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In Vitro Evaluation of Anti-Angiogenic Efficacy, Cell Migration Activity and Cell Survival Effect Against Hydrogen Peroxide-Induced Damage of Prunetin
Anti-angiogenic isoflavonoids are gaining attention as a novel approach in the prevention and treatment of tumor progression and metastasis. These...
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A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice
BackgroundIA-0130 is a derivative of 3-(1,3-diarylallylidene)oxindoles, which is a selective estrogen receptor modulator (SERM). A previous study...
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Inhibitors of Nitric Oxide Production from the Seeds of Myristica fragrans: Experimental and Computational Results
This study focuses on the extraction of eleven compounds from Myristica fragrans Houtt., Miristicaceae, seeds, guided by their anti-inflammatory...
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Role of Natural Flavonoid Products in Managing Osteoarthritis
Flavonoids belong to a subgroup of polyphenol bioactive compounds of plant origin. They are a topic of interest for their anti-inflammatory and...
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Protective Effect of Schisandra chinensis Extract Against Ethanol-Induced Gastric Ulcers in Mice by Promoting Anti-inflammatory and Mucosal Defense Mechanisms
Schisandra chinensis (Turcz.) Baill., Schisandraceae, is a common Chinese traditional medicine for the treatment of nervous system disorders and...
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Natural Populations of Galphimia spp. Attenuates In Vitro and In Vivo Inflammatory Responses
The genus Galphimia , Malpighiaceae, is widely distributed in Mexico and represented by 22 species including medicinal species. The sedative and...
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Investigation of the Antinociceptive and Gastroprotective Potential of the Flavonoid Tricin and its Possible Mechanism of Action
Tricin is a flavonoid that occurs in monocotyledonous plants and exhibits a broad pharmacological spectrum, including anti-inflammatory and...
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Reno-protective effect of protocatechuic acid is independent of sex-related differences in murine model of UUO-induced kidney injury
BackgroundObstructive nephropathy is a condition often caused by urinary tract obstruction either anatomical (e.g., tumors), mechanical (e.g.,...
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Chemical Compositions and Pharmacological Activities of Iberis amara L. (A Review)
Iberis amara L. belongs to the family of Brassicaceae, which is native to Southern Europe. It is a bloomer cultivated as an ornamental and medicinal...
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Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Astragali Radix ( A. Radix ) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge.,...
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In Vivo Study to Explore the Antiarthritic Potential of Tiliroside on Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats
The purpose of this research was to examine the pharmacological properties and potential mechanism of action of tiliroside in rheumatoid arthritis....
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Various Formulations of Glycyrrhizic Acid and the Possibility of Their Use in Virus-Associated and Inflammatory Diseases
Pharmaceuticals containing glycyrrhizic acid that exhibit a pleiotropic effect and reduce the risk of progression of cervical lesions associated with...
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The Anti-inflammatory and Immune-Boosting Potential of Quercetin-3-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside in LPS–Stimulated RAW264.7 Macrophages
Diospyros kaki L.f., Ebenaceae, have been used since centuries in traditional medicines in many Asian countries as it contains numerous flavonoids....
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Investigation of the Effects of Dimethyl Sulfoxide in Experimental Gout with Comparison of Dexamethasone and Indomethacin
Gout arthritis is an inflammatory arthritis characterized by increased serum uric acid and accumulation of monosodium urate (MSU) crystals in soft...
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Melatonin and oral diseases: possible therapeutic roles based on cellular mechanisms
Oral diseases, including periodontal disorders, oral cancer, periodontitis, and mucositis are the major challenges for both patients and healthcare...
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In Vitro Study of the Cytotoxic and Immunotropic Effects of Molnupiravir and Favipiravir
The effects of the antiviral drugs molnupiravir and favipiravir on the viability of human embryonic lung cells and the production of cytokines by...
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New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study
BackgroundChronic inflammation in the course of inflammatory bowel disease may result in colon cancer, or colitis-associated colorectal cancer...
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Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
Fibrosis, the excessive deposition of fibrous connective tissue in an organ in response to injury, is a pathological condition affecting many...
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The protective effects of statins in traumatic brain injury
Traumatic brain injury (TBI), often referred to as the “silent epidemic”, is the most common cause of mortality and morbidity worldwide among all...
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Telmisartan alone or in combination with etanercept improves anemia associated with rheumatoid arthritis in rats: a possible role of anti-inflammatory and reno-protective effects
BackgroundThere are conflicting data regarding angiotensin receptor blockers (ARBs) induced anemia and its beneficial anti-inflammatory effect in...
