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Enhancement of S(+)-zaltoprofen oral bioavailability using nanostructured lipid carrier system
Zaltoprofen is a nonsteroidal anti-inflammatory drug with poor oral bioavailability. S(+)-zaltoprofen (SZPF)-loaded nanostructured lipid carriers...
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Assay of Antioxidant Activity and Bioactive Compounds of Cornelian Cherry (Cornus mas L.) Fruit Extracts Obtained by Green Extraction Methods: Ultrasound-Assisted, Supercritical Fluid, and Subcritical Water Extraction
Bioactive compounds of cornelian cherry ( Cornus mas L.) fruits were extracted by green extraction methods including ultrasound-assisted (with three...
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Synthesis of Natural Product Derivatives as Larvicides Against Aedes aegypti
Larvicides are pesticides that kill insects during their early life stages. Aedes aegypti (Linnaeus, 1762), Diptera: Culicidae, usually breed in...
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Polypogon monspeliensis Hepatoprotective Attributes: UHPLC/QTOF-MS/MS Metabolite Profiling and In Vitro and In Silico Studies
Polypogon monspeliensis (L.) Desf. is an annual monocot weed belonging to Poaceae family, with reported folkloric medicinal uses. In this work, the...
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Spectrophotmetric Determination of Dissociation Constanst of Isoniazid and Its Sulfonyl Derivatives
Among the physicochemical properties of drugs, dissociation constant (p K a) is the most important parameter for the design and development of new and...
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Technology Transfer Process
Technology transfer (TT) is a crucial step in the pharmaceutical industry to ensure that the documented knowledge, experience, and proven ability of...
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Nanoemulsion Improves the Anti-inflammatory Activity of Carvacrol upon Oral Administration
Carvacrol is the main phenolic monoterpene isolated from the essential oils of plants from the genus Origanum L., Lamiaceae. Carvacrol has several...
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Experimental Evaluation of Chronic Toxicity of Amphamide – a New Semisynthetic Derivative of Amphotericin B
Amphotericin B (AmB) remains a drug of first choice for treatment of most severe mycoses despite significant toxicity and solubility problems....
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Bioavailability and Safety of Dihydroquercetin (Review)
Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used...
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Physicochemical Properties of a Phenyltetrahydroquinolinedione Derivative with TRPA1 Antagonist Activity
A new active pharmaceutical ingredient (API) with TRPA1-antagonist activity (phenyltetrahydroquinolinedione derivative) was a white or almost white...
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Development of a Spectrophotometric Method for the Measurement of Kinetic Solubility: Economical Approach to be Used in Pharmaceutical Companies
To decrease the consumption of expensive active pharmaceutical ingredients (APIs) during the determination of their solubility limits by traditional...
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Comparative Dose- and Time-Dependent Manner of Resveratrol on Human Epithelial Cell Types
Resveratrol is a conventional nutraceutical compound that has been extensively studied for therapeutic applications, especially cancer therapy;...
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Anti-amnesic and Neuroprotective Potential of Genistein Against Alzheimer’s Disease
Alzheimer’s disease, the most prevalent neurodegenerative disorder, is characterized by language deficits, impairment of problem-solving ability,...
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The Financial Benefits of Faster Development Times: Integrated Formulation Development, Real-Time Manufacturing, and Clinical Testing
PurposeFaster drug development times get new therapies to patients sooner and financially benefit drug developers by shortening the time between...
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Recent Advances in the Pharmacological Properties and Molecular Mechanisms of Carvacrol
Plant secondary metabolites have received a lot of attention for their immense pharmacological activities and low side effects. Monoterpenes,...
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Biopharmaceutical Evaluation of a Photoprotective Preparation Based on Melanin Isolated from Seed Episperm of Horse Chestnut (Aesculus hippocastanum L.)
The article focused on a study of the release of melanin from its gel dosage form and the toxicological properties of the gel. The recorded release...
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Synthesis and Evaluation of New 5,15-Diarylporphyrin Derivatives for Photodynamic Therapy
Two new 5,15-diarylporphyrin derivatives ( L1 and L2 ) were designed and synthesized and their anti-esophageal cancer effects as photosensitizers were...
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Mononuclear Metal Complexes of Moxifloxacin with Antacids: Synthesis, Spectroscopic Characterization, and Antimicrobial Activities
Mononuclear metal complexes of 1-cyclopropyl-7-[( S , S )-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinoline carboxylic...
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Synthesis and Anti-Inflammatory Activity Evaluation of Some Benzimidazole Derivatives
Hyper-inflammation aggravates the symptoms of both communicable and non-communicable diseases. Therefore, anti-inflammatory compounds may have wide...
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Morita Baylis Hillman Adduct Serves as Ligand in the Synthesis of Transition Metal Complexes Exhibiting Antibacterial Activity
In the present work, Morita—Baylis–Hillman (MBH) adduct ligand 3 was prepared under MBH reaction conditions. The compound was purified by...
