transition of epithelial cells into mesenchymal cells is implicated in cancer...
-
Generative Function of Female Rats Upon Intragastric Administration of Tablets of the New Steroid Drug Gestobutanoil
The generative function of female rats upon intragastric administration of tablets of gestobutanoil at doses of 0.25 and 2.5 mg/kg (calculated doses...
-
Copalic Acid: Occurrence, Chemistry, and Biological Activities
(–)-Copalic acid is a naturally occurring labdane‐type diterpene acid usually isolated from oleoresins of Copaifera trees, being considered the...
-
A review of the effects of ticagrelor on adenosine concentration and its clinical significance
BackgroundTicagrelor is an oral antiplatelet drug that can reversibly bind to the platelet P2Y12 receptor. Ticagrelor is metabolized mainly by CYP3A4...
