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E1231 Alleviates Diabetic Cardiomyopathy by Regulating the Silent Information Regulator 1/Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α/Nuclear Factor Erythroid 2-Related Factor 2 Pathway
We aimed to investigate the underlying function and mechanism of E1231 against diabetic cardiomyopathy (DCM). H9c2 cells were exposed to either 33...
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Take an individualized and multipronged approach when managing older adults with type 2 diabetes
The prevalence of diabetes in older adults is increasing worldwide and its management is complicated by the comorbidity, cognitive and psychosocial...
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Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by a burning sensation and eczematous lesions...
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What is the role of pioglitazone for patients with type 2 diabetes in value-based care settings?
Type 2 diabetes is a significant burden on the healthcare system with unique challenges in the value-based payment system. Although there are a...
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Current Prospects and Clinical Status of Microalgae Derived Chemotherapeutics
Globally, despite clinical advancements made over a decade, cancer remains a prominent cause of death. Numerous drugs have been chemically...
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Rimegepant orally disintegrating tablets in the acute treatment of migraine: a profile of their use
Rimegepant orally disintegrating tablets (ODT) for sublingual or oral use (Nurtec™ ODT) are a valuable option for the acute treatment of...
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Using Liposomal and Intranasal Drugs and Pioglitazone for the Treatment and Prevention of Alzheimer’s Disease (Review)
This review article provides information on the development of liposomal drug delivery systems to cross the blood(brain barrier (BBB). Information on...
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Characterization of the Active Components of Aurantii fructus Causing Dry Mouth by Analysis of Aquaporin 5 Expression
Aurantii fructus , the dried immature fruit of Citrus aurantium L., Rutaceae, or its cultivated variants, has been used in traditional Chinese...
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Potential biological functions and future perspectives of sialylated milk oligosaccharides
Sialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides (BMOs). First, the safety...
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Anti-amnesic and Neuroprotective Potential of Genistein Against Alzheimer’s Disease
Alzheimer’s disease, the most prevalent neurodegenerative disorder, is characterized by language deficits, impairment of problem-solving ability,...
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Stimuli-Responsive Non-viral Nanoparticles for Gene Delivery
Considering nucleic acids as the language of life and the genome as the instruction manual of cells, their targeted modulation promises great...
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Catha edulis and Cathinone Effect on Bone Parameters and Adipokines Gene Expression in Obese Male Mice
This study aims to determine the effects of Catha edulis (Vahl) Forssk. ex Endl., Celastraceae, and its bioactive alkaloid, cathinone, on liver...
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Unraveling snake venom phospholipase A2: an overview of its structure, pharmacology, and inhibitors
Snake bite is a neglected disease that affects millions of people worldwide. WHO reported approximately 5 million people are bitten by various...
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The study of platelet aggregation using a microtiter plate reader ‒ methodological considerations
Optical aggregometry by 96-well plate assay, the microplate method, is a fast, efficient, and readily available method for measuring the...
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Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions
The emergence of antibody-drug conjugates (ADCs) as a potential therapeutic avenue in cancer treatment has garnered significant attention. By...
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Aspartylprotease-Inhibitoren
Auch die Aspartylproteasen spalten Peptidbindungen, allerdings verwenden sie einen anderen Mechanismus. Sie verdanken ihren Namen dem Vorliegen...
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Enzymatic Stability and Possible Molecular Targets of Synthetic Peptide HFRWPGP
Molecular aspects of the biological mechanism of action of the synthetic peptide HFRWPGP, including an assessment of the stability to membrane...
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Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism
Metabolic disturbances in the brain are assumed to be early changes involved in the pathogenesis of depression, and these alterations may be...
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Duration and Dose–Response Relationship of the Analgesic Action of the Tetrapeptide H-Tyr-D-Arg-Phe-Gly-NH2 (Taphalgin), a Synthetic Derivative of Dermorphine, in Comparison with Morphine Hydrochloride
The effect of the tetrapeptide H-Tyr- D -Arg-Phe-Gly-NH 2 (Taphalgin), a synthetic derivative of dermorphine, was evaluated in the tail-flick test in...
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Synthesis and Structure—Activity (Anxiolytic) Relationship Analysis of Leucyltryptophan Ligands of 18-KDA Translocator Protein
Previously, researchers at Zakusov State Institute of Pharmacology used an original strategy for designing pharmacologically active dipeptides based...
