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Using the Design of Experiments for Development, Validation, and Optimization of HPLC-UV Assay of Tamoxifen Citrate in Polymeric Nanoparticles
A high-performance liquid chromatography method has been developed, optimized and validated as per ICH guidelines for the measurement of tamoxifen...
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Development and Validation of Uv-Spectrophotometric Method for the Determination of Atorvastatin Calcium Using Sodium Citrate as Hydrotropic Agent
Simple, rapid, precise, accurate and specific UV-spectrophotometric method has been developed for atorvastatin calcium determination in bulk and in...
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Investigation of Eurycoma longifolia Extract on Alleviating Steatosis by Using In Vivo and In Vitro Steatotic Models: Mechanisms Through Activation of AMPK and Autophagic Flux
Eurycoma longifolia Jack, Simaroubaceae, is a popular tropical herb native to Southeast Asia, known for its medicinal properties. This study aimed to...
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Validation of TLC-Densitometry Method for Estimation of Catechin in Acacia catechu Heartwood
The present study was primarily aimed to determine catechin in Acacia catechu extract using high performance thin layer chromatography (HPTLC) which...
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Seasonal Chemical Variability of Aloysia polystachya Leaves
The use of natural products as food ingredients requires adequate regulation and safety assessment for its legal commercialization. Aloysia polystachya ...
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Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC
Gefitinib, as the first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has achieved great advances in the...
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Factors affecting the availability of tracer health commodities in public facilities at Tana River County, Kenya
BackgroundDelivery of quality healthcare is significantly based on the level of commitment among health facilities. This includes building a strong...
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Quality Requirements and Analysis
For the control of the production of medicines quality requirements are essential. Quality requirements cover the quality of the preparation...
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Comparison of the Chemical Composition and Antioxidant Activity of Essential Oils from the Leaves and Flowers of Sambucus nigra
Essential oils of Sambucus nigra were obtained by hydrodistillation and analyzed using the GC-MS technique, which led to the identification and...
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A Novel Artemisinin-Derived Sesquiterpene from Bacopa gratioloides Volatile Oil by Sustainable and Enhanced Procedures
Bacopa gratioloides (Cham.) Chodat & Hassl., Plantaginaceae, is an aquatic species underexplored and found in the hostile biome Chaco, Brazil. In...
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Anacardic Acid Mixture: Utilization of a Byproduct for the Sustainable Development of a Potential Antichagasic Agent Against Trypanosoma cruzi
The work presents an optimization of the extraction and purification processes of the anacardic acids mixture and its evaluation as a potential...
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Anti-inflammatory Activity of Total Alkaloids in Nelumbo nucifera and Simultaneous Determination of Major Bisbenzylisoquinolines
Plumula nelumbinis , the green embryo of the mature seeds of Nelumbo nucifera Gaertn., Nelumbonaceae, is widely used in traditional Chinese medicine...
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Bioprospecting Prenyl Flavanones from Dalea boliviana: Structural Insights and Antifungal Properties Against Azole-Resistant Candida albicans
Prenyl flavonoids are natural compounds with a relatively narrow distribution in plants with particular structural and pharmacological properties. A...
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Study of Impurity Profiles in Raw Materials and Tablets of Rutin and Its Production Process: Correlation Analysis
An HPLC-UV method with high sensitivity and good resolution, calculated by the principal component external standard method with correction factors...
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Simultaneous Determination of Buddleoside, Rosmarinic Acid and Chlorogenic Acid by LC–MS/MS for Quality Control of Yinpujiedu Commercial Products
A simple LC–MS/MS method has been developed and validated for the simultaneous quantitative analysis of buddleoside, rosmarinic acid and chlorogenic...
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Development and Validation of an UPLC Method for Quality Control of Plantago major
Plantago major L. and Plantago australis Lam., Plantaginaceae, have been used in folk medicine mainly as anti-inflammatory and healing agents. The...
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Simultaneous Estimation of Acetaminophen, Chlorpheniramine Maleate, Methyl Paraben, Propyl Paraben, Sodium Benzoate and Related Impurities in Over-the-Counter Syrup Formulation
Acetaminophen, chlorpheniramine maleate syrup is an over-the-counter (OTC) non-compendial syrup dosage form. Compendial monograph methods are not...
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Spectrophotometric Methods for Simultaneous Determination of Sulfadoxine and Pyrimethamine in Bulk and Tablet Forms
Three sensitive and accurate spectrophotometric methods were developed for the quantitative determination of sulfadoxine (SUL) and pyrimethamine...
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Trehalose ameliorates prodromal non-motor deficits and aberrant protein accumulation in a rotenone-induced mouse model of Parkinson’s disease
Trehalose has been recently revealed as an attractive candidate to prevent and modify Parkinson’s disease (PD) progression by regulating autophagy;...
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Vitamin K: a Potential Neuroprotective Agent
Neurodegeneration, a progressive disease due to the arrested development of atrophy and regression of neuron function, is the most common disorder...
